Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma

Krebs Cycle Reborn in Macrophage Immunometabolism

(2020) Dylan G. Ryan et al.   Annual Review of Immunology

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

(2019) Alex J. Freemerman et al.   JOURNAL OF IMMUNOLOGY

Macrophage metabolism: a wound‐healing perspective

(2019) George Caputa et al.   IMMUNOLOGY AND CELL BIOLOGY

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

(2017) Donnele Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monocyte and macrophage immunometabolism in atherosclerosis

(2017) Laszlo Groh et al.   Seminars in Immunopathology

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Cancer Manipulation of Host Physiology: Lessons from Pancreatic Cancer

(2017) Constantinos P. Zambirinis et al.   TRENDS IN MOLECULAR MEDICINE

Prognostic value of GLUT-1 expression in pancreatic cancer: results from 538 patients

(2017) Gaowa Sharen et al.   Oncotarget

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

(2017) Erika M. Palmieri et al.   Cell Reports

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

(2016) Rigel J. Kishton et al.   Cell Metabolism

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 + T Cell-Mediated Immunity in Colorectal Cancer

(2016) Nupur Bhattacharya et al.   IMMUNITY

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice

(2016) H. L. Penny et al.   Cancer Immunology Research

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

(2016) Hweixian Leong Penny et al.   OncoImmunology

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis

(2015) Constantinos P. Zambirinis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Preventing Allograft Rejection by Targeting Immune Metabolism

(2015) Chen-Fang Lee et al.   Cell Reports

High Expression of HIF1a Is a Predictor of Clinical Outcome in Patients with Pancreatic Ductal Adenocarcinomas and Correlated to PDGFA, VEGF, and bFGF

(2015) Andreas-Claudius Hoffmann et al.   NEOPLASIA

Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

(2014) Haoqiang Ying et al.   CANCER RESEARCH

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

mTOR Signaling in T Cell Immunity and Autoimmunity

(2014) Yu Liu et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of tumour associated macrophages in pancreatic cancer

(2013) Ainhoa Mielgo et al.   BMB Reports

Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer

(2013) Michele T Yip-Schneider et al.   BMC CANCER

The Epidemiology of Pancreatitis and Pancreatic Cancer

(2013) Dhiraj Yadav et al.   GASTROENTEROLOGY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

(2013) Rikke B. Holmgaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia

(2011) Takushi Ooga et al.   Molecular BioSystems

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

GLUT-1 Expression in Pancreatic Neoplasia

(2011) Olca Basturk et al.   PANCREAS

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus

(2010) Armin Kolb et al.   CANCER BIOLOGY & THERAPY

Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms

(2010) Yi Liu et al.   CANCER LETTERS

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

(2010) M. Igoillo-Esteve et al.   DIABETOLOGIA

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Different effect of glutamine on macrophage tumor necrosis factor-alpha release and heat shock protein 72 expression in vitro and in vivo

(2009) M. Liang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Inflammation and pancreatic cancer: an evidence-based review

(2009) Julia B Greer et al.   CURRENT OPINION IN PHARMACOLOGY

Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles

(2009) Masahiro Sugimoto et al.   Metabolomics

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

(2008) Carolyn L. Buller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Depiction of metabolome changes in histidine-starvedEscherichia coliby CE-TOFMS

(2007) Yoshiaki Ohashi et al.   Molecular BioSystems