Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells

(2020) Amanda J. Broad et al.   JOURNAL OF CELL BIOLOGY

The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway

(2019) Prasad Trivedi et al.   Nature Communications

Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

(2019) Gang Zhang et al.   EMBO JOURNAL

Aurora B-INCENP Localization at Centromeres/Inner Kinetochores Is Required for Chromosome Bi-orientation in Budding Yeast

(2019) Luis J. García-Rodríguez et al.   CURRENT BIOLOGY

The COMA complex interacts with Cse4 and positions Sli15/Ipl1 at the budding yeast inner kinetochore

(2019) Josef Fischböck-Halwachs et al.   eLife

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised

(2018) Jonne A. Raaijmakers et al.   Cell Reports

Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

(2018) Tae Yeon Yoo et al.   eLife

Chromosome instability in tumor cells due to defects in Aurora B mediated error correction at kinetochores

(2018) Haomin Huang et al.   CELL CYCLE

Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion

(2018) Jose-Antonio Rodriguez-Rodriguez et al.   CURRENT BIOLOGY

The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation

(2018) Toni McHugh et al.   JOURNAL OF CELL SCIENCE

Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

(2017) Rutger C. C. Hengeveld et al.   Nature Communications

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

(2017) Sanne Hindriksen et al.   PLoS One

Bub1 targeting to centromeres is sufficient for Sgo1 recruitment in the absence of kinetochores

(2016) Samantha J. Williams et al.   CHROMOSOMA

A Centromere-Signaling Network Underlies the Coordination among Mitotic Events

(2016) Prasad Trivedi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bistability of a coupled Aurora B kinase-phosphatase system in cell division

(2016) Anatoly V Zaytsev et al.   eLife

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

(2016) Anna P Baron et al.   eLife

Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores

(2015) Soonjoung Kim et al.   JOURNAL OF CELL BIOLOGY

Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation

(2015) Hong Liu et al.   MOLECULAR CELL

Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores

(2015) Michael E. Bekier et al.   Nature Communications

Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules

(2015) Armando van der Horst et al.   Cell Reports

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

(2015) Katharina Overlack et al.   eLife

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

Cell division: control of the chromosomal passenger complex in time and space

(2013) Armando van der Horst et al.   CHROMOSOMA

Phospho-H2A and Cohesin Specify Distinct Tension-Regulated Sgo1 Pools at Kinetochores and Inner Centromeres

(2013) Hong Liu et al.   CURRENT BIOLOGY

KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity

(2013) Gina V. Caldas et al.   JOURNAL OF CELL BIOLOGY

Tension sensing by Aurora B kinase is independent of survivin-based centromere localization

(2013) Christopher S. Campbell et al.   NATURE

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

(2013) Ivana Primorac et al.   eLife

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

(2012) Lindsey A. Shepperd et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

Mps1 promotes rapid centromere accumulation of Aurora B

(2012) Maike S van der Waal et al.   EMBO REPORTS

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

(2012) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation

(2012) Fangwei Wang et al.   JOURNAL OF CELL BIOLOGY

Structural analysis reveals features of the spindle checkpoint kinase Bub1–kinetochore subunit Knl1 interaction

(2012) Veronica Krenn et al.   JOURNAL OF CELL BIOLOGY

A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

(2012) Anna De Antoni et al.   JOURNAL OF CELL BIOLOGY

Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres

(2012) Ewa Niedzialkowska et al.   MOLECULAR BIOLOGY OF THE CELL

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin

(2012) Jiamu Du et al.   STRUCTURE

KNL1/Spc105 Recruits PP1 to Silence the Spindle Assembly Checkpoint

(2011) Jessica S. Rosenberg et al.   CURRENT BIOLOGY

Spindle Checkpoint Silencing Requires Association of PP1 to Both Spc7 and Kinesin-8 Motors

(2011) John C. Meadows et al.   DEVELOPMENTAL CELL

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient

(2011) Enxiu Wang et al.   JOURNAL OF CELL BIOLOGY

Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis

(2011) K. F. DeLuca et al.   JOURNAL OF CELL SCIENCE

Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex

(2011) A. Arockia Jeyaprakash et al.   STRUCTURE

MultiBac: expanding the research toolbox for multiprotein complexes

(2011) Christoph Bieniossek et al.   TRENDS IN BIOCHEMICAL SCIENCES

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres

(2010) Y. Tanno et al.   GENES & DEVELOPMENT

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

(2010) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation

(2010) Tatsuya Tsukahara et al.   NATURE

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

(2010) Yuya Yamagishi et al.   SCIENCE

Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

(2010) Alexander E. Kelly et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Sensing centromere tension: Aurora B and the regulation of kinetochore function

(2010) Michael A. Lampson et al.   TRENDS IN CELL BIOLOGY

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

(2009) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion

(2009) J. Dai et al.   JOURNAL OF CELL SCIENCE

Molecular Distinctions between Aurora A and B: A Single Residue Change Transforms Aurora A into Correctly Localized and Functional Aurora B

(2009) Fabienne Hans et al.   MOLECULAR BIOLOGY OF THE CELL

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function

(2009) J. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

(2009) S. A. Kawashima et al.   SCIENCE

Molecular Basis of Drug Resistance in Aurora Kinases

(2008) Fiona Girdler et al.   CHEMISTRY & BIOLOGY

Phosphorylation of HsMis13 by Aurora B Kinase Is Essential for Assembly of Functional Kinetochore

(2008) Yong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY