Regulation and Role of Transcription Factors in Osteogenesis

Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses

(2021) Jian He et al.   CELL RESEARCH

Regulation of Osteoblast Differentiation by Cytokine Networks

(2021) Dulshara Sachini Amarasekara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

(2021) Michelle M. McDonald et al.   CELL

Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia

(2021) Alessandra Guasto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Clinical Potential of Circulating miRNAs as Biomarkers: Present and Future Applications for Diagnosis and Prognosis of Age-Associated Bone Diseases

(2020) Michela Bottani et al.   Biomolecules

IRX3 and IRX5 inhibit adipogenic differentiation of hypertrophic chondrocytes and promote osteogenesis

(2020) Zhijia Tan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling

(2020) Archana Kamalakar et al.   BONE

Mechanisms of bone development and repair

(2020) Ankit Salhotra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Osteoblast-Osteoclast Communication and Bone Homeostasis

(2020) Jung-Min Kim et al.   Cells

Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development

(2020) Sophia Ka Yan Ma et al.   Frontiers in Cell and Developmental Biology

A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy

(2020) Francesco Dernie et al.   EXPERIMENTAL GERONTOLOGY

The role of microRNAs in bone development

(2020) Austin P. Hensley et al.   BONE

Circulating miRNAs in bone health and disease

(2020) Johannes Grillari et al.   BONE

TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

(2019) Hiroaki Saito et al.   Nature Communications

Deregulated miRNAs in osteoporosis: effects in bone metastasis

(2019) Daniele Bellavia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA-145 suppresses osteogenic differentiation of human jaw bone marrow mesenchymal stem cells partially via targeting semaphorin 3A

(2019) Yucui Jin et al.   CONNECTIVE TISSUE RESEARCH

Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life

(2019) Kyriel M. Pineault et al.   Nature Communications

Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis

(2019) Cátia F Gonçalves et al.   JOURNAL OF ENDOCRINOLOGY

Inhibition of CRY2 by STAT3/miRNA-7-5p Promotes Osteoblast Differentiation through Upregulation of CLOCK/BMAL1/P300 Expression

(2019) Zhenghui Tang et al.   Molecular Therapy-Nucleic Acids

MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway

(2018) Hongxia Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

(2018) Ruili Yang et al.   Nature Communications

Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

(2018) Cheng Wang et al.   eLife

Identification of the Human Skeletal Stem Cell

(2018) Charles K.F. Chan et al.   CELL

Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?

(2018) Chao Song et al.   Biomed Research International

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs

(2018) Duanjing Chen et al.   CELL PROLIFERATION

Resting zone of the growth plate houses a unique class of skeletal stem cells

(2018) Koji Mizuhashi et al.   NATURE

Parathyroid hormone-stimulation of Runx2 during osteoblast differentiation via the regulation of lnc-SUPT3H-1:16 (RUNX2-AS1:32) and miR-6797-5p

(2018) B. Arumugam et al.   BIOCHIMIE

Contribution of cranial neural crest cells to mouse skull development

(2017) Taofen Wu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2

(2017) Kayvan Zainabadi et al.   PLoS One

Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype

(2016) William E. Samsa et al.   BONE

MicroRNA-320a Regulates the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting HOXA10

(2016) Jianhou Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis

(2016) Astrid Houben et al.   DEVELOPMENT

The Circadian Gene Clock Regulates Bone Formation Via PDIA3

(2016) Gongsheng Yuan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Runx2/DICER/miRNA Pathway in Regulating Osteogenesis

(2016) Leilei Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Circulating microRNAs as novel biomarkers for bone diseases – Complex signatures for multifactorial diseases?

(2016) Matthias Hackl et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation

(2016) Peng Liu et al.   Scientific Reports

A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site

(2016) Tatsuya Kunimoto et al.   Scientific Reports

Inhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a

(2016) Yii-Shyuan Chen et al.   Scientific Reports

Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

(2016) Yujie Deng et al.   Cell Reports

Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur

(2015) Naoki Okubo et al.   Acta Orthopaedica

Bone development

(2015) Agnes D. Berendsen et al.   BONE

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

(2015) Daniel L. Worthley et al.   CELL

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

(2015) Jianwen Wei et al.   CELL

Parathyroid hormone: anabolic and catabolic actions on the skeleton

(2015) Barbara C Silva et al.   CURRENT OPINION IN PHARMACOLOGY

Skeletal stem cells

(2015) P. Bianco et al.   DEVELOPMENT

Fate of growth plate hypertrophic chondrocytes: Death or lineage extension?

(2015) Kwok Yeung Tsang et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2

(2015) Zhiqi Zhang et al.   FEBS LETTERS

MicroRNA-153 suppresses the osteogenic differentiation of human mesenchymal stem cells by targeting bone morphogenetic protein receptor type II

(2015) YUJING CAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage

(2015) J. Park et al.   Biology Open

The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness

(2014) Alexander J. Makowski et al.   BONE

Osteogenic fate of hypertrophic chondrocytes

(2014) Guan Yang et al.   CELL RESEARCH

Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose-derived stem cells

(2014) Xiaoqing Hu et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Formation of Proximal and Anterior Limb Skeleton Requires Early Function of Irx3 and Irx5 and Is Negatively Regulated by Shh Signaling

(2014) Danyi Li et al.   DEVELOPMENTAL CELL

The RUNX2 Cistrome in Osteoblasts

(2014) Mark B. Meyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Review of Osteocyte Function and the Emerging Importance of Sclerostin

(2014) Jocelyn T Compton et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

Bcl2 Deficiency Activates FoxO through Akt Inactivation and Accelerates Osteoblast Differentiation

(2014) Takeshi Moriishi et al.   PLoS One

Impaired Bone Formation in Pdia3 Deficient Mice

(2014) Yun Wang et al.   PLoS One

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis

(2014) Hai Wu et al.   GENOME BIOLOGY

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

miR-145 suppresses osteogenic differentiation by targeting Sp7

(2013) Jie Jia et al.   FEBS LETTERS

PCAF acetylates Runx2 and promotes osteoblast differentiation

(2013) Chao-Yang Wang et al.   JOURNAL OF BONE AND MINERAL METABOLISM

The circadian clock and glucocorticoids – Interactions across many time scales

(2013) Thomas Dickmeis et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Prolonged Bioluminescence Monitoring in Mouse Ex Vivo Bone Culture Revealed Persistent Circadian Rhythms in Articular Cartilages and Growth Plates

(2013) Naoki Okubo et al.   PLoS One

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology

(2012) N. Gaborit et al.   DEVELOPMENT

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2

(2012) Yang Zeng et al.   FEBS LETTERS

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1

(2012) Carine Bonnard et al.   NATURE GENETICS

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation

(2012) Mehdi Shakibaei et al.   PLoS One

MSM Enhances GH Signaling via the Jak2/STAT5b Pathway in Osteoblast-Like Cells and Osteoblast Differentiation through the Activation of STAT5b in MSCs

(2012) Youn Hee Joung et al.   PLoS One

Unraveling the role of FoxOs in bone—Insights from mouse models

(2011) Maria Almeida   BONE

A Runx2/miR-3960/miR-2861 Regulatory Feedback Loop during Mouse Osteoblast Differentiation

(2011) Rong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development

(2011) Ming Ding et al.   JOURNAL OF CELLULAR PHYSIOLOGY

GATA4 Regulates Estrogen Receptor-α-Mediated Osteoblast Transcription

(2011) Gustavo A. Miranda-Carboni et al.   MOLECULAR ENDOCRINOLOGY

Roles of SATB2 in Osteogenic Differentiation and Bone Regeneration

(2011) Jin Zhang et al.   TISSUE ENGINEERING PART A

Neural crest specification: tissues, signals, and transcription factors

(2011) C.D. Rogers et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Identification of a submicroscopic 3.2 Mb chromosomal 16q12.2-13 deletion in a child with short stature, mild developmental delay, and craniofacial anomalies, by high-density oligonucleotide array-a recognizable syndrome

(2010) Ching-Fen Chang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts

(2010) Marie-Therese Rached et al.   Cell Metabolism

Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse

(2010) Tripti Gaur et al.   DEVELOPMENTAL BIOLOGY

Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head

(2010) Paul G. Roybal et al.   DEVELOPMENTAL BIOLOGY

Foxo1, a Novel Regulator of Osteoblast Differentiation and Skeletogenesis

(2010) Cristina C. Teixeira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parathyroid hormone regulates osteoblast differentiation positively or negatively depending on the differentiation stages

(2010) Yukihiro Isogai et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Signaling networks in RUNX2-dependent bone development

(2010) Toshihisa Komori   JOURNAL OF CELLULAR BIOCHEMISTRY

Per-1 is a specific clock gene regulated by parathyroid hormone (PTH) signaling in osteoblasts and is functional for the transcriptional events induced by PTH

(2010) Ryo Hanyu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

(2010) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of bone development and extracellular matrix protein genes by RUNX2

(2009) Toshihisa Komori   CELL AND TISSUE RESEARCH

Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2

(2009) N. Funato et al.   DEVELOPMENT

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription

(2009) W. Wang et al.   DEVELOPMENT

Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo

(2009) Heidi Bildsoe et al.   DEVELOPMENTAL BIOLOGY

Anti-apoptotic Molecule Bcl-2 Regulates the Differentiation, Activation, and Survival of Both Osteoblasts and Osteoclasts

(2009) Yuichi Nagase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-141 and -200a Are Involved in Bone Morphogenetic Protein-2-induced Mouse Pre-osteoblast Differentiation by Targeting Distal-less Homeobox 5

(2009) Tomohiro Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation

(2009) Zhaoyong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origin Matters: Differences in Embryonic Tissue Origin and Wnt Signaling Determine the Osteogenic Potential and Healing Capacity of Frontal and Parietal Calvarial Bones

(2009) Natalina Quarto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Circadian Rhythm of Osteocalcin in the Maxillomandibular Complex

(2009) Y. Gafni et al.   JOURNAL OF DENTAL RESEARCH

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Critical Role of Activating Transcription Factor 4 in the Anabolic Actions of Parathyroid Hormone in Bone

(2009) Shibing Yu et al.   PLoS One

Osteoclast–osteoblast communication

(2008) Koichi Matsuo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation

(2008) Jung Hee Suh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-Induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation

(2008) Amjad Javed et al.   CELLS TISSUES ORGANS

Sox9 Inhibits Wnt Signaling by Promoting β-Catenin Phosphorylation in the Nucleus

(2008) Lilia Topol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive Regulation of Adult Bone Formation by Osteoblast-Specific Transcription Factor Osterix

(2008) Wook-Young Baek et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nightshift work and fracture risk: the Nurses’ Health Study

(2008) D. Feskanich et al.   OSTEOPOROSIS INTERNATIONAL

Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix

(2008) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endochondral ossification: How cartilage is converted into bone in the developing skeleton

(2007) E.J. Mackie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY