Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link

Sleep Duration and Biomarkers of Inflammation

(2017) Sanjay R. Patel et al.   SLEEP

Glial influences on BBB functions and molecular players in immune cell trafficking

(2016) Marc-André Lécuyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin-Like Growth Factor (IGF)-I Modulates Endothelial Blood-Brain Barrier Function in Ischemic Middle-Aged Female Rats

(2016) Shameena Bake et al.   ENDOCRINOLOGY

The Blood-Brain Barrier

(2016) Weihong Pan et al.   NEUROSCIENTIST

Gut microbiota, obesity and diabetes

(2016) Elaine Patterson et al.   POSTGRADUATE MEDICAL JOURNAL

Psoriasis and sleep disorders: A systematic review

(2016) Madhulika A. Gupta et al.   SLEEP MEDICINE REVIEWS

Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis

(2016) Thunyarat Anothaisintawee et al.   SLEEP MEDICINE REVIEWS

Acute sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone concentration

(2015) Jennifer E. Dumaine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Prolonged REM sleep restriction induces metabolic syndrome-related changes: Mediation by pro-inflammatory cytokines

(2015) Daniel Paulino Venancio et al.   BRAIN BEHAVIOR AND IMMUNITY

Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans

(2015) Michael R. Irwin et al.   BRAIN BEHAVIOR AND IMMUNITY

Impairment of male reproductive function after sleep deprivation

(2015) Tathiana A. Alvarenga et al.   FERTILITY AND STERILITY

Impact of inflammatory markers on the relationship between sleep quality and incident cardiovascular events in type 2 diabetes

(2015) Ling-Ling Meng et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium

(2015) Keith D. Rochfort et al.   MICROVASCULAR RESEARCH

Sleep Deprived and Sweating It Out: The Effects of Total Sleep Deprivation on Skin Conductance Reactivity to Psychosocial Stress

(2015) Jean C.J. Liu et al.   SLEEP

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

(2015) John R. Kelly et al.   Frontiers in Cellular Neuroscience

Neuroprotective effect of interleukin-6 in a rat model of cerebral ischemia

(2015) QILIN FENG et al.   Experimental and Therapeutic Medicine

Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment

(2015) Qiuying Zhao et al.   Scientific Reports

Sleep Deprived and Sweating It Out: The Effects of Total Sleep Deprivation on Skin Conductance Reactivity to Psychosocial Stress

(2015) Jean C.J. Liu et al.   SLEEP

Sleep Deficiency and Deprivation Leading to Cardiovascular Disease

(2015) Michelle Kohansieh et al.   International Journal of Hypertension

Tumor necrosis factor-α disruption of brain endothelial cell barrier is mediated through matrix metalloproteinase-9

(2014) Katie Wiggins-Dohlvik et al.   AMERICAN JOURNAL OF SURGERY

The effect of IGF-1 on symptoms of sleep deprivation in a rat model of inflammatory heart disease and metabolic syndrome

(2014) Haiyan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity

(2014) V M Pak et al.   INTERNATIONAL JOURNAL OF OBESITY

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

(2014) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Sleep Restriction Impairs Blood-Brain Barrier Function

(2014) J. He et al.   JOURNAL OF NEUROSCIENCE

Immune-Induced Fever Is Mediated by IL-6 Receptors on Brain Endothelial Cells Coupled to STAT3-Dependent Induction of Brain Endothelial Prostaglandin Synthesis

(2014) A. Eskilsson et al.   JOURNAL OF NEUROSCIENCE

Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression

(2014) Mark R. Zielinski et al.   NEUROSCIENCE LETTERS

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation

(2014) Junichi Matsumoto et al.   NEUROSCIENCE LETTERS

Late effects of sleep restriction: Potentiating weight gain and insulin resistance arising from a high-fat diet in mice

(2014) Edson Mendes de Oliveira et al.   Obesity

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

(2014) Yue Wang et al.   PLoS One

Total Sleep Deprivation Alters Endothelial Function in Rats: A Nonsympathetic Mechanism

(2014) Fabien Sauvet et al.   SLEEP

Chronic Sleep Fragmentation Induces Endothelial Dysfunction and Structural Vascular Changes in Mice

(2014) Alba Carreras et al.   SLEEP

Sleep, its regulation and possible mechanisms of sleep disturbances

(2013) T. Porkka-Heiskanen et al.   Acta Physiologica

Obstructive Sleep Apnea Syndrome, Vascular Pathology, Endothelial Function and Endothelial Cells and Circulating Microparticles

(2013) Pablo Stiefel et al.   ARCHIVES OF MEDICAL RESEARCH

Effects of Partial Sleep Deprivation on Proinflammatory Cytokines, Growth Hormone, and Steroid Hormone Concentrations During Repeated Brief Sprint Interval Exercise

(2013) Salma Abedelmalek et al.   CHRONOBIOLOGY INTERNATIONAL

Sleep Loss as a Factor to Induce Cellular and Molecular Inflammatory Variations

(2013) Gabriela Hurtado-Alvarado et al.   Clinical & Developmental Immunology

REM Sleep Loss and Recovery Regulates Blood-Brain Barrier Function

(2013) Beatriz Gomez-Gonzalez et al.   CURRENT NEUROVASCULAR RESEARCH

Altered colonic function and microbiota profile in a mouse model of chronic depression

(2013) A. J. Park et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Obstructive sleep apnea and cognitive impairment: Addressing the blood–brain barrier

(2013) Diane C. Lim et al.   SLEEP MEDICINE REVIEWS

Cardiovascular effects of partial sleep deprivation in healthy volunteers

(2012) Josilene L. Dettoni et al.   JOURNAL OF APPLIED PHYSIOLOGY

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

(2012) M. A. Lopez-Ramirez et al.   JOURNAL OF IMMUNOLOGY

Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway

(2012) Vijay Ramesh et al.   Journal of Neuroinflammation

Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study

(2011) Lobna Ibrahim et al.   BRAIN RESEARCH BULLETIN

Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men

(2011) M. Chennaoui et al.   CYTOKINE

Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction

(2011) Jing Peng et al.   Journal of Neuroinflammation

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

The cognitive cost of sleep lost

(2011) John G. McCoy et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The Effects of Th17 Cytokines on the Inflammatory Mediator Production and Barrier Function of ARPE-19 Cells

(2011) Ying Chen et al.   PLoS One

Short sleep duration is associated with enhanced endothelin-1 vasoconstrictor toneThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

(2010) Brian R. Weil et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

CRP-induced levels of oxidative stress are higher in brain than aortic endothelial cells

(2010) Dorothea Closhen et al.   CYTOKINE

Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

(2010) Francieli S Ruiz et al.   Innate Immunity

Transport of interleukin-1 across cerebromicrovascular endothelial cells

(2009) RA Skinner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL

Circadian Disruption, Per3, and Human Cytokine Secretion

(2009) Jaclyn Guess et al.   INTEGRATIVE CANCER THERAPIES

Effect of acute sleep deprivation on vascular function in healthy subjects

(2009) Fabien Sauvet et al.   JOURNAL OF APPLIED PHYSIOLOGY

REM Sleep Deprivation in Rats Results in Inflammation and Interleukin-17 Elevation

(2009) Shlomo Yehuda et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Matrix metalloproteinase-9 deficiency leads to prolonged foreign body response in the brain associated with increased IL-1β levels and leakage of the blood-brain barrier

(2009) Weiming Tian et al.   MATRIX BIOLOGY

Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP

(2009) Wessel M. A. van Leeuwen et al.   PLoS One

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of C-Reactive Protein-Induced Blood–Brain Barrier Disruption

(2009) Christoph R.W. Kuhlmann et al.   STROKE

NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells

(2009) Sung Yong Eum et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Disturbed sleep is associated with increased C-reactive protein in young women

(2008) Michele L. Okun et al.   BRAIN BEHAVIOR AND IMMUNITY

CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis

(2008) J. H. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New neurons in the adult brain: The role of sleep and consequences of sleep loss

(2008) Peter Meerlo et al.   SLEEP MEDICINE REVIEWS

Do all animals sleep?

(2008) Jerome M. Siegel   TRENDS IN NEUROSCIENCES