Review
Geriatrics & Gerontology
Xiangfei Huang, Jun Ying, Danying Yang, Pu Fang, Xifeng Wang, Bin Zhou, Lieliang Zhang, Yang Fang, Wen Yu, Xing Liu, Qingcui Zhen, Fuzhou Hua
Summary: Sevoflurane is commonly used as an inhaled anesthetic due to its properties, but recent studies suggest it may have negative effects on cognitive function. The mechanisms underlying this are not fully understood, but may involve neuroinflammation, blood-brain barrier breakdown, changes in gut microbiota, and cholinergic neurotransmission.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Xiangfei Huang, Jun Ying, Danying Yang, Pu Fang, Xifeng Wang, Bin Zhou, Lieliang Zhang, Yang Fang, Wen Yu, Xing Liu, Qingcui Zhen, Fuzhou Hua
Summary: Sevoflurane, a commonly used inhaled anesthetic, may have detrimental effects on cognitive function. Possible mechanisms include modulation of microglial function, blood-brain barrier breakdown, changes in gut microbiota, and facilitation of cholinergic neurotransmission.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Oncology
Chen Gan, Wen Li, Jian Xu, Lulian Pang, Lingxue Tang, Sheng Yu, Anlong Li, Han Ge, Runze Huang, Huaidong Cheng
Summary: Radiation therapy commonly leads to radiation-induced brain injury, for which there are currently no effective treatments. This review discusses the molecular mechanisms of radiation-induced brain injury and provides future research directions.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Oxana Semyachkina-Glushkovskaya, Alexander Khorovodov, Ivan Fedosov, Alexey Pavlov, Alexander Shirokov, Ali Esmat Sharif, Alexander Dubrovsky, Inna Blokhina, Andrey Terskov, Nikita Navolokin, Arina Evsukova, Georgy Karandin, Dariya Elovenko, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven, Elena Saranceva, Tatyana Iskra, Juergen Kurths
Summary: The lymphatic system in the brain meninges and head is crucial in clearing pathogenic A beta protein related to Alzheimer's disease. Developing methods to modulate this clearance process could be revolutionary in AD therapy. A noninvasive music-induced method of opening the blood-brain barrier to stimulate A beta clearance is proposed, showing promising results in studies using imaging techniques.
APPLIED SCIENCES-BASEL
(2021)
Review
Neurosciences
Melanie E. M. Stamp, Michael Halwes, David Nisbet, David J. Collins
Summary: The blood-brain barrier is a selectively permeable membrane that protects neural tissue from harmful substances but also limits drug delivery to the brain. Physical approaches such as focused ultrasound have shown promise in disrupting the blood-brain barrier temporarily and locally, allowing drugs to enter specific regions of the brain. However, the safety, efficacy, and practicality of these physical approaches for clinical use are still being researched.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Article
Chemistry, Multidisciplinary
Danmin Lin, Zhen Wang, Wei Long, Mingze Xu, Aolu Liu, Yifei Gao, Zhu Wen, Chao Liu, Jiecheng He, Yuxue Cheng, Siyuan Jiang, Jiapeng Chen, Qingpeng Liu, Lingkun Zhang, Rong You, Liang Yin, Yanqing Guan
Summary: In this study, ultrasound combined with microbubbles was used to open the blood-brain barrier, and a nanosonosensitizer was developed by conjugating Poly(I:C) with a sonosensitizer protoporphyrin IX and hyaluronic acid. The nanosonosensitizer could target and penetrate glioblastoma, induce immunogenic cell death, and activate anti-tumor immune responses. In a mouse model, this treatment prolonged survival and increased immune cell infiltration.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Sahar Jafari, Ittai S. Baum, Oleg G. Udalov, Yichien Lee, Olga Rodriguez, Stanley T. Fricke, Maryam Jafari, Mostafa Amini, Roland Probst, Xinyao Tang, Cheng Chen, David J. Ariando, Anjana Hevaganinge, Lamar O. Mair, Christopher Albanese, Irving N. Weinberg
Summary: By tuning magnetic pulses, the blood brain barrier can be safely and effectively opened to enhance drug transport. This method can be applied in the treatment of various brain disorders.
Article
Engineering, Biomedical
Maria Eleni Karakatsani, Antonios N. Pouliopoulos, Michael Liu, Sachin R. Jambawalikar, Elisa E. Konofagou
Summary: The study investigated the use of diffusion tensor imaging for detecting focused ultrasound-induced blood-brain barrier opening, showing an increase in fractional anisotropy and diffusion anisotropy enhancement post-BBB opening. The experiment confirmed the feasibility of the technique and suggested its potential as a contrast-free MRI modality for evaluating BBB integrity in brain-related pathologies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Neurosciences
Shanshan Zhang, Lin Gan, Fengye Cao, Hao Wang, Peng Gong, Congcong Ma, Li Ren, Yubo Lin, Xianming Lin
Summary: This review provides an overview of the three barriers formed between the cerebrovascular and the brain parenchyma, focusing on the composition and function of the blood-brain barrier (BBB). It discusses the limitations of the BBB for drug delivery and explores potential strategies for improving CNS drug delivery.
BRAIN RESEARCH BULLETIN
(2022)
Article
Multidisciplinary Sciences
Carmen Gasca-Salas, Beatriz Fernandez-Rodriguez, Jose A. Pineda-Pardo, Rafael Rodriguez-Rojas, Ignacio Obeso, Frida Hernandez-Fernandez, Marta del Alamo, David Mata, Pasqualina Guida, Carlos Ordas-Bandera, J. Ignacio Montero-Roblas, Raul Martinez-Fernandez, Guglielmo Foffani, Itay Rachmilevitch, Jose A. Obeso
Summary: MRgFUS-BBB opening in PDD is safe, reversible, and can be performed repeatedly. This study provides encouragement for the concept of BBB opening for drug delivery to treat dementia in PD and other neurodegenerative disorders.
NATURE COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Yiran Yan, Yan Chen, Zhongxun Liu, Feiyan Cai, Wanting Niu, Liming Song, Haifeng Liang, Zhiwen Su, Bo Yu, Fei Yan
Summary: This study improved the solubility of curcumin and developed Cur-NBs for brain delivery of curcumin against PD by combining with LIFU-mediated BBB opening. Cur-NBs serve as a platform for potential drugs that have difficulty crossing the BBB to treat PD and other CNS diseases.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Physical
Mi Zhou, Tong Wei, Lingzhi Gu, Hong Yang, Ming Li, Yang Zhou
Summary: This study investigated the focal opening of a realistically human brain plasma membrane (PM) model by the jet from cavitation, and analyzed the influence of membrane components, particle velocity, and bubble diameters on the opening size. The study found that the size of the jet determines the pore size, not the impulse. The recovery simulation showed that membranes with smaller pores recovered quickly, while those with larger pores took longer to recover.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Barrett D. Allen, Charles L. Limoli
Summary: Exposure to radiation during the treatment of CNS tumors leads to detrimental damage of the blood brain barrier (BBB) in normal tissue, while the irregular vasculature of the blood tumor barrier (BTB) causes tumor tissue to become resistant to radiation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Feng Fan, Meng Lei
Summary: Ischemic stroke is a major cause of death and disability worldwide, and restoring blood flow to ischemic brain tissues is the main therapeutic strategy. However, reperfusion after ischemia leads to pathological mechanisms that worsen brain tissue injury. Curcumin has been shown to have neuroprotective effects in cerebral ischemia through various mechanisms, such as antioxidation, anti-inflammation, anti-apoptosis, protection of the blood-brain barrier, and restoration of mitochondrial function and structure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhuqing Song, Xiuxian Huang, Jieqiong Wang, Feiyan Cai, Ping Zhao, Fei Yan
Summary: The ultrasound-mediated BBB opening combined with liposomal temozolomide formulation has been successfully applied in the treatment of glioblastoma, significantly inhibiting tumor growth and prolonging animal survival time without significant side effects.
Article
Biochemical Research Methods
Luis R. Oliveira, Ricardo M. Ferreira, Maria R. Pinheiro, Hugo F. Silva, Valery V. Tuchin, Luis M. Oliveira
Summary: Sequential optical immersion clearing treatments can increase tissue transparency and have high interest for clinical applications. This study found that a saline immersion can reverse the clearing effect in lung tissue, while a second treatment with the optical clearing agent can double the transparency, indicating a conversion of bound water to mobile water during the first treatment.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Biochemical Research Methods
Hugo F. Silva, Ines S. Martins, Alexei A. Bogdanov, Valery V. Tuchin, Luis M. Oliveira
Summary: The recent increase in interest in the application of radiology contrasting agents to create transparency in biological tissues has led to the need for evaluating the diffusion properties of these agents. This study evaluated and compared the diffusion properties of gadobutrol and glycerol in skeletal muscle, showing that gadobutrol has a faster diffusion in the muscle despite its higher molar mass.
JOURNAL OF BIOPHOTONICS
(2023)
Editorial Material
Biochemical Research Methods
Luis M. Oliveira, Igor Meglinski, Valery V. Tuchin
JOURNAL OF BIOPHOTONICS
(2023)
Article
Pharmacology & Pharmacy
Oxana Semyachkina-Glushkovskaya, Alexander Shirokov, Inna Blokhina, Valeria Telnova, Elena Vodovozova, Anna Alekseeva, Ivan Boldyrev, Ivan Fedosov, Alexander Dubrovsky, Alexandr Khorovodov, Andrey Terskov, Arina Evsukova, Daria Elovenko, Viktoria Adushkina, Maria Tzoy, Ilana Agranovich, Jurgen Kurths, Edik Rafailov
Summary: The blood-brain barrier poses a challenge in delivering cancer drugs to the brain for effective brain tumor treatment. The nasal-brain-lymphatic system is considered as a potential pathway to overcome this barrier. However, the distance for drug delivery is often too short to achieve a therapeutic effect. Therefore, it is crucial to develop technologies to enhance the nose-to-brain delivery of pharmaceuticals. This study demonstrates the successful delivery of liposomes to the mouse brain, specifically reaching glioblastoma, through intranasal delivery. The role of the meningeal pathway in this delivery route is highlighted, and near-infrared photostimulation of the lymphatic vessels is shown to improve the delivery efficiency. These findings suggest the potential of using nanocarriers and near-infrared laser-based therapeutic devices for non-invasive and enhanced intranasal delivery of cancer drugs to the brain tissues.
Article
Pharmacology & Pharmacy
Oxana Semyachkina-Glushkovskaya, Denis Bragin, Olga Bragina, Sergey Socolovski, Alexander Shirokov, Ivan Fedosov, Vasily Ageev, Inna Blokhina, Alexander Dubrovsky, Valeria Telnova, Andrey Terskov, Alexander Khorovodov, Daria Elovenko, Arina Evsukova, Maria Zhoy, Ilana Agranovich, Elena Vodovozova, Anna Alekseeva, Juergen Kurths, Edik Rafailov
Summary: Low-level laser treatment (LLLT) can open the blood-brain barrier (BBB) and improve drug delivery to the brain, which is significant for the treatment of brain diseases.
Editorial Material
Engineering, Electrical & Electronic
Qiyin Fang, Charles Kervrann, David Nolte, Oxana Semyachkina-Glushkovskaya, Shuo Tang, Yuji Matsuura, Zachary Smith
Summary: Biophotonics is an interdisciplinary field that combines photonics and biomedical applications. It has made significant advancements in clinical diagnosis, therapeutics, biotechnology, and environmental studies. The integration of optics and biology has led to quick adoption of photonics technologies in medicine due to its compatibility with minimally invasive procedures.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Jiawei Song, Nan Zeng, Hui Ma, Valery V. Tuchin
Summary: This study proposes a non-invasive polarization optical method to evaluate the microstructural changes in tissues during agent diffusion. The method is validated through experiments using skeletal muscle samples and Monte Carlo simulations. It provides a quantitative characterization of tissue changes and offers insights into the optical clearing stages in tissues.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Alexey Selifonov, Ekaterina Selifonova, Valery V. V. Tuchin
Summary: The study used diffuse reflectance spectroscopy to investigate the changes in the optical properties of gingival mucosa caused by e-liquids in the range of 200-800 nm. It revealed the presence of three dynamic windows of gingival optical transparency in the ultraviolet (UV) range. The diffusion coefficients of e-liquids with different compositions in the gingival mucosa were estimated, which is of practical importance in disease prevention, pharmaceutical toxicity associated with vaping, and improving the effectiveness of oral UV therapy.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Maria Rosario Pinheiro, Valery V. V. Tuchin, Luis Manuel Oliveira
Summary: This article explores the use of diffuse reflectance (R-d) spectroscopy to evaluate water and sucrose diffusion properties in skeletal muscle during optical clearing treatments. By treating muscle samples with sucrose-water solutions of different osmolarities, collimated transmittance (T-c) and R-d measurements were performed to obtain diffusion time (t) and diffusion coefficient (D) values. The results show that the estimated t and D values for water in the muscle are 63.1s and 1.72x10(-6) cm(2)/s, while for sucrose they are 261s and 4.86x10(-7) cm(2)/s. Comparing these values with the ones estimated from T-c measurements, the relative differences for t and D are 1.6% and 2.8% for water, and 0.3% and 0.4% for sucrose.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Viktor Dremin, Oxana Semyachkina-Glushkovskaya, Edik Rafailov
Summary: In recent years, there has been a growing interest in the role of singlet oxygen as a regulator of cellular functions. The use of photosensitisers is a common method to generate singlet oxygen by exciting the triplet form of oxygen. However, recent studies have shown the possibility of directly exciting the main form of oxygen into its singlet state using specific wavelengths of light. This review article focuses on the application of a 1267 nm wavelength for the direct optical generation of singlet oxygen. It discusses the biomedical applications of laser-induced singlet oxygen at both cellular and organism levels, including its therapeutic effects on cancer cells and its stimulation of neurons, as well as the vascular and lymphatic systems.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Oxana Semyachkina-Glushkovskaya, Sergey Sokolovski, Ivan Fedosov, Alexander Shirokov, Nikita Navolokin, Alla Bucharskaya, Inna Blokhina, Andrey Terskov, Alexander Dubrovski, Valeria Telnova, Anna Tzven, Maria Tzoy, Arina Evsukova, Daria Zhlatogosrkaya, Viktoria Adushkina, Alexander Dmitrenko, Maria Manzhaeva, Valeria Krupnova, Alessio Noghero, Denis Bragin, Olga Bragina, Ekaterina Borisova, Juergen Kurths, Edik Rafailov
Summary: This study demonstrates the efficacy of photosensitizer-free laser treatment using a quantum-dot-based 1267 nm laser diode in suppressing the growth of glioblastoma (GBM) in rats. The findings suggest that this technology has the potential to be a breakthrough in non-invasive or minimally invasive therapy for superficial GBMs, particularly in infants and patients with high photosensitivity or allergies to photosensitizers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Ali Jaafar, Abbas Albarazanchi, Mohammed Jawad Kadhim, Maxim E. Darvin, Tamas Vaczi, Valery V. Tuchin, Miklos Veres
Summary: The influence of e-liquid on porcine lung immersed in it was investigated using confocal Raman micro-spectroscopy. The results showed that the Raman band intensities related to the lung increased after treatment, except for the surface, which was due to the optical clearing effect caused by alveoli filling with e-liquid. Additionally, oxidative stress and collagen dehydration induced by e-liquid were observed. These findings suggest that nicotine-flavour-free e-liquids could potentially be used as optical clearing agents for enhanced Raman-guided bronchoscopy.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Biochemical Research Methods
Yimeng Wang, Da Huang, Kaiqiang Shu, Yingtong Xu, Yixiang Duan, Qingwen Fan, Qingyu Lin, Valery V. Tuchin
Summary: In this study, an innovative method based on laser-induced breakdown spectroscopy (LIBS) combined with machine learning was developed to distinguish and classify different tumor cell lines. Convolutional neural network (CNN) and support vector machine (SVM) algorithms achieved impressive discrimination performances for tumor cell distinguishing, with an accuracy of 97.72%. The results demonstrate the important role of element heterogeneity in tumor cell distinction and suggest the potential application of LIBS technique for fast classification of tumor cells.
JOURNAL OF BIOPHOTONICS
(2023)
Correction
Biochemistry & Molecular Biology
Roman Verkhovskii, Alexey Ermakov, Oleg Grishin, Mikhail A. Makarkin, Ilya Kozhevnikov, Mikhail Makhortov, Anastasiia Kozlova, Samia Salem, Valery Tuchin, Daniil Bratashov
Article
Physics, Applied
A. S. Kucheryavenko, I. N. Dolganova, A. A. Zhokhov, V. M. Masalov, G. R. Musina, V. V. Tuchin, N. V. Chernomyrdin, A. A. Gavdush, D. R. Il'enkova, S. V. Garnov, K. I. Zaytsev
Summary: In this paper, the researchers studied the use of Terahertz (THz) technology in medical spectroscopy and imaging. They found that tissues can have inhomogeneities at the THz wavelength scale, leading to scattering effects. To address this challenge, they developed a tissue-mimicking phantom and found that the effective optical properties can still be described using the effective medium theory (EMT).
PHYSICAL REVIEW APPLIED
(2023)