Aptamers and Their Applications in Nanomedicine

Selective Uptake and Imaging of Aptamer- and Antibody-Conjugated Hollow Nanospheres Targeted to Epidermal Growth Factor Receptors Overexpressed in Head and Neck Cancer

(2014) Marites Pasuelo Melancon et al.   ACS Nano

A novel aptamer functionalized CuInS2 quantum dots probe for daunorubicin sensing and near infrared imaging of prostate cancer cells

(2014) Zihan Lin et al.   ANALYTICA CHIMICA ACTA

Monoclonal Surface Display SELEX for Simple, Rapid, Efficient, and Cost-Effective Aptamer Enrichment and Identification

(2014) Zhi Zhu et al.   ANALYTICAL CHEMISTRY

Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy

(2014) Yinan Zhong et al.   BIOMACROMOLECULES

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

(2014) Liyu Li et al.   BIOMATERIALS

Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells

(2014) Fujian Huang et al.   CHEMICAL COMMUNICATIONS

Nanopharmaceuticals (part 1): products on the market

(2014) Volkmar Weissig et al.   International Journal of Nanomedicine

Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery

(2014) Phapanin Charoenphol et al.   MOLECULAR PHARMACEUTICS

Inhibition of Receptor Signaling and of Glioblastoma-derived Tumor Growth by a Novel PDGFRβ Aptamer

(2014) Simona Camorani et al.   MOLECULAR THERAPY

DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics

(2014) Alfonso Latorre et al.   Nanoscale

Au@Ag/Au nanoparticles assembled with activatable aptamer probes as smart “nano-doctors” for image-guided cancer thermotherapy

(2014) Hui Shi et al.   Nanoscale

Maleimidyl magnetic nanoplatform for facile molecular MRI

(2014) Dan Heo et al.   NANOTECHNOLOGY

Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

(2014) Hongguang Sun et al.   Molecular Therapy-Nucleic Acids

One-Pot Synthesized Aptamer-Functionalized CdTe:Zn2+ Quantum Dots for Tumor-Targeted Fluorescence Imaging in Vitro and in Vivo

(2013) Cuiling Zhang et al.   ANALYTICAL CHEMISTRY

Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer

(2013) Parag Parekh et al.   BIOMATERIALS

Bioimaging of targeting cancers using aptamer-conjugated carbon nanodots

(2013) Chang Hyun Lee et al.   CHEMICAL COMMUNICATIONS

Aptamer-Conjugated Nanorods for Targeted Photothermal Therapy of Prostate Cancer Stem Cells

(2013) Jian Wang et al.   Chemistry-An Asian Journal

Update on current and potential nanoparticle cancer therapies

(2013) Jonathan S. Rink et al.   CURRENT OPINION IN ONCOLOGY

Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)

(2013) Rong Tong et al.   CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE

Investigation on novel chitosan nanoparticle–aptamer complexes targeting TGF-β receptor II

(2013) Xia Chen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeted delivery of Epirubicin to cancer cells by PEGylated A10 aptamer

(2013) Seyed Mohammad Taghdisi et al.   JOURNAL OF DRUG TARGETING

Targeted in vitro photodynamic therapy via aptamer-labeled, porphyrin-loaded virus capsids

(2013) Brian A. Cohen et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Highly efficient inhibition of human immunodeficiency virus type 1 reverse transcriptase by aptamers functionalized gold nanoparticles

(2013) Yen-Chun Shiang et al.   Nanoscale

Selective Light-Triggered Release of DNA from Gold Nanorods Switches Blood Clotting On and Off

(2013) Helena de Puig et al.   PLoS One

An Ultra pH-Sensitive and Aptamer-Equipped Nanoscale Drug-Delivery System for Selective Killing of Tumor Cells

(2013) Nianxi Zhao et al.   Small

Photosensitizer-Gold Nanorod Composite for Targeted Multimodal Therapy

(2013) Jian Wang et al.   Small

Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells

(2013) Francoise A. Gourronc et al.   VIROLOGY

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

(2013) Hang Xing et al.   Journal of Materials Chemistry B

Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature

(2013) Bongjune Kim et al.   Nanoscale Research Letters

Aptamer-Functionalized Nanoparticles for Medical Applications: Challenges and Opportunities

(2012) Zeyu Xiao et al.   ACS Nano

Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors

(2012) Li Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Properties of an ‘LNA’-modified ricin RNA aptamer

(2012) Charlotte Förster et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

X-Aptamers: A Bead-Based Selection Method for Random Incorporation of Druglike Moieties onto Next-Generation Aptamers for Enhanced Binding

(2012) Weiguo He et al.   BIOCHEMISTRY

Targeting cancer cells with controlled release nanocapsules based on a single aptamer

(2012) Frank J. Hernandez et al.   CHEMICAL COMMUNICATIONS

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

ATP-Responsive Controlled Release System Using Aptamer-Functionalized Mesoporous Silica Nanoparticles

(2012) Xiaoxiao He et al.   LANGMUIR

Impact of Intestinal PepT1 on the Kinetics and Dynamics of N-Formyl-Methionyl-Leucyl-Phenylalanine, a Bacterially-Produced Chemotactic Peptide

(2012) Shu-Pei Wu et al.   MOLECULAR PHARMACEUTICS

Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers

(2012) Farzin Haque et al.   Nano Today

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

(2012) Kristina W. Thiel et al.   NUCLEIC ACIDS RESEARCH

Rapid Identification of Cell-Specific, Internalizing RNA Aptamers with Bioinformatics Analyses of a Cell-Based Aptamer Selection

(2012) William H. Thiel et al.   PLoS One

An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

(2012) Samantha E Wilner et al.   Molecular Therapy-Nucleic Acids

Current Progress of RNA Aptamer-Based Therapeutics

(2012) Jiehua Zhou et al.   Frontiers in Genetics

In Vitro Selection of DNA Aptamers to Glioblastoma Multiforme

(2011) Abdullah Tahir Bayrac et al.   ACS Chemical Neuroscience

Polymer therapeutics as nanomedicines: new perspectives

(2011) Ruth Duncan   CURRENT OPINION IN BIOTECHNOLOGY

Population Pharmacokinetics of Pegaptanib in Patients With Neovascular, Age-Related Macular Degeneration

(2011) Anthony S. Basile et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer

(2011) Ronak Savla et al.   JOURNAL OF CONTROLLED RELEASE

Bioresponsive Controlled Release Using Mesoporous Silica Nanoparticles Capped with Aptamer-Based Molecular Gate

(2011) Chun-Ling Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PEGylated Anti-MUC1 Aptamer-Doxorubicin Complex for Targeted Drug Delivery to MCF7 Breast Cancer Cells

(2011) Lihan Tan et al.   MACROMOLECULAR BIOSCIENCE

Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 Inhibition

(2011) Jiehua Zhou et al.   METHODS

Nanomedicine(s) under the Microscope

(2011) Ruth Duncan et al.   MOLECULAR PHARMACEUTICS

Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

(2011) Dan Shu et al.   Nature Nanotechnology

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

From SOMAmer-Based Biomarker Discovery to Diagnostic and Clinical Applications: A SOMAmer-Based, Streamlined Multiplex Proteomic Assay

(2011) Stephan Kraemer et al.   PLoS One

Image-Guided Prostate Cancer Therapy Using Aptamer-Functionalized Thermally Cross-Linked Superparamagnetic Iron Oxide Nanoparticles

(2011) Mi Kyung Yu et al.   Small

A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma

(2011) Nianxi Zhao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Aptamers Recognizing Glycosylated Hemagglutinin Expressed on the Surface of Vaccinia Virus-Infected Cells

(2010) Parag Parekh et al.   ANALYTICAL CHEMISTRY

A Temperature-Responsive Antibody-Like Nanostructure

(2010) Jing Zhou et al.   BIOMACROMOLECULES

Reversible Targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes

(2010) Seyed Mohammad Taghdisi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

(2010) Günter Mayer et al.   Nature Protocols

Pitfalls of Cell-Systematic Evolution of Ligands by Exponential Enrichment (SELEX): Existing Dead Cells During In Vitro Selection Anticipate the Enrichment of Specific Aptamers

(2010) Meltem Avci-Adali et al.   OLIGONUCLEOTIDES

Generating Aptamers for Recognition of Virus-Infected Cells

(2009) Z. Tang et al.   CLINICAL CHEMISTRY

Identification of an aptamer targeting hnRNP A1 by tissue slide‐based SELEX

(2009) Shaohua Li et al.   JOURNAL OF PATHOLOGY

Molecular recognition of acute myeloid leukemia using aptamers

(2009) K Sefah et al.   LEUKEMIA

A Hybrid DNA Aptamer-Dendrimer Nanomaterial for Targeted Cell Labeling

(2009) Jing Zhou et al.   MACROMOLECULAR BIOSCIENCE

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells

(2009) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamer-Targeted Gold Nanoparticles As Molecular-Specific Contrast Agents for Reflectance Imaging

(2008) David J. Javier et al.   BIOCONJUGATE CHEMISTRY

Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy

(2008) Andrew Z. Wang et al.   ChemMedChem

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes

(2008) Zhi Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY