Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle

Combination therapies with HSP90 inhibitors against colorectal cancer

(2019) Kushtrim Kryeziu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

(2019) Yool Lee et al.   PLOS BIOLOGY

Recent Advances in the Discovery of Novel HSP90 Inhibitors: An Update from 2014

(2019) Yan Xiao et al.   CURRENT DRUG TARGETS

Robust synchronization of the cell cycle and the circadian clock through bidirectional coupling

(2019) Jie Yan et al.   Journal of the Royal Society Interface

The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways

(2019) Chloé C. Nobis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dosing time matters

(2019) Marc D. Ruben et al.   SCIENCE

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

(2019) Zhen Dong et al.   Cancer Discovery

Periodic Oxaliplatin Administration in Synergy with PER2‐Mediated PCNA Transcription Repression Promotes Chronochemotherapeutic Efficacy of OSCC

(2019) Qingming Tang et al.   Advanced Science

Inhibitors of HSP90 in melanoma

(2019) Aleksandra Mielczarek-Lewandowska et al.   APOPTOSIS

Sleep-wake cycles drive daily dynamics of synaptic phosphorylation

(2019) Franziska Brüning et al.   SCIENCE

Circadian control of lung inflammation in influenza infection

(2019) Shaon Sengupta et al.   Nature Communications

Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art

(2018) Hassan Mellatyar et al.   BIOMEDICINE & PHARMACOTHERAPY

Dosing time dependent in vitro pharmacodynamics of Everolimus despite a defective circadian clock

(2018) Yuan Zhang et al.   CELL CYCLE

Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver

(2018) Jingkui Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Cogs: Interplay between Circadian Clock and Cell Cycle

(2018) Jonathan Gaucher et al.   TRENDS IN CELL BIOLOGY

The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models

(2018) Panshak P. Dakup et al.   Oncotarget

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

(2018) Youqiong Ye et al.   Cell Systems

The Clock Protein Bmal1 Regulates Circadian Expression and Activity of Sulfotransferase 1a1 in Mice

(2018) Lianxia Guo et al.   DRUG METABOLISM AND DISPOSITION

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

(2018) Gabriele Sulli et al.   NATURE

A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

(2018) Marc D. Ruben et al.   Science Translational Medicine

The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1

(2018) Elham Farshadi et al.   CELL CYCLE

Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

(2018) Baharan Fekry et al.   Nature Communications

Novel approaches for identification of anti-tumor drugs and new bioactive compounds

(2017) Manabu Kawada et al.   JOURNAL OF ANTIBIOTICS

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systems Chronotherapeutics

(2017) Annabelle Ballesta et al.   PHARMACOLOGICAL REVIEWS

HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes

(2017) Rina M. Mbofung et al.   Nature Communications

Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90

(2017) Feng Hong et al.   PLoS One

The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway

(2016) Weiliang Jiang et al.   CANCER LETTERS

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

Identification of circadian-related gene expression profiles in entrained breast cancer cell lines

(2016) Miguel A. Gutiérrez-Monreal et al.   CHRONOBIOLOGY INTERNATIONAL

Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied

(2016) Julia M. Selfridge et al.   DRUGS

The circadian coordination of cell biology

(2016) Amandine Chaix et al.   JOURNAL OF CELL BIOLOGY

A quantitative FastFUCCI assay defines cell cycle dynamics at a single-cell level

(2016) Siang-Boon Koh et al.   JOURNAL OF CELL SCIENCE

Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

(2016) Toru Matsu-ura et al.   MOLECULAR CELL

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Circadian Metabolism: From Mechanisms to Metabolomics and Medicine

(2016) Steven A. Brown   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy

(2016) Robert Dallmann et al.   TRENDS IN MOLECULAR MEDICINE

Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells

(2015) Yongjun Wang et al.   BIOCHEMICAL PHARMACOLOGY

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Coupling between the Circadian Clock and Cell Cycle Oscillators: Implication for Healthy Cells and Malignant Growth

(2015) Celine Feillet et al.   Frontiers in Neurology

HSP90 Affects the Stability of BMAL1 and Circadian Gene Expression

(2014) Rebecca Schneider et al.   JOURNAL OF BIOLOGICAL RHYTHMS

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Machine Learning Helps Identify CHRONO as a Circadian Clock Component

(2014) Ron C. Anafi et al.   PLOS BIOLOGY

Ras-Mediated Deregulation of the Circadian Clock in Cancer

(2014) Angela Relógio et al.   PLoS Genetics

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes

(2013) S U Lauvrak et al.   BRITISH JOURNAL OF CANCER

Combination Therapy with HSP90 Inhibitor 17-DMAG Reconditions the Tumor Microenvironment to Improve Recruitment of Therapeutic T cells

(2012) A. Rao et al.   CANCER RESEARCH

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

CircaDB: a database of mammalian circadian gene expression profiles

(2012) Angel Pizarro et al.   NUCLEIC ACIDS RESEARCH

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

(2012) Chidambaram Ramanathan et al.   Jove-Journal of Visualized Experiments

Synchronization of Circadian Per2 Rhythms and HSF1-BMAL1:CLOCK Interaction in Mouse Fibroblasts after Short-Term Heat Shock Pulse

(2011) Teruya Tamaru et al.   PLoS One

An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

(2011) Pablo C. Echeverría et al.   PLoS One

17-DMAG targets the nuclear factor- B family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

(2010) E. Hertlein et al.   BLOOD

Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock

(2010) Y. Lee et al.   JOURNAL OF CELL SCIENCE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE