Aurora B Tension Sensing Mechanisms in the Kinetochore Ensure Accurate Chromosome Segregation

Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation

(2021) Kazuhiko S.K. Uchida et al.   CURRENT BIOLOGY

Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic

(2021) Ana C. Henriques et al.   Scientific Reports

Chiasmata and the kinetochore component Dam1 are crucial for elimination of erroneous chromosome attachments and centromere oscillation at meiosis I

(2021) Misuzu Wakiya et al.   Open Biology

Shake It Off: The Elimination of Erroneous Kinetochore-Microtubule Attachments and Chromosome Oscillation

(2021) Ayumu Yamamoto   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chromosome oscillation promotes Aurora A–dependent Hec1 phosphorylation and mitotic fidelity

(2021) Kenji Iemura et al.   JOURNAL OF CELL BIOLOGY

Tension promotes kinetochore–microtubule release by Aurora B kinase

(2021) Geng-Yuan Chen et al.   JOURNAL OF CELL BIOLOGY

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells

(2020) Amanda J. Broad et al.   JOURNAL OF CELL BIOLOGY

Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis

(2020) Michael A. Hadders et al.   JOURNAL OF CELL BIOLOGY

Leaving no-one behind: how CENP-E facilitates chromosome alignment

(2020) Benjamin Craske et al.   Essays in Biochemistry

The right place at the right time: Aurora B kinase localization to centromeres and kinetochores

(2020) Amanda J. Broad et al.   Essays in Biochemistry

Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors

(2020) Emanuele Roscioli et al.   Cell Reports

Effects of malleable kinetochore morphology on measurements of intrakinetochore tension

(2020) Fioranna Renda et al.   Open Biology

SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres

(2020) Yuichiro Asai et al.   Scientific Reports

The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway

(2019) Prasad Trivedi et al.   Nature Communications

A Gradient in Metaphase Tension Leads to a Scaled Cellular Response in Mitosis

(2019) Soumya Mukherjee et al.   DEVELOPMENTAL CELL

A tension-independent mechanism reduces Aurora B-mediated phosphorylation upon microtubule capture by CENP-E at the kinetochore

(2019) Carmen Taveras et al.   CELL CYCLE

Aurora B-INCENP Localization at Centromeres/Inner Kinetochores Is Required for Chromosome Bi-orientation in Budding Yeast

(2019) Luis J. García-Rodríguez et al.   CURRENT BIOLOGY

The regulation of chromosome segregation via centromere loops

(2019) Josh Lawrimore et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner

(2019) Jonathan Kuhn et al.   JOURNAL OF CELL BIOLOGY

Borealin–nucleosome interaction secures chromosome association of the chromosomal passenger complex

(2019) Maria A. Abad et al.   JOURNAL OF CELL BIOLOGY

Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere

(2019) Yuichiro Asai et al.   JOURNAL OF CELL BIOLOGY

Enrichment of Aurora B kinase at the inner kinetochore controls outer kinetochore assembly

(2019) Mary Kate Bonner et al.   JOURNAL OF CELL BIOLOGY

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

Autophosphorylation is sufficient to release Mps1 kinase from native kinetochores

(2019) Lori B. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

(2019) Olga Afonso et al.   eLife

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation

(2019) Babhrubahan Roy et al.   JOURNAL OF CELL BIOLOGY

Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation

(2019) Cai Liang et al.   JOURNAL OF CELL BIOLOGY

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Tension-Induced Error Correction and Not Kinetochore Attachment Status Activates the SAC in an Aurora-B/C-Dependent Manner in Oocytes

(2018) Antoine Vallot et al.   CURRENT BIOLOGY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments

(2018) Damian Dudka et al.   Nature Communications

Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue

(2018) Grégory Eot-Houllier et al.   Nature Communications

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

(2018) Samuel F. Bakhoum et al.   CELL

The functional diversity of Aurora kinases: a comprehensive review

(2018) Estelle Willems et al.   Cell Division

The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation

(2018) Toni McHugh et al.   JOURNAL OF CELL SCIENCE

Dual recognition of chromatin and microtubules by INCENP is important for mitotic progression

(2017) Michael S. Wheelock et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis

(2017) Xing Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

(2017) Rutger C. C. Hengeveld et al.   Nature Communications

Attachment issues: kinetochore transformations and spindle checkpoint silencing

(2016) Banafsheh Etemad et al.   CURRENT OPINION IN CELL BIOLOGY

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

How the kinetochore couples microtubule force and centromere stretch to move chromosomes

(2016) Aussie Suzuki et al.   NATURE CELL BIOLOGY

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

(2016) Midori Shimada et al.   Nature Communications

Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis

(2016) Mark D. Gurden et al.   Oncotarget

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis

(2015) Kumiko Samejima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minimal model for collective kinetochore–microtubule dynamics

(2015) Edward J. Banigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stable kinetochore–microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells

(2015) Eric C. Tauchman et al.   Nature Communications

Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

(2015) Banafsheh Etemad et al.   Nature Communications

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

(2015) Christian F. Nielsen et al.   Nature Communications

Shugoshin-1 Balances Aurora B Kinase Activity via PP2A to Promote Chromosome Bi-orientation

(2015) Amanda Meppelink et al.   Cell Reports

Inferring the Forces Controlling Metaphase Kinetochore Oscillations by Reverse Engineering System Dynamics

(2015) Jonathan W. Armond et al.   PLoS Computational Biology

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

Chk2 prevents mitotic exit when the majority of kinetochores are unattached

(2014) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

Accurate phosphoregulation of kinetochore–microtubule affinity requires unconstrained molecular interactions

(2014) Anatoly V. Zaytsev et al.   JOURNAL OF CELL BIOLOGY

Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis

(2014) H. D. Eshleman et al.   JOURNAL OF CELL SCIENCE

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

(2014) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

Chromosomal attachments set length and microtubule number in the Saccharomyces cerevisiae mitotic spindle

(2014) Natalie J. Nannas et al.   MOLECULAR BIOLOGY OF THE CELL

A PP1–PP2A phosphatase relay controls mitotic progression

(2014) Agnes Grallert et al.   NATURE

Catch and release: how do kinetochores hook the right microtubules during mitosis?

(2014) Krishna K. Sarangapani et al.   TRENDS IN GENETICS

Individual pericentromeres display coordinated motion and stretching in the yeast spindle

(2013) Andrew D. Stephens et al.   JOURNAL OF CELL BIOLOGY

KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity

(2013) Gina V. Caldas et al.   JOURNAL OF CELL BIOLOGY

Tension sensing by Aurora B kinase is independent of survivin-based centromere localization

(2013) Christopher S. Campbell et al.   NATURE

The signaling network that silences the spindle assembly checkpoint upon the establishment of chromosome bipolar attachment

(2013) F. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A stochastic model of kinetochore–microtubule attachment accurately describes fission yeast chromosome segregation

(2012) Guillaume Gay et al.   JOURNAL OF CELL BIOLOGY

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Ndc80 kinetochore complex directly modulates microtubule dynamics

(2012) N. T. Umbreit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deformations Within Moving Kinetochores Reveal Different Sites of Active and Passive Force Generation

(2012) S. Dumont et al.   SCIENCE

Feedback Control in Sensing Chromosome Biorientation by the Aurora B Kinase

(2011) Kevan J. Salimian et al.   CURRENT BIOLOGY

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC–spindle interaction to ensure proper microtubule dynamics

(2011) Yuko Nakajima et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation at serine 331 is required for Aurora B activation

(2011) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient

(2011) Enxiu Wang et al.   JOURNAL OF CELL BIOLOGY

Cohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring

(2011) Andrew D. Stephens et al.   JOURNAL OF CELL BIOLOGY

Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis

(2011) K. F. DeLuca et al.   JOURNAL OF CELL SCIENCE

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Examining the dynamics of chromosomal passenger complex (CPC)-dependent phosphorylation during cell division

(2011) L. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex

(2011) A. Arockia Jeyaprakash et al.   STRUCTURE

Contrasting models for kinetochore microtubule attachment in mammalian cells

(2010) Bruce F. McEwen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Tension directly stabilizes reconstituted kinetochore-microtubule attachments

(2010) Bungo Akiyoshi et al.   NATURE

Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

(2010) Alexander E. Kelly et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Sensing centromere tension: Aurora B and the regulation of kinetochore function

(2010) Michael A. Lampson et al.   TRENDS IN CELL BIOLOGY

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Kinetochore stretching inactivates the spindle assembly checkpoint

(2009) Kazuhiko S.K. Uchida et al.   JOURNAL OF CELL BIOLOGY

Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity

(2009) Thomas J. Maresca et al.   JOURNAL OF CELL BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Biophysics of Catch Bonds

(2008) Wendy E. Thomas et al.   Annual Review of Biophysics

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

Bi-orienting chromosomes: acrobatics on the mitotic spindle

(2008) Tomoyuki U. Tanaka   CHROMOSOMA

Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres

(2008) Leena J. Ahonen et al.   CHROMOSOMA

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

(2008) Zuojun Yue et al.   JOURNAL OF CELL BIOLOGY

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

(2008) Brian G. Fuller et al.   NATURE

The cohesin ring concatenates sister DNA molecules

(2008) Christian H. Haering et al.   NATURE