Article
Endocrinology & Metabolism
Kakali Ghoshal, Xiyue Li, Dungeng Peng, John R. Falck, Raghunath Reddy Anugu, Manuel Chiusa, John M. Stafford, David H. Wasserman, Roy Zent, James M. Luther, Ambra Pozzi
Summary: In this study, researchers found that the administration of a water-soluble EET analog can improve insulin signaling in a genetic model of hepatic insulin resistance. The EET analog enhances hepatic insulin signaling, decreases expression of gluconeogenic genes, and increases expression of glycogenic genes. Mechanistically, the EET analog stabilizes membrane-associated IR beta and potentiates insulin signaling.
Review
Biochemistry & Molecular Biology
Zeqi Shi, Zuowen He, Dao Wen Wang
Summary: Inflammation plays a crucial role in various systemic illnesses, and EETs have been found to have anti-inflammatory effects, reducing inflammation and remodeling of blood vessels. EETs also play important roles in other pathological conditions. Manipulating the AA-CYP450-EETs-sEH pathway has shown potential in alleviating inflammatory diseases, highlighting the importance of this research field.
Article
Neurosciences
Hope Needham, Grace Torpey, Carlos C. Flores, Christopher J. Davis, William M. Vanderheyden, Jason R. Gerstner
Summary: Fatty acid binding protein 7 (FABP7) plays a crucial role in regulating wakefulness and sleep, inflammation, and neuroprotection through its interaction with different fatty acids.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Celia A. McKee, Alexander J. Polino, Melvin W. King, Erik S. Musiek
Summary: The circadian clock is found to play a new role in autophagy and lysosome function, suggesting new directions for studying neurodegeneration. Circadian clock proteins coordinate gene expression programs involved in daily rhythms and cellular processes. The depletion of the core clock protein BMAL1 in astrocytes disrupts circadian function and leads to a unique cell-autonomous activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Rodolfo Costa, Sara Montagnese
Summary: Evidence suggests that the mammalian circadian clock system is more complex than previously believed, with astrocytic cells playing a significant role in generating the oscillation. The astrocytic clock may also contribute to circadian and seasonal rhythmicity in health and neurodegenerative disorders. Additionally, the role of the astrocytic clock in determining clinical features of hepatic encephalopathy warrants further investigation.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Pedro Felipe Malacarne, Justus Bezzenberger, Melina Lopez, Timothy Warwick, Niklas Mueller, Ralf P. Brandes, Flavia Rezende
Summary: In this study, it was found that there is crosstalk between EETs and prostaglandins in the vascular system, and the lack of EET production sensitizes vessels to vasoconstriction. These findings have important implications for understanding vascular function and the development of related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Justin S. Kim, Andres S. Arango, Swapnil Shah, William R. Arnold, Emad Tajkhorshid, Aditi Das
Summary: By using experimental and theoretical methods, this study unveils the interactions between anthracycline derivatives and CYP2J2, which helps to understand the potential mechanism of anthracycline cardiotoxicity and aids in the design of new anthracycline derivatives with lower toxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Immunology
Huiru Xue, Minghui Wu, Yongle Wang, Yunfei Zhao, Meini Zhang, Hui Zhang
Summary: This study aims to explore the role and molecular basis of circadian rhythms in Neuromyelitis Optica (NMO). The findings indicate that Bmal1 and Clock, essential components of the circadian clock, are significantly decreased in NMO astrocytes. Furthermore, it is suggested that the Cx43-glutamate signaling may be a critical mechanism contributing to the NMO-induced rhythmic damage in astrocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Selina T. Somani, Maxwell Zeigler, Emily E. Fay, Maggie Leahy, Bethanee Bermudez, Rheem A. Totah, Mary F. Hebert
Summary: The study found that changes in arachidonic acid metabolites during pregnancy may be associated with the cytochrome P450 pathway, which plays an important role in healthy pregnancy.
Letter
Medicine, General & Internal
Petr Kala, Tomas Hnat, Karolina Padrova, Karel Kotaska, Josef Veselka
Summary: This study investigated the levels of plasma eicosanoids (14,15-EET and 14,15-DHET) in patients with heart failure (HF) compared to age- and sex-matched controls. The results showed that both eicosanoids were significantly higher in the HF group. These findings suggest elevated peripheral plasma eicosanoid levels in patients with HF.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Thomas Duflot, Charlotte Laurent, Anne Soudey, Xavier Fonrose, Mouad Hamzaoui, Michele Iacob, Dominique Bertrand, Julie Favre, Isabelle Etienne, Clothilde Roche, David Coquerel, Maelle Le Besnerais, Safa Louhichi, Tracy Tarlet, Dongyang Li, Valery Brunel, Christophe Morisseau, Vincent Richard, Robinson Joannides, Francoise Stanke-Labesque, Fabien Lamoureux, Dominique Guerrot, Jeremy Bellien
Summary: This study explored the role of EETs in renal allograft function and cardiovascular modulation. Specific SNPs in the sEH gene were found to impact EET levels and renal function, while CYP450 SNPs had varying effects on vascular and endothelial function. Inhibition of sEH showed promising therapeutic potential in preventing allograft dysfunction and cardiovascular disease in kidney transplant recipients.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
John D. Imig, Md Abdul Hye Khan, Anna Burkhan, Guan Chen, Adeniyi Michael Adebesin, John R. Falck
Summary: The study demonstrated the effective targeted delivery of EET analogs to the kidney, reducing the required drug dosage and potential side effects. EET-F01 showed comparable effectiveness to EET-A in decreasing cisplatin nephrotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Siyu Lai, Dandan Yan, Jie Xu, Xiangtian Yu, Jingyi Guo, Xiangnan Fang, Mengyang Tang, Rong Zhang, Hong Zhang, Weiping Jia, Mingjuan Luo, Cheng Hu
Summary: In this study, the genetic effects of four key genes (CYP2C8, CYP2C9, CYP2J2, and EPHX2) on the processing and degradation pathways of epoxyeicosatrienoic acid in gestational diabetes mellitus (GDM) and metabolic traits were explored in a Chinese population. Significant associations were found between GDM susceptibility and 12 single nucleotide polymorphisms (SNPs) of these genes. A genetic risk score model was constructed to assess GDM risk. Additionally, a significant interaction between CYP2J2 and CYP2C8 in GDM was observed. These findings are important for understanding the genetic mechanisms underlying GDM and predicting GDM risk.
Review
Neurosciences
Francesca Fagiani, Eva Baronchelli, Anna Pittaluga, Edoardo Pedrini, Chiara Scacchi, Stefano Govoni, Cristina Lanni
Summary: The circadian molecular machinery serves as a precise timekeeper to synchronize physiological and behavioral processes with the external environment. This review focuses on the molecular mechanisms regulated by the circadian clock in different brain areas and cells within the central nervous system. Neurons, astrocytes, and microglia all play active roles in maintaining timekeeping within the brain, and neurotransmitters finely tune the diffusion of circadian information among these cells, impacting the core clock machinery.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Yuxing Zhang, Xin Zhao, Ying Zhang, Fukang Zeng, Siyang Yan, Yao Chen, Zhong Li, Desheng Zhou, Lijuan Liu
Summary: Accumulating evidence suggests that astrocytes play a critical role in cerebral infarction, and the circadian clock influences the pathophysiology of astrocytes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Sarah M. Neuner, Lynda A. Wilmott, Kevin A. Hope, Brian Hoffmann, Jayhong A. Chong, Joel Abramowitz, Lutz Birnbaumer, Kristen M. O'Connell, Andrew K. Tryba, Andrew S. Greene, C. Savio Chan, Catherine C. Kaczorowski
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Mathematical & Computational Biology
Hil G. E. Meijer, Tahra L. Eissa, Bert Kiewiet, Jeremy F. Neuman, Catherine A. Schevon, Ronald G. Emerson, Robert R. Goodman, Guy M. McKhann, Charles J. Marcuccilli, Andrew K. Tryba, Jack D. Cowan, Stephan A. van Gils, Wim van Drongelen
JOURNAL OF MATHEMATICAL NEUROSCIENCE
(2015)
Article
Neurosciences
Jyothsna Suresh, Mihailo Radojicic, Lorenzo L. Pesce, Anita Bhansali, Janice Wang, Andrew K. Tryba, Jeremy D. Marks, Wim van Drongelen
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Neurosciences
A. R. Graves, S. J. Moore, N. Spruston, A. K. Tryba, C. C. Kaczorowski
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Neurosciences
Marc Chevalier, Faiza Ben-Mabrouk, Andrew K. Tryba
EUROPEAN JOURNAL OF NEUROSCIENCE
(2008)
Article
Neurosciences
Andrew K. Tryba, Catherine C. Kaczorowski, Faiza Ben-Mabrouk, Frank P. Elsen, Sean M. Lew, Charles J. Marcuccilli
EUROPEAN JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Faiza Ben-Mabrouk, Louella B. Amos, Andrew K. Tryba
EUROPEAN JOURNAL OF NEUROSCIENCE
(2012)
Review
Clinical Neurology
Charles J. Marcuccilli, Andrew K. Tryba, Wim van Drongelen, Henner Koch, Jean Charles Viemari, Fernando Pena-Ortega, Erin L. Doren, Peter Pytel, Marc Chevalier, Ana Mrejeru, Michael H. Kohrman, Robert E. Lasky, Sean M. Lew, David M. Frim, Jan-Marino Ramirez
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2010)
Article
Neurosciences
Andrew K. Tryba, Fernando Pena, Steven P. Lieske, Jean-Charles Viemari, Muriel Thoby-Brisson, Jan-Marino Ramirez
JOURNAL OF NEUROPHYSIOLOGY
(2008)
Correction
Behavioral Sciences
Sarah M. Neuner, Lynda A. Wilmott, Kevin A. Hope, Brian Hoffmann, Jayhong A. Chong, Joel Abramowitz, Lutz Birnbaumer, Kristen O'Connell, Andrew K. Tryba, Andrew S. Greene, C. Savio Chan, Catherine C. Kaczorowski
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Neurosciences
Tahra L. Eissa, Andrew K. Tryba, Charles J. Marcuccilli, Faiza Ben-Mabrouk, Elliot H. Smith, Sean M. Lew, Robert R. Goodman, Guy M. McKhann, David M. Frim, Lorenzo L. Pesce, Michael H. Kohrman, Ronald G. Emerson, Catherine A. Schevon, Wim van Drongelen
Article
Neurosciences
AK Tryba, F Peña, JM Ramirez
JOURNAL OF NEUROSCIENCE
(2006)
Article
Neurosciences
JC Viemari, JC Roux, AK Tryba, R Saywell, H Burnet, F Peña, S Zanella, M Bévengut, M Barthelemy-Requin, LBK Herzing, A Moncla, J Mancini, JM Ramirez, L Villard, G Hilaire
JOURNAL OF NEUROSCIENCE
(2005)
Review
Neurosciences
JM Ramirez, AK Tryba, F Peña
CURRENT OPINION IN NEUROBIOLOGY
(2004)