Genetics and Inflammation in Endometriosis: Improving Knowledge for Development of New Pharmacological Strategies

Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target

(2021) Chiara Agostinis et al.   Frontiers in Immunology

The role of mitogen‐activated protein kinase signaling pathway in endometriosis

(2021) Gizem Bora et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Macrophages inhibit and enhance endometriosis depending on their origin

(2021) Chloe Hogg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review

(2021) Jacques Donnez et al.   Journal of Clinical Medicine

Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation

(2021) E Giacomini et al.   HUMAN REPRODUCTION

Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing

(2021) Imane Lalami et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Targeting Wnt/β‐catenin and PI3K/Akt/mTOR pathways in T‐cell acute lymphoblastic leukemia

(2020) Cecilia Evangelisti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Analysis of exosomal lncRNA, miRNA and mRNA expression profiles and ceRNA network construction in endometriosis

(2020) Jingni Wu et al.   Epigenomics

Involvement of p38 MAPK in Synaptic Function and Dysfunction

(2020) Chiara Falcicchia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterizing Extracellular Vesicles and Their Diverse RNA Contents

(2020) Eren M. Veziroglu et al.   Frontiers in Genetics

Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis

(2020) Wan-Ning Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-regulation of Exosomal miR-214-3p Targeting CCN2 Contributes to Endometriosis Fibrosis and the Role of Exosomes in the Horizontal Transfer of miR-214-3p

(2020) Yanqin Zhang et al.   Reproductive Sciences

Extracellular Vesicles: From Biomarkers to Therapeutic Tools

(2020) Simona Bernardi et al.   Biology-Basel

Exosomes from different cells: Characteristics, modifications, and therapeutic applications

(2020) Mingyuan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive analysis utilizing flow cytometry and immunohistochemistry reveals inflammatory changes in local endometrial and systemic dendritic cell populations in endometriosis

(2020) A J Hey-Cunningham et al.   HUMAN REPRODUCTION

Lipoxin A4 Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis

(2019) Songjuan Dai et al.   Reproductive Sciences

Endometriosis

(2019) Serdar E Bulun et al.   ENDOCRINE REVIEWS

Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation

(2019) Wook-Jin Chae et al.   DIFFERENTIATION

A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer

(2019) S. Lindsey Davis et al.   INVESTIGATIONAL NEW DRUGS

A phase 1b dose escalation study of ipafricept (OMP 54F28) in combination with paclitaxel and carboplatin in patients with recurrent platinum-sensitive ovarian cancer

(2019) Kathleen N. Moore et al.   GYNECOLOGIC ONCOLOGY

Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review

(2019) Paola Viganò et al.   Journal of Minimally Invasive Gynecology

The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease

(2019) John Papaconstantinou   Cells

Immunology of endometriosis

(2018) Luiza da Gama Coelho Riccio et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Medical treatment of endometriosis-related pain

(2018) Paolo Vercellini et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

IL-37 affects the occurrence and development of endometriosis by regulating the biological behavior of endometrial stromal cells through multiple signaling pathways

(2018) Jianfa Jiang et al.   BIOLOGICAL CHEMISTRY

Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis

(2018) Shunichi Fujita et al.   BONE

Discovery and optimization of 1-(1 H -indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer

(2018) Qiuping Xiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The assessment of GWAS — identified polymorphisms associated with infertility risk in Polish women with endometriosis

(2018) Maciej Osiński et al.   Ginekologia Polska

Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis

(2018) T Heinosalo et al.   HUMAN REPRODUCTION

Efficacy, safety and recurrence of new progestins and selective progesterone receptor modulator for the treatment of endometriosis: a comparison study in mice

(2018) Bo Liang et al.   Reproductive Biology and Endocrinology

Endometriosis

(2018) Krina T. Zondervan et al.   Nature Reviews Disease Primers

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties

(2018) Zvezdan Pavlovic et al.   mAbs

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

(2018) Wen Liao et al.   Acta Biomaterialia

Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis

(2017) Outi Uimari et al.   HUMAN REPRODUCTION

Overexpression of long noncoding RNA, NEAT1 promotes cell proliferation, invasion and migration in endometrial endometrioid adenocarcinoma

(2016) Zhiguo Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Immune-inflammation gene signatures in endometriosis patients

(2016) Soo Hyun Ahn et al.   FERTILITY AND STERILITY

Endometrial vezatin and its association with endometriosis risk

(2016) Sarah J. Holdsworth-Carson et al.   HUMAN REPRODUCTION

Association of interleukin-16 polymorphisms with disease progression and susceptibility in endometriosis

(2016) P. Azimzadeh et al.   International Journal of Immunogenetics

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

17 β-Estradiol promotes vascular endothelial growth factor expression via the Wnt/β-catenin pathway during the pathogenesis of endometriosis

(2016) Ling Zhang et al.   MOLECULAR HUMAN REPRODUCTION

Immunoadolescence: Neuroimmune development and adolescent behavior

(2016) Heather C. Brenhouse et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling

(2016) So-Young Hwang et al.   Cell Reports

A Small-Molecule Antagonist of the  -Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis

(2015) L. Fang et al.   CANCER RESEARCH

SL4, a chalcone-based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway

(2015) L.-H. Wang et al.   CELL PROLIFERATION

H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis

(2015) Sanaz Ghazal et al.   EMBO Molecular Medicine

Association of WNT4 polymorphisms with endometriosis in infertile patients

(2015) Fernanda Mafra et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies

(2015) Ke Yang et al.   LABORATORY INVESTIGATION

Association of FCRL3 Genetic Polymorphisms With Endometriosis-Related Infertility Risk

(2015) Haiyan Zhang et al.   MEDICINE

Inhibition of MAPK and VEGFR by Sorafenib Controls the Progression of Endometriosis

(2015) Mahaut Leconte et al.   Reproductive Sciences

Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models

(2015) Stephen S. Palmer et al.   Reproductive Sciences

Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications

(2015) Julieta De Toro et al.   Frontiers in Immunology

Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation

(2015) Lucas T. Woods et al.   PLoS One

Lipoxin A4suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway

(2014) Rongfeng Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

(2014) N. Rahmioglu et al.   HUMAN MOLECULAR GENETICS

Association between endometriosis and the interleukin 1A (IL1A) locus

(2014) Yadav Sapkota et al.   HUMAN REPRODUCTION

Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets

(2014) Nilufer Rahmioglu et al.   HUMAN REPRODUCTION UPDATE

The multilayered complexity of ceRNA crosstalk and competition

(2014) Yvonne Tay et al.   NATURE

The development of immunoconjugates for targeted cancer therapy

(2014) Brandon G. Smaglo et al.   Nature Reviews Clinical Oncology

VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis

(2013) A. K. Alitalo et al.   CANCER RESEARCH

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

(2013) Amanda N. Kallen et al.   MOLECULAR CELL

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Endometriosis: pathogenesis and treatment

(2013) Paolo Vercellini et al.   Nature Reviews Endocrinology

Endometriosis, a disease of the macrophage

(2013) Annalisa Capobianco   Frontiers in Immunology

Raf-1, a Potential Therapeutic Target, Mediates Early Steps in Endometriosis Lesion Development by Endometrial Epithelial and Stromal Cells

(2012) Elizabeth M. De La Garza et al.   ENDOCRINOLOGY

TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility

(2012) Carla Peluso et al.   HUMAN IMMUNOLOGY

Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis

(2012) John Mark P. Pabona et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-wide association meta-analysis identifies new endometriosis risk loci

(2012) Dale R Nyholt et al.   NATURE GENETICS

Wnt/ -Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields

(2012) D. Guardavaccaro et al.   Science Signaling

Wnt/ -Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma

(2012) T. L. Biechele et al.   Science Signaling

Ras Stabilization Through Aberrant Activation of Wnt/ -Catenin Signaling Promotes Intestinal Tumorigenesis

(2012) W.-J. Jeong et al.   Science Signaling

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Secreted-frizzled related protein 1 is a transcriptional repression target of the t(8;21) fusion protein in acute myeloid leukemia

(2011) C. K. Cheng et al.   BLOOD

Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis

(2011) I.Y. Yotova et al.   HUMAN REPRODUCTION

Gene expression profiling of peripheral blood mononuclear cells in endometriosis identifies genes altered in non-gynaecologic chronic inflammatory diseases

(2011) D. Gentilini et al.   HUMAN REPRODUCTION

Matrix metalloproteinases are elevated in the urine of patients with endometriosis

(2010) Christian M. Becker et al.   FERTILITY AND STERILITY

Reactive Oxygen Species Controls Endometriosis Progression

(2009) Charlotte Ngô et al.   AMERICAN JOURNAL OF PATHOLOGY

Wnt signaling in development and disease

(2009) Jennifer L. Freese et al.   NEUROBIOLOGY OF DISEASE

Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo

(2009) David R. Brigstock   Journal of Cell Communication and Signaling

FR167653, a p38 mitogen-activated protein kinase inhibitor, aggravates experimental colitis in mice

(2008) Takashi Nishimura et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Transcript profile and localization of Wnt signaling–related molecules in human endometrium

(2007) Ching-wen Cheng et al.   FERTILITY AND STERILITY