Potential of Olive Oil Mill Wastewater as a Source of Polyphenols for the Treatment of Skin Disorders: A Review

Concentration of Bioactive Phenolic Compounds in Olive Mill Wastewater by Direct Contact Membrane Distillation

(2021) Rosa Tundis et al.   MOLECULES

Microbial Application to Improve Olive Mill Wastewater Phenolic Extracts

(2021) Flora V. Romeo et al.   MOLECULES

Ferulic acid alleviates atopic dermatitis-like symptoms in mice via its potent anti-inflammatory effect

(2020) Zhike Zhou et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Varietal Effect on the Concentration and Anti-Inflammatory Activity of Hydroxytyrosol in French Olive Oils

(2020) Ziad Almaksour et al.   JOURNAL OF MEDICINAL FOOD

Antioxidant quantification in different portions obtained during olive oil extraction process in an olive oil press mill

(2020) Alessandra De Bruno et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Olive mill wastewater treatment and valorization by extraction/concentration of hydroxytyrosol and other natural phenols

(2020) Mohammed O.J. Azzam et al.   PROCESS SAFETY AND ENVIRONMENTAL PROTECTION

Safety and efficacy of hydroxytyrosol-based formulation on skin inflammation: in vitro evaluation on reconstructed human epidermis model

(2019) Antonella Smeriglio et al.   DARU-Journal of Pharmaceutical Sciences

Ferulic acid altered IL-17A/IL-17RA interaction and protected against imiquimod-induced psoriasis-like skin injury in mice

(2019) Hsin-Yi Lo et al.   FOOD AND CHEMICAL TOXICOLOGY

Hydroxytyrosol prevents dermal papilla cells inflammation under oxidative stress by inducing autophagy

(2019) Qian Chen et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Dietary oleuropein and its new acyl-derivate, attenuate murine lupus nephritis through HO-1/Nrf2 activation and suppressing JAK/STAT, NF-κB, MAPK and NLRP3 inflammasome signaling pathways

(2019) M.L. Castejon et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Olive‐Oil‐Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF‐κB Pathway

(2019) Marina Aparicio‐Soto et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Implementation of phenols recovered from olive mill wastewater as UV booster in cosmetics

(2018) Charis M. Galanakis et al.   INDUSTRIAL CROPS AND PRODUCTS

Verbascoside Alleviates Atopic Dermatitis-Like Symptoms in Mice via Its Potent Anti-Inflammatory Effect

(2018) Yongxi Li et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Ferulic acid photoprotective properties in association with UV filters: multifunctional sunscreen with improved SPF and UVA-PF

(2018) Daniela D'Almeida Peres et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains

(2018) Małgorzata Kępa et al.   Biomed Research International

Review and Analysis of Alternatives for the Valorisation of Agro-Industrial Olive Oil By-Products

(2018) Julio Berbel et al.   Sustainability

Antioxidant Properties of Ferulic Acid and Its Possible Application

(2018) Kamila Zduńska et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Hydroxytyrosol from olive fruits prevents blue-light-induced damage in human keratinocytes and fibroblasts

(2018) Rosanna Avola et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies

(2018) Jessica Ruzzolini et al.   Nutrients

Valorisation of olive mill wastewater by phenolic compounds adsorption: Development and application of a procedure for adsorbent selection

(2018) Dario Frascari et al.   CHEMICAL ENGINEERING JOURNAL

Recovery and stability over time of phenolic fractions by an industrial filtration system of olive mill wastewaters: a three-year study

(2017) Maria Bellumori et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Hydroxytyrosol contributes to cell proliferation and inhibits apoptosis in pulsed electromagnetic fields treated human umbilical vein endothelial cells in vitro

(2017) Yong Cheng et al.   Molecular Medicine Reports

Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2017) Wenyan Sun et al.   NEUROPHARMACOLOGY

Assessment of the antioxidant and antibacterial activities of different olive processing wastewaters

(2017) Majdouline Belaqziz et al.   PLoS One

Dietary hydroxytyrosol and hydroxytyrosyl acetate supplementation prevent pristane-induced systemic lupus erythematous in mice

(2017) Marina Aparicio-Soto et al.   Journal of Functional Foods

Oleuropein down-regulated IL-1β-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982

(2017) Maria Luisa Castejón et al.   Food & Function

Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells

(2017) Francisco J. G. Muriana et al.   Food & Function

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Pretreatment of Ferulic Acid Protects Human Dermal Fibroblasts against Ultraviolet A Irradiation

(2016) Hyung Jin Hahn et al.   Annals of Dermatology

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

(2016) Pavida Pittayapruek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR

(2016) Gilberto Silva Nunes Bezerra et al.   JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Polygonum aviculareL. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing

(2016) Seol Hwa Seo et al.   PHYTOTHERAPY RESEARCH

Hydroxytyrosol inhibits hydrogen peroxide-induced apoptotic signaling via labile iron chelation

(2016) Natalia Kitsati et al.   Redox Biology

Ferulic acid inhibits UVB-radiation induced photocarcinogenesis through modulating inflammatory and apoptotic signaling in Swiss albino mice

