Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease

TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis

(2020) Henry L Danahay et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary artery enlargement is associated with pulmonary hypertension and decreased survival in severe cystic fibrosis: A cohort study

(2020) Aline N. Zouk et al.   PLoS One

Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A

(2020) Raquel Centeio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

Transport properties in CFTR−/− knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption

(2020) Roberta Benedetto et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TMEM16A Mediated Mucus Production in Human Airway Epithelial Cells

(2020) Inês Cabrita et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Aerosolized lancovutide in adolescents (≥12 years) and adults with cystic fibrosis – a randomized trial

(2020) Ernst Eber et al.   Journal of Cystic Fibrosis

Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

(2020) Ines Cabrita et al.   Nature Communications

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

(2019) Kent Miner et al.   Frontiers in Pharmacology

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

(2019) Karl Kunzelmann et al.   Frontiers in Pharmacology

Brevenal, a Marine Natural Product, is Anti-Inflammatory and an Immunomodulator of Macrophage and Lung Epithelial Cells

(2019) Devon Keeler et al.   Marine Drugs

Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic PAH

(2019) Rita Papp et al.   EUROPEAN RESPIRATORY JOURNAL

Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-Induced Pneumocystis Pneumonia

(2019) Francisco J. Pérez et al.   Frontiers in Microbiology

Agonism of the TMEM16A Calcium-Activated Chloride Channel Modulates Airway Smooth Muscle Tone

(2019) Jennifer Danielsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels

(2019) Michele Genovese et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38–Mitogen-activated Protein Kinase–Dependent Apoptosis

(2018) Ayed M. Allawzi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1

(2018) Joana Lérias et al.   CELLULAR SIGNALLING

Contractile Properties of Intrapulmonary Airway Smooth Muscle in Cystic Fibrosis

(2018) Oleg S. Matusovsky et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TMEM16A is indispensable for basal mucus secretion in airways and intestine

(2018) Roberta Benedetto et al.   FASEB JOURNAL

Epithelial Chloride Transport by CFTR Requires TMEM16A

(2017) Roberta Benedetto et al.   Scientific Reports

Pulmonary artery enlargement and cystic fibrosis pulmonary exacerbations: a cohort study

(2016) J Michael Wells et al.   Lancet Respiratory Medicine

Antagonists of the TMEM16A Calcium-activated Chloride Channel Modulate Airway Smooth Muscle Tone and Intracellular Calcium

(2015) Jennifer Danielsson et al.   ANESTHESIOLOGY

TMEM16A mediates the hypersecretion of mucus induced by Interleukin-13

(2015) Jiachen Lin et al.   EXPERIMENTAL CELL RESEARCH

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation

(2015) Priya Rajavelu et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2015) Christian Hammer et al.   MOLECULAR MEDICINE

Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin

(2015) Emanuela Caci et al.   PLoS One

Asthma and cystic fibrosis: A tangled web

(2014) Brian D. Kent et al.   PEDIATRIC PULMONOLOGY

How the airway smooth muscle in cystic fibrosis reacts in proinflammatory conditions: implications for airway hyper-responsiveness and asthma in cystic fibrosis

(2013) Sarah McCuaig et al.   Lancet Respiratory Medicine

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

(2012) Abigail S. Forrest et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Transmembrane Protein 16A Ca2+-activated Cl−Channel in Airway Smooth Muscle Contributes to Airway Hyperresponsiveness

(2012) Cheng-Hai Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long term effects of denufosol tetrasodium in patients with cystic fibrosis

(2012) Felix Ratjen et al.   Journal of Cystic Fibrosis

Chronic hypoxia-induced upregulation of Ca2+-activated Cl−channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity

(2012) Hui Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

(2012) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells

(2011) Walter E. Finkbeiner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

DOG1 utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration

(2011) Nazneen Fatima et al.   CANCER CYTOPATHOLOGY

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupled Nucleotide and Mucin Hypersecretion from Goblet-Cell Metaplastic Human Airway Epithelium

(2010) Seiko F. Okada et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chloride Channels: Often Enigmatic, Rarely Predictable

(2009) Charity Duran et al.   Annual Review of Physiology

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

(2009) Gang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Allergen-induced airway hyperresponsiveness is absent in ecto-5′-nucleotidase (CD73)-deficient mice

(2008) Rainer Schreiber et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulated Airway Goblet Cell Mucin Secretion

(2007) C. William Davis et al.   Annual Review of Physiology