Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Resistance to multikinase inhibitor actions mediated by insulin like growth factor-1

(2015) Catia Lippolis et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells

(2015) Martina Broecker-Preuss et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers

(2015) Chong-kui Sun et al.   Oncotarget

Biglycan enhances gastric cancer invasion by activating FAK signaling pathway

(2015) Lei Hu et al.   Oncotarget

NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling

(2015) Cuixiang Zhang et al.   Oncotarget

The clinical relevance of KRAS gene mutation in non-small-cell lung cancer

(2014) József Tímár   CURRENT OPINION IN ONCOLOGY

EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition

(2014) Virginia Rotella et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment

(2014) Maria Lehmann et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Antitumor activity of selective MEK1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models

(2014) Yiqing Qu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Alternative Mammalian Target of Rapamycin (mTOR) Signal Activation in Sorafenib-resistant Hepatocellular Carcinoma Cells Revealed by Array-based Pathway Profiling

(2014) Mari Masuda et al.   MOLECULAR & CELLULAR PROTEOMICS

Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression

(2014) Nicolle M. Linnerth-Petrik et al.   PLoS One

Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014

(2013) Hai-zhong Huo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer

(2013) A. Khalaileh et al.   CANCER RESEARCH

XRCC3 Thr241Met gene polymorphisms and lung cancer risk: a meta-analysis

(2013) Ping Zhan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mammalian target of rapamycin signaling activation patterns in pancreatic neuroendocrine tumors

(2013) Yoko Komori et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season

(2013) Grant P Parnell et al.   Multiple Sclerosis Journal

Acute ketamine-induced neuroplasticity

(2013) Vincenzo Tedesco et al.   NEUROREPORT

The combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro

(2013) Marie N. Becker et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Immunohistochemical studies of organic anion transporters and urate transporter 1 expression in human salivary gland

(2012) Ryuichi Ikarashi et al.   ACTA ODONTOLOGICA SCANDINAVICA

Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer

(2012) Zhi-Xin Qiu et al.   CANCER SCIENCE

Functional drug–gene interactions in lung cancer

(2012) Michal Smida et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Reduced Ribosomal Protein S6 Phosphorylation After Progressive Resistance Exercise in Growing Adolescent Rats

(2012) Nathan J. Hellyer et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma

(2012) Seok-Hyung Kim et al.   MODERN PATHOLOGY

Ribosomal Protein S6 Phosphorylation is Associated with Epithelial Dysplasia and Squamous Cell Carcinoma of the Oral Cavity

(2012) Risa Chaisuparat et al.   PATHOLOGY & ONCOLOGY RESEARCH

Specific Roles of Akt iso Forms in Apoptosis and Axon Growth Regulation in Neurons

(2012) Hector Diez et al.   PLoS One

Striatal Cholinergic Interneurons Display Activity-Related Phosphorylation of Ribosomal Protein S6

(2012) Jesus Bertran-Gonzalez et al.   PLoS One

TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast

(2012) W. Du et al.   Biology Open

Proteomic and biochemical analyses reveal the activation of unfolded protein response, ERK-1/2 and ribosomal protein S6 signaling in experimental autoimmune myocarditis rat model

(2011) Joo Hee Chung et al.   BMC GENOMICS

Single-Cell Pharmacodynamic Monitoring of S6 Ribosomal Protein Phosphorylation in AML Blasts during a Clinical Trial Combining the mTOR Inhibitor Sirolimus and Intensive Chemotherapy

(2011) A. E. Perl et al.   CLINICAL CANCER RESEARCH

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Haloperidol Regulates the State of Phosphorylation of Ribosomal Protein S6 via Activation of PKA and Phosphorylation of DARPP-32

(2011) Emmanuel Valjent et al.   NEUROPSYCHOPHARMACOLOGY

The Putative RNA Helicase HELZ Promotes Cell Proliferation, Translation Initiation and Ribosomal Protein S6 Phosphorylation

(2011) Philippe A. Hasgall et al.   PLoS One

Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244

(2010) M. Rosner et al.   AMINO ACIDS

Novel functions of ribosomal protein S6 in growth and differentiation of Dictyostelium cells

(2010) Kazutaka Ishii et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Targeting p70S6K Prevented Lung Metastasis in a Breast Cancer Xenograft Model

(2010) U. Akar et al.   MOLECULAR CANCER THERAPEUTICS

Tubers and tumors: rapamycin therapy for benign and malignant tumors

(2009) David R Plas et al.   CURRENT OPINION IN CELL BIOLOGY

MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells

(2009) R. J. Salmond et al.   JOURNAL OF IMMUNOLOGY

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling