Brain Mechanisms of COVID-19-Sleep Disorders

Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?

(2021) Susan M. Burks et al.   BRAIN BEHAVIOR AND IMMUNITY

The role of Neuropilin-1 in COVID-19

(2021) Bindu S. Mayi et al.   PLoS Pathogens

The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China

(2020) David S. Hui et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The Prostaglandin D2 Receptor CRTH2 Promotes IL-33–Induced ILC2 Accumulation in the Lung

(2020) Oyebola O. Oyesola et al.   JOURNAL OF IMMUNOLOGY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

18FDG PET/CT Scan Reveals Hypoactive Orbitofrontal Cortex in Anosmia of COVID-19

(2020) Mahboobeh Karimi-Galougahi et al.   ACADEMIC RADIOLOGY

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

(2020) Abdul Mannan Baig et al.   ACS Chemical Neuroscience

Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19

(2020) Luca Steardo et al.   Acta Physiologica

Sleep loss disrupts pericyte-brain endothelial cell interactions impairing blood-brain barrier function

(2020) Fernanda Medina-Flores et al.   BRAIN BEHAVIOR AND IMMUNITY

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Neurological manifestations in COVID‐19 caused by SARS‐CoV‐2

(2020) Abdul Mannan Baig   CNS Neuroscience & Therapeutics

COVID-19 cytokine storm: The anger of inflammation

(2020) Mehdi Mahmudpour et al.   CYTOKINE

COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

(2020) Toshio Hirano et al.   IMMUNITY

Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)

(2020) Alberto Paniz‐Mondolfi et al.   JOURNAL OF MEDICAL VIROLOGY

Dealing with sleep problems during home confinement due to the COVID‐19 outbreak: Practical recommendations from a task force of the European CBT‐I Academy

(2020) Ellemarije Altena et al.   JOURNAL OF SLEEP RESEARCH

Changes in sleep pattern, sense of time and digital media use during COVID‐19 lockdown in Italy

(2020) Nicola Cellini et al.   JOURNAL OF SLEEP RESEARCH

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Translating IL-6 biology into effective treatments

(2020) Ernest H. Choy et al.   Nature Reviews Rheumatology

Sleep disturbances among medical workers during the outbreak of COVID-2019

(2020) S Wang et al.   OCCUPATIONAL MEDICINE-OXFORD

The enemy who sealed the world: Effects quarantine due to the COVID-19 on sleep quality, anxiety, and psychological distress in the Italian population

(2020) Maria Casagrande et al.   SLEEP MEDICINE

Perceived stress and sleep quality among the non-diseased general public in China during the 2019 coronavirus disease: a moderated mediation model

(2020) Xiaolin Zhao et al.   SLEEP MEDICINE

A Nationwide Survey of Psychological Distress among Italian People during the COVID-19 Pandemic: Immediate Psychological Responses and Associated Factors

(2020) Cristina Mazza et al.   International Journal of Environmental Research and Public Health

Survey of Insomnia and Related Social Psychological Factors Among Medical Staff Involved in the 2019 Novel Coronavirus Disease Outbreak

(2020) Chenxi Zhang et al.   Frontiers in Psychiatry

Anosmia in COVID-19 Associated with Injury to the Olfactory Bulbs Evident on MRI

(2020) M.F.V.V. Aragão et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

Extended detrended fluctuation analysis of electroencephalograms signals during sleep and the opening of the blood–brain barrier

(2020) A. N. Pavlov et al.   CHAOS

Cerebrospinal fluid features in SARS-CoV-2 RT-PCR positive patients

(2020) Mathilde Bellon et al.   CLINICAL INFECTIOUS DISEASES

Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system

(2020) S.B. Alam et al.   EUROPEAN JOURNAL OF NEUROLOGY

SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms

(2020) Manuela Pennisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

(2020) Bingwen Liu et al.   JOURNAL OF AUTOIMMUNITY

Impact of COVID-19 lockdown on sleep quality in university students and administration staff

(2020) Sara Marelli et al.   JOURNAL OF NEUROLOGY

Sleep of preschoolers during the coronavirus disease 2019 (COVID‐19) outbreak

(2020) Zhijun Liu et al.   JOURNAL OF SLEEP RESEARCH

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

(2020) Maryam Sharifian Dorche et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

COVID-19 and anosmia in Tehran, Iran

(2020) Sapideh Gilani et al.   MEDICAL HYPOTHESES

Therapeutic Delivery to the Brain via the Lymphatic Vasculature

(2020) Pengfei Zhao et al.   NANO LETTERS

Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey

(2020) Yeen Huang et al.   PSYCHIATRY RESEARCH

COVID-19, anxiety, sleep disturbances and suicide

(2020) Leo Sher   SLEEP MEDICINE

Sera of elderly obstructive sleep apnea patients alter blood–brain barrier integrity in vitro: a pilot study

(2020) Anne-Cloé Voirin et al.   Scientific Reports

Disentangling the Hypothesis of Host Dysosmia and SARS-CoV-2: The Bait Symptom That Hides Neglected Neurophysiological Routes

(2020) Matteo Briguglio et al.   Frontiers in Physiology

The prevalence of depression, anxiety, and sleep disturbances in COVID‐19 patients: a meta‐analysis

(2020) Jiawen Deng et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Extended detrended fluctuation analysis of sound-induced changes in brain electrical activity

(2020) A.N. Pavlov et al.   CHAOS SOLITONS & FRACTALS

Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer’s Disease and the Blood-Brain Barrier

(2020) Oxana Semyachkina-Glushkovskaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection

(2020) Rafal Butowt et al.   NEUROSCIENTIST

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status

(2020) Narasimha M. Beeraka et al.   Frontiers in Immunology

Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity

(2020) Akihiro Shimba et al.   Frontiers in Immunology

Sleep research in 2020: COVID-19-related sleep disorders

(2020) Markku Partinen   LANCET NEUROLOGY

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

(2020) Tetyana P. Buzhdygan et al.   NEUROBIOLOGY OF DISEASE

Phenomenon of music-induced opening of the blood-brain barrier in healthy mice

(2020) O. Semyachkina-Glushkovskaya et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Sleep Deprivation Induces Cognitive Impairment by Increasing Blood-Brain Barrier Permeability via CD44

(2020) Jing Sun et al.   Frontiers in Neurology

Physical activity, dietary habits and sleep quality before and during COVID-19 lockdown: A longitudinal study

(2020) Óscar Martínez-de-Quel et al.   APPETITE

Sleep problems during the COVID-19 pandemic by population: a systematic review and meta-analysis

(2020) Haitham Jahrami et al.   Journal of Clinical Sleep Medicine

The impact of glucocorticoids and statins on sleep quality

(2020) Bartosz Szmyd et al.   SLEEP MEDICINE REVIEWS

A systematic review of COVID-19 and obstructive sleep apnoea

(2020) Michelle A. Miller et al.   SLEEP MEDICINE REVIEWS

Biophotonic Strategies of Measurement and Stimulation of the Cranial and the Extracranial Lymphatic Drainage Function

(2020) Oxana Semyachkina-Glushkovskaya et al.   IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

(2019) Lauren M. Hablitz et al.   Science Advances

Post-Traumatic Stress among Evacuees from the 2016 Fort McMurray Wildfires: Exploration of Psychological and Sleep Symptoms Three Months after the Evacuation

(2019) Genevieve Belleville et al.   International Journal of Environmental Research and Public Health

Regulation of the Blood–Brain Barrier by Circadian Rhythms and Sleep

(2019) Vishnu Anand Cuddapah et al.   TRENDS IN NEUROSCIENCES

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

(2019) Nina E. Fultz et al.   SCIENCE

Mechanism of the neuroprotective effect of injecting brain cells on ST36 in an animal model of Parkinson’s disease

(2019) Jongbeom Song et al.   NEUROSCIENCE LETTERS

The yin/yang of inflammatory status: Blood-brain barrier regulation during sleep

(2018) G. Hurtado-Alvarado et al.   BRAIN BEHAVIOR AND IMMUNITY

A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux

(2018) Shirley L. Zhang et al.   CELL

Photodynamic opening of the blood-brain barrier and pathways of brain clearing

(2018) Oxana Semyachkina-Glushkovskaya et al.   Journal of Biophotonics

Evidence supporting a role for astrocytes in the regulation of cognitive flexibility and neuronal oscillations through the Ca2+ binding protein S100β

(2018) Adam T. Brockett et al.   PLoS One

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease

(2018) Andrew Harkin et al.   Neural Regeneration Research

Safety of Gadolinium Administration in Children

(2018) Ismail Elbeshlawi et al.   PEDIATRIC NEUROLOGY

Astrocytic modulation of cortical oscillations

(2018) Alba Bellot-Saez et al.   Scientific Reports

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

(2018) Qiaoli Ma et al.   ACTA NEUROPATHOLOGICA

Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation

(2018) Jovana Maric et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome

(2018) Verena Staedtke et al.   NATURE

Chronic sleep restriction disrupts interendothelial junctions in the hippocampus and increases blood-brain barrier permeability

(2017) G. HURTADO-ALVARADO et al.   JOURNAL OF MICROSCOPY

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET

(2017) Mony J. de Leon et al.   JOURNAL OF NUCLEAR MEDICINE

Is C-reactive protein a marker of obstructive sleep apnea?

(2017) Kun Li et al.   MEDICINE

Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior

(2017) Samantha J. Hindle et al.   Cell Reports

Real-time monitoring of human blood-brain barrier disruption

(2017) Vesa Kiviniemi et al.   PLoS One

Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms

(2016) Moshe Rogosnitzky et al.   BIOMETALS

The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea

(2016) David J Durgan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease

(2016) Bogusz Trojanowicz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Blood-Brain Barrier

(2016) Weihong Pan et al.   NEUROSCIENTIST

Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link

(2016) G. Hurtado-Alvarado et al.   Journal of Immunology Research

A2A Adenosine Receptor Antagonism Reverts the Blood-Brain Barrier Dysfunction Induced by Sleep Restriction

(2016) Gabriela Hurtado-Alvarado et al.   PLoS One

Effects of sleep and wake on astrocytes: clues from molecular and ultrastructural studies

(2015) Michele Bellesi et al.   BMC BIOLOGY

Sleep fragmentation and sepsis differentially impact blood–brain barrier integrity and transport of tumor necrosis factor-α in aging

(2015) Mark R. Opp et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells

(2015) Christian Bleau et al.   JOURNAL OF VIROLOGY

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Systemic Inflammation and the Brain: Novel Roles of Genetic, Molecular, and Environmental Cues as Drivers of Neurodegeneration

(2015) Roman Sankowski et al.   Frontiers in Cellular Neuroscience

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

(2015) Norman R. Saunders et al.   Frontiers in Neuroscience

Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain

(2014) Laura Kervezee et al.   AAPS Journal

Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature

(2014) Koryn A. Carver et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sleep Restriction Impairs Blood-Brain Barrier Function

(2014) J. He et al.   JOURNAL OF NEUROSCIENCE

Infra-Slow EEG Fluctuations Are Correlated with Resting-State Network Dynamics in fMRI

(2014) T. Hiltunen et al.   JOURNAL OF NEUROSCIENCE

Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression

(2014) Mark R. Zielinski et al.   NEUROSCIENCE LETTERS

Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men

(2014) Agorastos Agorastos et al.   PSYCHONEUROENDOCRINOLOGY

Alzheimer Disease in a Mouse Model: MR Imaging–guided Focused Ultrasound Targeted to the Hippocampus Opens the Blood-Brain Barrier and Improves Pathologic Abnormalities and Behavior

(2014) Alison Burgess et al.   RADIOLOGY

Acute Sleep Deprivation Increases Serum Levels of Neuron-Specific Enolase (NSE) and S100 Calcium Binding Protein B (S-100B) in Healthy Young Men

(2014) Christian Benedict et al.   SLEEP

Assessment of blood–brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review

(2014) Anna K. Heye et al.   NeuroImage-Clinical

Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells

(2013) Yinghua Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sleep Loss as a Factor to Induce Cellular and Molecular Inflammatory Variations

(2013) Gabriela Hurtado-Alvarado et al.   Clinical & Developmental Immunology

REM Sleep Loss and Recovery Regulates Blood-Brain Barrier Function

(2013) Beatriz Gomez-Gonzalez et al.   CURRENT NEUROVASCULAR RESEARCH

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

(2013) Jessica F. Jordão et al.   EXPERIMENTAL NEUROLOGY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Obstructive sleep apnea and cognitive impairment: Addressing the blood–brain barrier

(2013) Diane C. Lim et al.   SLEEP MEDICINE REVIEWS

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis

(2012) Camila Hirotsu et al.   PLoS One

Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study

(2011) Lobna Ibrahim et al.   BRAIN RESEARCH BULLETIN

Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men

(2011) M. Chennaoui et al.   CYTOKINE

Membrane potential depolarization decreases the stiffness of vascular endothelial cells

(2011) C. Callies et al.   JOURNAL OF CELL SCIENCE

Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo

(2011) N. Takata et al.   JOURNAL OF NEUROSCIENCE

Noradrenaline acting at central β-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: Implications for neurodegeneration

(2010) Eoin N. McNamee et al.   BRAIN BEHAVIOR AND IMMUNITY

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Good night and good luck: Norepinephrine in sleep pharmacology

(2009) Heather A. Mitchell et al.   BIOCHEMICAL PHARMACOLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP

(2009) Wessel M. A. van Leeuwen et al.   PLoS One

Disturbed sleep is associated with increased C-reactive protein in young women

(2008) Michele L. Okun et al.   BRAIN BEHAVIOR AND IMMUNITY

Very Slow EEG Fluctuations Predict the Dynamics of Stimulus Detection and Oscillation Amplitudes in Humans

(2008) S. Monto et al.   JOURNAL OF NEUROSCIENCE