Role of host factors in SARS-CoV-2 entry

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

(2021) Shuai Wang et al.   CELL RESEARCH

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

(2021) Bryan A. Johnson et al.   NATURE

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

(2021) Michihito Sasaki et al.   PLoS Pathogens

Binding of the SARS-CoV-2 Spike Protein to Glycans

(2021) Wei Hao et al.   Science Bulletin

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

(2021) Michel Thépaut et al.   PLoS Pathogens

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

(2020) Wanbo Tai et al.   Cellular & Molecular Immunology

Forty years with coronaviruses

(2020) Susan R. Weiss   JOURNAL OF EXPERIMENTAL MEDICINE

DC/L‐SIGNs of Hope in the COVID‐19 Pandemic

(2020) Adam Brufsky et al.   JOURNAL OF MEDICAL VIROLOGY

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Retinal outcomes of COVID-19: Possible role of CD147 and cytokine storm in infected patients with diabetes mellitus

(2020) Ícaro Raony et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

(2020) Natacha S. Ogando et al.   JOURNAL OF GENERAL VIROLOGY

Identification of common deletions in the spike protein of SARS-CoV-2

(2020) Zhe Liu et al.   JOURNAL OF VIROLOGY

LY6E Restricts the Entry of Human Coronaviruses, Including the Currently Pandemic SARS-CoV-2

(2020) Xuesen Zhao et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

(2020) Antoni G. Wrobel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

(2020) Andrew D. Davidson et al.   Genome Medicine

LY6E impairs coronavirus fusion and confers immune control of viral disease

(2020) Stephanie Pfaender et al.   Nature Microbiology

Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro

(2020) Paul S. Kwon et al.   Cell Discovery

Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions

(2020) So Young Kim et al.   ANTIVIRAL RESEARCH

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

(2020) Tongqing Zhou et al.   Cell Host & Microbe

Biomechanical characterization of TIM protein–mediated Ebola virus–host cell adhesion

(2019) Matthew A. Dragovich et al.   Scientific Reports

IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral Infections

(2019) Xuesen Zhao et al.   Frontiers in Microbiology

TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins

(2019) Minghua Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

(2019) Ruben J. G. Hulswit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4-Dependent Modulation of HIV-1 Entry by LY6E

(2019) Jingyou Yu et al.   JOURNAL OF VIROLOGY

Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors

(2019) Artur Szczepanski et al.   Viruses-Basel

Severe acute respiratory syndrome coronavirus spike protein counteracts BST2‐mediated restriction of virus‐like particle release

(2019) Shiu‐Mei Wang et al.   JOURNAL OF MEDICAL VIROLOGY

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?

(2019) Cagno et al.   Viruses-Basel

TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis

(2019) Bethany Brunton et al.   PLoS Neglected Tropical Diseases

Multifaceted Roles of TIM-Family Proteins in Virus–Host Interactions

(2019) John P. Evans et al.   TRENDS IN MICROBIOLOGY

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors

(2019) Young-Jun Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

(2018) Kazuya Shirato et al.   VIROLOGY

CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells

(2018) Adam L. Vanarsdall et al.   mBio

LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step

(2018) Katrina B. Mar et al.   Nature Communications

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

(2018) Hannah Kleine-Weber et al.   Scientific Reports

Interferon-inducible LY6E Protein Promotes HIV-1 Infection

(2017) Jingyou Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B

(2017) Yoshikazu Tanaka et al.   JOURNAL OF GENERAL VIROLOGY

Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses

(2017) Xuesen Zhao et al.   JOURNAL OF VIROLOGY

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein

(2017) Wentao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

(2017) Yuan Yuan et al.   Nature Communications

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding

(2016) Miao Gui et al.   CELL RESEARCH

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

(2016) Jung-Eun Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular arms race between host innate antiviral response and emerging human coronaviruses

(2016) Lok-Yin Roy Wong et al.   VIROLOGICA SINICA

SnapShot: Antiviral Restriction Factors

(2015) Silvia F. Kluge et al.   CELL

Human Coronavirus HKU1 Spike Protein UsesO-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

(2015) Xingchuan Huang et al.   JOURNAL OF VIROLOGY

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication

(2015) Albrecht von Brunn et al.   Current Opinion in Virology

Overlapping and Distinct Molecular Determinants Dictating the Antiviral Activities of TRIM56 against Flaviviruses and Coronavirus

(2014) B. Liu et al.   JOURNAL OF VIROLOGY

Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells

(2014) A. Milewska et al.   JOURNAL OF VIROLOGY

Characterizing Functional Domains for TIM-Mediated Enveloped Virus Entry

(2014) S. Moller-Tank et al.   JOURNAL OF VIROLOGY

Role of Phosphatidylserine Receptors in Enveloped Virus Infection

(2014) K. Morizono et al.   JOURNAL OF VIROLOGY

TIM-family proteins inhibit HIV-1 release

(2014) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon induction of IFITM proteins promotes infection by human coronavirus OC43

(2014) X. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylserine receptors: Enhancers of enveloped virus entry and infection

(2014) Sven Moller-Tank et al.   VIROLOGY

Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir

(2014) Javier Carbajo-Lozoya et al.   VIRUS RESEARCH

IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms

(2014) Florian Wrensch et al.   Viruses-Basel

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-  treatment

(2013) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

(2013) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

(2013) S. Bertram et al.   JOURNAL OF VIROLOGY

Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry

(2013) S. Moller-Tank et al.   JOURNAL OF VIROLOGY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia Formation

(2013) Zhaohui Qian et al.   PLoS One

IFITM Proteins Restrict Viral Membrane Hemifusion

(2013) Kun Li et al.   PLoS Pathogens

TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine

(2013) Stephanie Jemielity et al.   PLoS Pathogens

Rules of Engagement: Molecular Insights from Host-Virus Arms Races

(2012) Matthew D. Daugherty et al.   Annual Review of Genetics

Viruses and sialic acids: rules of engagement

(2011) Ursula Neu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cyclosporin A inhibits the replication of diverse coronaviruses

(2011) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

CD147/EMMPRIN Acts as a Functional Entry Receptor for Measles Virus on Epithelial Cells

(2010) A. Watanabe et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH

Identification of Major Histocompatibility Complex Class I C Molecule as an Attachment Factor That Facilitates Coronavirus HKU1 Spike-Mediated Infection

(2008) C. M. Chan et al.   JOURNAL OF VIROLOGY

Protease-Mediated Entry via the Endosome of Human Coronavirus 229E

(2008) M. Kawase et al.   JOURNAL OF VIROLOGY