Article
Biochemistry & Molecular Biology
Yanjie Wang, Ping Zhang, Jingyu Zhang, Tie Hong
Summary: The study aimed to demonstrate the effectiveness of BDMC on TNF-alpha/IFN gamma-stimulated HaCaT cells and DNCB-induced AD mice. Results showed that BDMC significantly inhibited the mRNA expression of chemokines and cytokines in stimulated HaCaT cells and alleviated their inflammatory response. In vivo studies found that BDMC significantly improved AD skin lesions, decreased symptoms, improved inflammatory cell infiltration, and inhibited signaling pathways. Further clinical studies are warranted for the treatment of AD.
Article
Plant Sciences
Xinyan Han, Ziyu Chen, Jinfeng Yuan, Gaorui Wang, Xiao Han, Hui Wu, Hailian Shi, Guixin Chou, Liu Yang, Xiaojun Wu
Summary: The study showed that Artemisia annua water extract (AWE) had a significant therapeutic effect on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, possibly by inhibiting Th2 type inflammatory response.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Zeng Zhi-wen, Huang Jin-quan, Chen Yong, Yu Xiao, Zhu Wei, Zhang Dong-shu
Summary: This study evaluated the therapeutic effects of acupoint autohemotherapy on atopic dermatitis in mice and its regulation of Th1/Th2 immune responses. The results showed that acupoint autohemotherapy can significantly alleviate symptoms, decrease serum IgE levels, and regulate the Th1/Th2 shift by increasing the expression of related transcription factors.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Food Science & Technology
Rong Wang, Haruyo Nakajima-Adachi, Yimei Wang, Yingyu Zhou, Wenting Gu, Erika Hiraide, Mamiko Morinaga, Ryogo Nakagawa, Shotaro Nakamura, Tomohiro Takano, Xuyang Li, Mayumi Saeki, Osamu Kaminuma, Takachika Hiroi, Kenji Uchida, Hidemasa Motoshima, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Lactococcus lactis subsp. cremoris YRC3780 isolated from kefir has anti-allergic effects in humans. The oral administration of L. cremoris YRC3780 enhanced IFN-gamma and IL-12 production, inhibited IL-4 production, and attenuated symptoms in an atopic dermatitis mouse model by regulating cytokine expression.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Yan Su, Yunjon Han, Hack Sun Choi, Gil-Yong Lee, Hee Won Cho, Heonsik Choi, Yong-Suk Jang, Jong Hyun Choi, Jeong-Woo Seo
Summary: The study investigated the therapeutic benefits of lipid mediators in atopic dermatitis (AD) and found that the mediators effectively reduced the production of inflammatory cytokines, inhibited the NF-kappa B signaling pathway, and altered the composition of gut microbiota. The results suggest that lipid mediators could be a potential therapeutic agent for improving AD symptoms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rebecca Riedl, Annika Kuehn, Denise Rietz, Betty Hebecker, Karl-Gunther Glowalla, Lukas K. Peltner, Paul M. Jordan, Oliver Werz, Stefan Lorkowski, Cornelia Wiegand, Maria Wallert
Summary: This study established a DNCB-induced mouse model of AD with a detailed procedure description and classification of the AD human-like skin type. The model displayed various pathological changes associated with AD, such as thickening of the skin layers, altered skin barrier proteins, increased cytokine expression, and dysregulated gene expression. Additionally, increased mast cell infiltration and elevated IgE and histamine levels were observed, indicating a link to type I allergy reactions. Overall, this model mimics the features of a mild human-like extrinsic AD in murine skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yi Tang, Ma Li, Yixin Su, Yue Du, Xia Wu, Xianzhen Chen, Yinjing Song, Lihua Lai, Hao Cheng
Summary: In this study, integrated transcriptomic and metabolomic analyses were used to study the potential mechanisms of DNCB-induced AD-like skin lesions. DNCB was found to induce AD-like skin lesions in mice, and alterations in transcription and metabolism were observed. A total of 3413 differentially expressed metabolites were detected between DNCB-induced AD-like mice and healthy controls, and the expression of genes associated with metabolic pathways was significantly altered. These findings provide insights into the possible mechanism of AD and potential targets for drug development.
Article
Plant Sciences
Hwa Pyoung Lee, Wooram Choi, Ki Woong Kwon, Long You, Laily Rahmawati, Van Dung Luong, Wonhee Kim, Byoung-Hee Lee, Sarah Lee, Ji Hye Kim, Jae Youl Cho
Summary: This study evaluates the anti-allergic and anti-topical dermatitis activity of Grewia tomentosa Juss. ethanol extract (Gt-EE). The results show that Gt-EE suppressed allergic responses and inflammation, indicating its potential as a medicinal herb.
Article
Biochemistry & Molecular Biology
Ga-Yul Min, Tae In Kim, Ji-Hye Kim, Won-Kyung Cho, Ju-Hye Yang, Jin Yeul Ma
Summary: This study aimed to evaluate the effects of Isatidis folium water extract (WIF) on atopic dermatitis (AD) and investigate the underlying mechanism. The results showed that oral administration of WIF reduced AD-like symptoms in mice and suppressed the production of proinflammatory cytokines and chemokines in HaCaT cells. These findings suggest that WIF may be a potential candidate for AD treatment by inhibiting the nuclear factor-κB pathway and reducing inflammation.
Article
Endocrinology & Metabolism
Qiao Li, Yanyun Shen, Zhidong Zhu
Summary: Salubrinal alleviated atopic dermatitis induced by DNCB by suppressing inflammation, ER stress, and oxidative stress via attenuation of the NF-KB/NLRP3 axis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
Zhehuan Wang, Huiru Zhang, Caihong Qi, Hui Guo, Xiangyue Jiao, Jia Yan, Yifei Wang, Qiangsheng Li, Mingming Zhao, Xinhao Guo, Baoluo Wan, Xiaotian Li
Summary: The study found that ursolic acid (UA) has a therapeutic effect on atopic dermatitis (AD) mice, potentially by inhibiting the TLR4/NF-kappa B pathway and activating the Nrf2/HO-1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Axel P. Villani, Ana B. Pavel, Jianni Wu, Marie Fernandes, Catherine Maari, Etienne Saint-Cyr Proulx, Carolyn Jack, Jacob Glickman, Seulah Choi, Helen He, Benjamin Ungar, Yeriel Estrada, Naoya Kameyama, Ning Zhang, Juana Gonzales, Jean-Claude Tardif, James G. Krueger, Robert Bissonnette, Emma Guttman-Yassky
Summary: The study found significant correlations between vascular inflammation and Th2-related products in the skin and blood of AD patients, as well as atherosclerosis-related markers modulated by dupilumab. Circulating levels of endothelial microparticles were significantly higher in severe AD patients and tended to correlate with vascular inflammation.
Article
Plant Sciences
Du Hyeon Hwang, Phil-Ok Koh, Changkeun Kang, Euikyung Kim
Summary: The study showed that Rosa davurica Pall. leaves have significant anti-inflammatory effects on atopic dermatitis by reducing the release of inflammatory mediators, decreasing inflammation reactions, and modulating skin inflammation. This indicates that Rosa davurica Pall. may serve as a potential alternative therapeutic treatment for skin disorders like atopic dermatitis.
Article
Biochemistry & Molecular Biology
Saeko Nakajima, Duerna Tie, Takashi Nomura, Kenji Kabashima
Summary: Type 2 immunity and inflammation play key roles in allergic skin disorders like atopic dermatitis, with cytokines such as IL-4 and IL-13 being essential in type 2 inflammation. Biologics targeting these cytokines have shown significant efficacy in treating AD, based on both basic research in mice and clinical trials in humans.
Article
Plant Sciences
Hai Rong Zeng, Bei Zhao, Xing Rui, Gui Hua Jia, Yue Wu, Die Zhang, Hao Nao Yu, Ben Rui Zhang, Yi Yuan
Summary: The study showed that VYAC effectively improved skin symptoms and reduced inflammation in a mouse model of atopic dermatitis, inhibiting mast cell degranulation, indicating its therapeutic potential for skin diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)