Antitumor Effect of Organometallic Half-Sandwich Ru(II)–Arene Complexes Bearing a Glutathione S-Transferase Inhibitor

Discovery of 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol Derivatives as Glutathione Transferase Inhibitors with Favorable Selectivity and Tolerated Toxicity

(2021) Qingqing Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glutathione S-Transferases in Cancer

(2021) Rahul Raj Singh et al.   Antioxidants

Design of a Tris-Heteroleptic Ru(II) Complex with Red-Light Excitation and Remarkably Improved Photobiological Activity

(2020) Shuang Li et al.   INORGANIC CHEMISTRY

Ruthenium(II) Phosphine/Mercapto Complexes: Their in Vitro Cytotoxicity Evaluation and Actions as Inhibitors of Topoisomerase and Proteasome Acting as Possible Triggers of Cell Death Induction

(2020) Gabriel H. Ribeiro et al.   INORGANIC CHEMISTRY

Mitochondria-Targeting Click-Derived Pyridinyltriazolylmethylquinoxaline-Based Y-Shaped Binuclear Luminescent Ruthenium(II) and Iridium(III) Complexes as Cancer Theranostic Agents

(2020) Nilmadhab Roy et al.   INORGANIC CHEMISTRY

Using bioorthogonally catalyzed lethality strategy to generate mitochondria-targeting antitumor metallodrugs in vitro and in vivo

(2020) Xuling Xue et al.   National Science Review

Dinuclear Organoruthenium Complexes Exhibiting Antiproliferative Activity through DNA Damage and a Reactive-Oxygen-Species-Mediated Endoplasmic Reticulum Stress Pathway

(2019) Jian Zhao et al.   INORGANIC CHEMISTRY

NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry

(2019) Enzo Alessio et al.   MOLECULES

Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

(2018) Samuel M. Meier-Menches et al.   CHEMICAL SOCIETY REVIEWS

Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug

(2018) Keefe Guang Zhi Lee et al.   ChemMedChem

Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing P^P-Chelating Ligands: A New Class of Potent Anticancer Agents with Unusual Redox Features

(2018) JuanJuan Li et al.   INORGANIC CHEMISTRY

Hypoxia-Targeting Organometallic Ru(II)–Arene Complexes with Enhanced Anticancer Activity in Hypoxic Cancer Cells

(2018) Jian Zhao et al.   INORGANIC CHEMISTRY

Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria

(2018) Hongjian He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anticancer Activity of Bifunctional Organometallic Ru(II) Arene Complexes Containing a 7-Hydroxycoumarin Group

(2018) Jian Zhao et al.   ORGANOMETALLICS

Mitochondria-targeted half-sandwich rutheniumII diimine complexes: anticancer and antimetastasis via ROS-mediated signalling

(2018) Zhishan Xu et al.   Inorganic Chemistry Frontiers

Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes

(2017) Lucinda K. Batchelor et al.   INORGANIC CHEMISTRY

Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms

(2017) Yaqing Ye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Glutathione S-Transferase Inhibitors

(2017) Emilia Păunescu et al.   ORGANOMETALLICS

Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies

(2017) Mun Juinn Chow et al.   Chemical Science

The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis

(2017) Anastasia De Luca et al.   Oncotarget

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

The development of RAPTA compounds for the treatment of tumors

(2016) Benjamin S. Murray et al.   COORDINATION CHEMISTRY REVIEWS

Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

(2016) Enzo Alessio   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates

(2016) Christoph A. Riedl et al.   INORGANIC CHEMISTRY

Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines

(2016) Jun Du et al.   INORGANIC CHEMISTRY

Structural and Biochemical Analyses Reveal the Mechanism of GlutathioneS-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine

(2016) Wayne Harshbarger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity

(2016) Gabriele Agonigi et al.   ORGANOMETALLICS

Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance

(2016) Mun Juinn Chow et al.   Chemical Science

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands

(2015) Gabriele Agonigi et al.   INORGANIC CHEMISTRY

Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with β-Diketonates

(2015) Sara Seršen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells

(2015) Jun Du et al.   Metallomics

A novel orally active water-soluble Inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts

(2015) Anastasia De Luca et al.   Oncotarget

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

(2013) Wei Zheng et al.   CHEMICAL COMMUNICATIONS

Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds

(2013) I. Cummins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione S-transferase P1-1 as a target for mesothelioma treatment

(2012) Anastasia De Luca et al.   CANCER SCIENCE

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

(2011) Muhammad Hanif et al.   CHEMICAL COMMUNICATIONS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance

(2011) Katarina Johansson et al.   MOLECULAR PHARMACEUTICS

Glutathione transferases and development of new principles to overcome drug resistance

(2010) Andrea Sau et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases

(2009) L. Federici et al.   CANCER RESEARCH

Ruthenium(II) Arene Anticancer Complexes with Redox-Active Diamine Ligands

(2009) Tijana Bugarcic et al.   INORGANIC CHEMISTRY

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

(2008) Christian G. Hartinger et al.   CHEMISTRY & BIODIVERSITY