期刊
JOURNAL OF CELL SCIENCE
卷 134, 期 12, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.247163
关键词
IFT; Cilia; Dynein; Kinesin; Protein structure; Transport
类别
资金
- Max Planck Society (Max-Planck-Gesellschaft)
- Human Technopole
- European Research Council (ERC) under the European Union [819826]
- European Research Council (ERC) [819826] Funding Source: European Research Council (ERC)
The intraflagellar transport (IFT) system is a crucial molecular machine used by cells to assemble and maintain the cilium, shuttling structural components and signaling receptors within the organelle. IFT trains, composed of IFT-A and IFT-B adaptor protein complexes, are powered by kinesin-2 and IFT-dynein motors for bidirectional movement along microtubules.
The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to assemble and maintain the cilium, a long organelle extending from eukaryotic cells that gives rise to motility, sensing and signaling. IFT plays a critical role in building the cilium by shuttling structural components and signaling receptors between the ciliary base and tip. To provide effective transport, IFT-A and IFT-B adaptor protein complexes assemble into highly repetitive polymers, called IFT trains, that are powered by the motors kinesin-2 and IFT-dynein to move bidirectionally along the microtubules. This dynamic system must be precisely regulated to shuttle different cargo proteins between the ciliary tip and base. In this Cell Science at a Glance article and the accompanying poster, we discuss the current structural and mechanistic understanding of IFT trains and how they function as macromolecular machines to assemble the structure of the cilium.
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