Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

(2018) Tokio Matsuzaki et al.   Science Translational Medicine

Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases

(2018) Somponnat Sampattavanich et al.   Cell Systems

Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation

(2016) M. C. Gómez-Puerto et al.   Autophagy

TNF-α Inhibits FoxO1 by Upregulating miR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis

(2016) Li Liao et al.   STEM CELLS

Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients

(2016) L Wang et al.   Cell Death & Disease

Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism

(2015) Kang I. Ko et al.   DIABETOLOGIA

Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice

(2015) Virtu Calabuig-Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-21 Modulates the Immunoregulatory Function of Bone Marrow Mesenchymal Stem Cells Through the PTEN/Akt/TGF-β1 Pathway

(2015) Tingting Wu et al.   STEM CELLS

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

(2015) Fatemeh Atashi et al.   STEM CELLS AND DEVELOPMENT

AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1

(2014) Hee Yun et al.   FEBS Journal

Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors

(2014) Srividhya Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcl2 Deficiency Activates FoxO through Akt Inactivation and Accelerates Osteoblast Differentiation

(2014) Takeshi Moriishi et al.   PLoS One

FoxO6 and PGC-1α form a regulatory loop in myogenic cells

(2013) Shih Ying Chung et al.   BIOSCIENCE REPORTS

Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1

(2013) Daisuke Kajimura et al.   Cell Metabolism

Human-specific microRNA regulation of FOXO1: implications for microRNA recognition element evolution

(2013) H. S. McLoughlin et al.   HUMAN MOLECULAR GENETICS

FOXOs attenuate bone formation by suppressing Wnt signaling

(2013) Srividhya Iyer et al.   JOURNAL OF CLINICAL INVESTIGATION

FoxO6 in glucose metabolism (FoxO6在葡萄糖代谢中的作用)

(2013) Dae Hyun Kim et al.   Journal of Diabetes

Wnt signaling in bone formation and its therapeutic potential for bone diseases

(2013) Jeong Hwan Kim et al.   Therapeutic Advances in Musculoskeletal Disease

FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway

(2012) Jingyi Zhou et al.   Autophagy

Transcriptional targeting by microRNA-Polycomb complexes: A novel route in cell fate determination

(2012) Giuseppe Zardo et al.   CELL CYCLE

FoxO1 and FoxM1 Transcription Factors Have Antagonistic Functions in Neonatal Cardiomyocyte Cell-Cycle Withdrawal and IGF1 Gene Regulation

(2012) Arunima Sengupta et al.   CIRCULATION RESEARCH

FoxO6 regulates memory consolidation and synaptic function

(2012) D. A. M. Salih et al.   GENES & DEVELOPMENT

miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1

(2012) Kyoung Min Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Concise Review: Clinical Translation of Wound Healing Therapies Based on Mesenchymal Stem Cells

(2012) Wesley M. Jackson et al.   Stem Cells Translational Medicine

PI3K-AKT-FoxO axis in cancer and aging

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FOXO1 modulates osteoblast differentiation

(2011) Michelle F. Siqueira et al.   BONE

Foxo1 Mediates Insulin-like Growth Factor 1 (IGF1)/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in Osteoblasts

(2011) Shengyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts

(2011) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation

(2011) Xianwang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

(2011) J.-w. Hwang et al.   JOURNAL OF IMMUNOLOGY

Wnt Signaling Regulates Hepatic Metabolism

(2011) H. Liu et al.   Science Signaling

Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress

(2010) Bo Shen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

The Extending Network of FOXO Transcriptional Target Genes

(2010) Kristan E. van der Vos et al.   ANTIOXIDANTS & REDOX SIGNALING

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

(2010) Keertik Fulzele et al.   CELL

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

(2010) Mathieu Ferron et al.   CELL

Osteoblast physiology in normal and pathological conditions

(2010) Anna Neve et al.   CELL AND TISSUE RESEARCH

microRNA(interference) networks are embedded in the gene regulatory networks

(2010) Letizia Pitto et al.   CELL CYCLE

FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice

(2010) Elena Ambrogini et al.   Cell Metabolism

FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts

(2010) Marie-Therese Rached et al.   Cell Metabolism

Foxo1, a Novel Regulator of Osteoblast Differentiation and Skeletogenesis

(2010) Cristina C. Teixeira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-α mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis Through FOXO1

(2010) Rayyan A Kayal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Polymorphisms in predicted miRNA binding sites and osteoporosis

(2010) Shu-Feng Lei et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis

(2009) Luca Dalle Carbonare et al.   ARTHRITIS AND RHEUMATISM

Regulation of bone development and extracellular matrix protein genes by RUNX2

(2009) Toshihisa Komori   CELL AND TISSUE RESEARCH

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

(2009) Ji-hye Paik et al.   Cell Stem Cell

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

FoxO proteins: cunning concepts and considerations for the cardiovascular system

(2009) Kenneth Maiese et al.   CLINICAL SCIENCE

FoxO4 Inhibits NF-κB and Protects Mice Against Colonic Injury and Inflammation

(2009) Wen Zhou et al.   GASTROENTEROLOGY

The Transcription of FOXO Genes Is Stimulated by FOXO3 and Repressed by Growth Factors

(2009) Ahmed Essaghir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation

(2009) Zhaoyong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans

(2009) Hui Li et al.   JOURNAL OF CLINICAL INVESTIGATION

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

(2009) Marie-Therese Rached et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteogenic potential and responsiveness to leptin of mesenchymal stem cells between postmenopausal women with osteoarthritis and osteoporosis

(2009) Zi-Ming Zhang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A microRNA regulatory mechanism of osteoblast differentiation

(2009) H. Inose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin and JNK: optimizing metabolic homeostasis and lifespan

(2009) Jason Karpac et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression

(2008) Ippei Kanazawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene

(2008) MeiShiue Kuo et al.   FEBS LETTERS

Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

(2008) Diana Hoogeboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

FOXO-binding partners: it takes two to tango

(2008) K E van der Vos et al.   ONCOGENE

A microRNA signature for a BMP2-induced osteoblast lineage commitment program

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinated Changes of Mitochondrial Biogenesis and Antioxidant Enzymes During Osteogenic Differentiation of Human Mesenchymal Stem Cells

(2008) Chien-Tsun Chen et al.   STEM CELLS