(2015) Kanagalakshmi Ambothi et al.   FOOD AND CHEMICAL TOXICOLOGY

Olive by-products: Challenge application in cosmetic industry

(2015) Francisca Rodrigues et al.   INDUSTRIAL CROPS AND PRODUCTS

Oleuropein Suppresses LPS-Induced Inflammatory Responses in RAW 264.7 Cell and Zebrafish

(2015) Su-Jung Ryu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tyrosol prevents apoptosis in irradiated keratinocytes

(2015) Sara Salucci et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Minimization of Local and Systemic Adverse Effects of Topical Glucocorticoids by Nanoencapsulation: In Vivo Safety of Hydrocortisone–Hydroxytyrosol Loaded Chitosan Nanoparticles

(2015) Muhammad Irfan Siddique et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protective effect of C. sativa leaf extract against UV mediated-DNA damage in a human keratinocyte cell line

(2015) I.F. Almeida et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Caffeic Acid Inhibits UVB-induced Inflammation and Photocarcinogenesis Through Activation of Peroxisome Proliferator-activated Receptor-γin Mouse Skin

(2015) Agilan Balupillai et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Multiple Biological Effects of Olive Oil By-products such as Leaves, Stems, Flowers, Olive Milled Waste, Fruit Pulp, and Seeds of the Olive Plant on Skin

(2015) Asuka Kishikawa et al.   PHYTOTHERAPY RESEARCH

Phenolic compounds from olive mill wastes: Health effects, analytical approach and application as food antioxidants

(2015) Mariana Araújo et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Effect of Tyrosol and Farnesol on Virulence and Antibiotic Resistance of Clinical Isolates ofPseudomonas aeruginosa

(2015) Shaymaa Hassan Abdel-Rhman et al.   Biomed Research International

Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin

(2015) Tao Tong et al.   PLoS One

Effect of ageing on tactile transduction processes

(2014) Johanna Decorps et al.   AGEING RESEARCH REVIEWS

Caffeic Acid Reduces Cutaneous Tumor Necrosis Factor Alpha (TNF-α), IL-6 and IL-1β Levels and Ameliorates Skin Edema in Acute and Chronic Model of Cutaneous Inflammation in Mice

(2014) Mengjun Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Photoprotection of Buddleja cordata extract against UVB-induced skin damage in SKH-1 hairless mice

(2014) José Guillermo Avila Acevedo et al.   BMC Complementary and Alternative Medicine

Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis

(2014) G. Yang et al.   Cancer Prevention Research

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Antioxidants in the prevention of UVB-induced keratynocyte apoptosis

(2014) Sara Salucci et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Coffee silverskin: A possible valuable cosmetic ingredient

(2014) Francisca Rodrigues et al.   PHARMACEUTICAL BIOLOGY

Nrf2, a Regulator of the Proteasome, Controls Self-Renewal and Pluripotency in Human Embryonic Stem Cells

(2014) Jiwon Jang et al.   STEM CELLS

Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops

(2014) Luigi Ambrosone et al.   Biomed Research International

Modulation of Human Keratinocyte Responses to Solar UV by Plant Polyphenols As a Basis for Chemoprevention of Non-Melanoma Skin Cancers

(2013) V.A. Kostyuk et al.   CURRENT MEDICINAL CHEMISTRY

Modulation of the Expression of the Proinflammatory IL-8 Gene in Cystic Fibrosis Cells by Extracts Deriving from Olive Mill Waste Water

(2013) Ilaria Lampronti et al.   Evidence-based Complementary and Alternative Medicine

Tyrosol exhibits negative regulatory effects on LPS response and endotoxemia

(2013) Jing Lu et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of pre- and post-treatment with plant polyphenols on human keratinocyte responses to solar UV

(2013) Alla I. Potapovich et al.   INFLAMMATION RESEARCH

Stress proteins in aging and life span

(2013) Ayesha Murshid et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: An ex vivo and in vivo study using an NC/Nga mouse model

(2013) Zahid Hussain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tyrosinase Inhibitors from Calceolaria integrifolia s.l.: Calceolaria talcana Aerial Parts

(2013) Evelyn Muñoz et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne

(2013) Sorel Fitz-Gibbon et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lonicera caerulea fruits reduce UVA-induced damage in hairless mice

(2013) Jitka Vostálová et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Recovery and Removal of Phenolic Compounds from Olive Mill Wastewater

(2013) Neda Rahmanian et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway

(2013) Andrzej Parzonko et al.   PHYTOMEDICINE

Olive mill wastes: Biochemical characterizations and valorization strategies

(2013) S. Dermeche et al.   PROCESS BIOCHEMISTRY

Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation

(2012) Timothy L. Scott et al.   EXPERIMENTAL DERMATOLOGY

Antioxidant activity of phenolic fractions in olive mill wastewater

(2012) Hassan Azaizeh et al.   FOOD CHEMISTRY

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging

(2012) Sarah J. Chapple et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The role of antioxidants in photoprotection: A critical review

(2012) Lucy Chen et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The fate of olive fruit phenols during commercial olive oil processing: Traditional press versus continuous two- and three-phase centrifuge

(2012) Tina Jerman Klen et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Caffeic Acid and Ferulic Acid Inhibit UVA-Induced Matrix Metalloproteinase-1 through Regulation of Antioxidant Defense System in Keratinocyte HaCaT Cells

(2012) Thanyawan Pluemsamran et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

Recovery of high added-value components from food wastes: Conventional, emerging technologies and commercialized applications

(2012) Charis M. Galanakis   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Evaluation of wound healing activity of ferulic acid in diabetic rats

(2012) Mahesh M Ghaisas et al.   International Wound Journal

Potential use of olive mill wastewater in the preparation of functional beverages: A review

(2012) Hanaa Zbakh et al.   Journal of Functional Foods

Plant Polyphenols Regulate Chemokine Expression and Tissue Repair in Human Keratinocytes Through Interaction with Cytoplasmic and Nuclear Components of Epidermal Growth Factor Receptor System

(2011) Saveria Pastore et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation

(2011) Vladimir A. Kostyuk et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synergistic Antibacterial Effects of Polyphenolic Compounds from Olive Mill Wastewater

(2011) Ahmed Tafesh et al.   Evidence-based Complementary and Alternative Medicine

Caffeic acid attenuates 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced NF-κB and COX-2 expression in mouse skin: Abrogation of oxidative stress, inflammatory responses and proinflammatory cytokine production

(2011) Abdul Quaiyoom Khan et al.   FOOD AND CHEMICAL TOXICOLOGY

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis

(2011) Haloom Rafehi et al.   Genes and Nutrition

Ferulic acid promotes endothelial cells proliferation through up-regulating cyclin D1 and VEGF

(2011) Jun Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms

(2011) Vanisree Staniforth et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation

(2011) Young-Ok Son et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Activity and Stability Studies of Verbascoside, a Novel Antioxidant, in Dermo-Cosmetic and Pharmaceutical Topical Formulations

(2011) Silvia Vertuani et al.   MOLECULES

Hydroxytyrosol Is the Major Anti-Inflammatory Compound in Aqueous Olive Extracts and Impairs Cytokine and Chemokine Production in Macrophages

(2011) Nathalie Richard et al.   PLANTA MEDICA

Fungicidal effect of hydroxytyrosol-rich preparations from olive mill wastewater against Verticillium dahliae

(2010) Thabèt Yangui et al.   CROP PROTECTION

Biological Activity of High Molecular Weight Phenolics from Olive Mill Wastewater

(2010) Angela Cardinali et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Factors Affecting Wound Healing

(2010) S. Guo et al.   JOURNAL OF DENTAL RESEARCH

Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam.

(2010) Zeliha Akdemir et al.   JOURNAL OF ETHNOPHARMACOLOGY

Wound Repair Potential of Olea europaea L. Leaf Extracts Revealed by In Vivo Experimental Models and Comparative Evaluation of the Extracts' Antioxidant Activity

(2010) Ufuk Koca et al.   JOURNAL OF MEDICINAL FOOD

Antiinflammatory effects in THP-1 cells treated with verbascoside

(2010) Lorenza Speranza et al.   PHYTOTHERAPY RESEARCH

Plant Polyphenols Effectively Protect HaCaT Cells from Ultraviolet C-Triggered Necrosis and Suppress Inflammatory Chemokine Expression

(2009) Saveria Pastore et al.   Annals of the New York Academy of Sciences

Lonicera caerulea and Vaccinium myrtillus fruit polyphenols protect HaCaT keratinocytes against UVB-induced phototoxic stress and DNA damage

(2009) Alena Svobodová et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Non-Sunscreen Photoprotection: Antioxidants Add Value to a Sunscreen

(2009) Mary S. Matsui et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Olive Leaf Extract and Its Main Component Oleuropein Prevent Chronic Ultraviolet B Radiation-Induced Skin Damage and Carcinogenesis in Hairless Mice

(2009) Yoshiyuki Kimura et al.   JOURNAL OF NUTRITION

Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1α

(2009) Chiu-Mei Lin et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice

(2009) Ho Sun Song et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Staphylococcus epidermidis — the 'accidental' pathogen

(2009) Michael Otto   NATURE REVIEWS MICROBIOLOGY

Effects of olive leaf extract and its main component oleuroepin on acute ultraviolet B irradiation-induced skin changes in C57BL/6J mice

(2009) Maho Sumiyoshi et al.   PHYTOTHERAPY RESEARCH

The protective effects of hydroxytyrosol against UVB-induced DNA damage in HaCaT cells

(2009) Wei Guo et al.   PHYTOTHERAPY RESEARCH

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Mechanism of skin pigmentation

(2008) Lam Do Phuong Uyen et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression

(2008) N. J. Kang et al.   CARCINOGENESIS

Liposomes as Carriers for Verbascoside: Stability and Skin Permeation Studies

(2008) C. Sinico et al.   JOURNAL OF LIPOSOME RESEARCH

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE

Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin

(2008) Christian Oresajo et al.   Journal of Cosmetic Dermatology

Efficacy of oleuropein against UVB irradiation: preliminary evaluation

(2008) P. Perugini et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE