Circadian clock, carcinogenesis, chronochemotherapy connections

CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

(2021) Marrit Putker et al.   EMBO JOURNAL

Clocks, cancer, and chronochemotherapy

(2021) Aziz Sancar et al.   SCIENCE

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

(2021) Ayesha A. Shafi et al.   Nature Communications

Circadian Rhythms and the Transcriptional Feedback Loop (Nobel Lecture)**

(2021) Michael Rosbash   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cancer clocks in tumourigenesis: the p53 pathway and beyond

(2021) Ewan Michael Stephenson et al.   ENDOCRINE-RELATED CANCER

The phosphorylation switch that regulates ticking of the circadian clock

(2021) Rajesh Narasimamurthy et al.   MOLECULAR CELL

Circadian rhythm as a therapeutic target

(2021) Wei Ruan et al.   NATURE REVIEWS DRUG DISCOVERY

Circadian Mechanisms in Medicine

(2021) Ravi Allada et al.   NEW ENGLAND JOURNAL OF MEDICINE

Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle

(2021) Yool Lee et al.   Science Advances

The Impact of the Circadian Clock on Skin Physiology and Cancer Development

(2021) Janet Lubov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

(2020) Jonathan M Philpott et al.   eLife

Genome-wide single-nucleotide resolution of oxaliplatin–DNA adduct repair in drug-sensitive and -resistant colorectal cancer cell lines

(2020) Courtney M. Vaughn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Links between the Circadian Clock and the Cell Cycle

(2020) Elham Farshadi et al.   JOURNAL OF MOLECULAR BIOLOGY

Coupled network of the circadian clocks: a driving force of rhythmic physiology

(2020) Anna‐Marie Finger et al.   FEBS LETTERS

Association Between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis

(2020) Aishe Dun et al.   Frontiers in Oncology

Circadian regulation of c-MYC in mice

(2020) Zhenxing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation

(2020) Min Jia et al.   ONCOLOGY REPORTS

Molecular mechanism of the repressive phase of the mammalian circadian clock

(2020) Xuemei Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

(2019) Askar Yimit et al.   Nature Communications

Cryptochrome deletion in p53 mutant mice enhances apoptotic and anti-tumorigenic responses to UV damage at the transcriptome level

(2019) Ayse Derya Cavga et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

(2019) Yool Lee et al.   PLOS BIOLOGY

Long-term, genome-wide kinetic analysis of the effect of the circadian clock and transcription on the repair of cisplatin-DNA adducts in the mouse liver

(2019) Yanyan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Medicine in the Fourth Dimension

(2019) Christopher R. Cederroth et al.   Cell Metabolism

Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism

(2019) Kimberly H. Cox et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Molecular mechanisms and physiological importance of circadian rhythms

(2019) Alina Patke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies

(2018) Simone Mocellin et al.   BMC Medicine

Proliferative Glioblastoma Cancer Cells Exhibit Persisting Temporal Control of Metabolism and Display Differential Temporal Drug Susceptibility in Chemotherapy

(2018) Paula M. Wagner et al.   MOLECULAR NEUROBIOLOGY

Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues

(2018) Yanyan Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models

(2018) Panshak P. Dakup et al.   Oncotarget

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

(2018) Youqiong Ye et al.   Cell Systems

Medicine’s secret ingredient — it’s in the timing

(2018) Lynne Peeples   NATURE

Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1

(2018) Tuba Korkmaz et al.   Scientific Reports

Genome-wide mapping of nucleotide excision repair with XR-seq

(2018) Jinchuan Hu et al.   Nature Protocols

Molecular mechanisms and genomic maps of DNA excision repair inEscherichia coliand humans

(2017) Jinchuan Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma

(2017) Emily A. Slat et al.   JOURNAL OF BIOLOGICAL RHYTHMS

RE: Night Shift Work and Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies

(2017) Richard G. Stevens   JNCI-Journal of the National Cancer Institute

Systems Chronotherapeutics

(2017) Annabelle Ballesta et al.   PHARMACOLOGICAL REVIEWS

Circadian Posttranscriptional Regulatory Mechanisms in Mammals

(2017) Carla B. Green   Cold Spring Harbor Perspectives in Biology

Correspondence: Reply to ‘Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα’

(2017) Anton Shostak et al.   Nature Communications

RE: Night Shift Work and Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies

(2017) Richard G. Stevens   JNCI-Journal of the National Cancer Institute

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)

(2016) Aziz Sancar   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

Night Shift Work and Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies

(2016) Ruth C. Travis et al.   JNCI-Journal of the National Cancer Institute

CRY2 and FBXL3 Cooperatively Degrade c-MYC

(2016) Anne-Laure Huber et al.   MOLECULAR CELL

Mammalian Period represses and de-represses transcription by displacing CLOCK–BMAL1 from promoters in a Cryptochrome-dependent manner

(2016) Yi-Ying Chiou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution

(2016) Jinchuan Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy

(2016) Robert Dallmann et al.   TRENDS IN MOLECULAR MEDICINE

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

(2016) Anton Shostak et al.   Nature Communications

Night Shift Work and Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies

(2016) Ruth C. Travis et al.   JNCI-Journal of the National Cancer Institute

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes

(2016) Elizabeth A. Yu et al.   Aging-US

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice

(2015) Kirsten C.G. Van Dycke et al.   CURRENT BIOLOGY

Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution

(2015) Jinchuan Hu et al.   GENES & DEVELOPMENT

Circadian Clock, Cancer, and Chemotherapy

(2014) Aziz Sancar et al.   BIOCHEMISTRY

Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice

(2014) Maria Comas et al.   CHRONOBIOLOGY INTERNATIONAL

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

(2014) Rui Ye et al.   GENES & DEVELOPMENT

Role of p53 in the entrainment of mammalian circadian behavior rhythms

(2014) Toshiyuki Hamada et al.   GENES TO CELLS

Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1

(2014) T.-H. Kang et al.   NUCLEIC ACIDS RESEARCH

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras-Mediated Deregulation of the Circadian Clock in Cancer

(2014) Angela Relógio et al.   PLoS Genetics

Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis

(2013) Marina P Antoch et al.   CELL CYCLE

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

p53 regulates Period2 expression and the circadian clock

(2013) Takao Miki et al.   Nature Communications

Sex moderates circadian chemotherapy effects on survival of patients with metastatic colorectal cancer: a meta-analysis

(2012) S. Giacchetti et al.   ANNALS OF ONCOLOGY

DNA Damage-Specific Control of Cell Death by Cryptochrome in p53-Mutant Ras-Transformed Cells

(2012) J. H. Lee et al.   CANCER RESEARCH

Epigenetic Silencing of the Circadian Clock Gene CRY1 is Associated with an Indolent Clinical Course in Chronic Lymphocytic Leukemia

(2012) Maher Hanoun et al.   PLoS One

Circadian regulation of DNA excision repair: Implications for chrono-chemotherapy

(2011) Tae-Hong Kang et al.   CELL CYCLE

Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock

(2011) Rui Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of skin cancer by the circadian rhythm

(2011) S. Gaddameedhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

(2010) T.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irremediable Complexity?

(2010) M. W. Gray et al.   SCIENCE

THE CIRCADIAN CLOCK GENEPER1SUPPRESSES CANCER CELL PROLIFERATION AND TUMOR GROWTH AT SPECIFIC TIMES OF DAY

(2009) Xiaoming Yang et al.   CHRONOBIOLOGY INTERNATIONAL

Casein Kinase 1 Delta Regulates the Pace of the Mammalian Circadian Clock

(2009) J.-P. Etchegaray et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of cryptochrome reduces cancer risk inp53mutant mice

(2009) Nuri Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian oscillation of nucleotide excision repair in mammalian brain

(2009) Tae-Hong Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY