Short-Chain Fatty Acids as a Potential Treatment for Infections: a Closer Look at the Lungs

Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis

(2021) Jian-jian Ji et al.   ACTA PHARMACOLOGICA SINICA

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

(2021) Yun Kit Yeoh et al.   GUT

Preventing Respiratory Tract Infections by Synbiotic Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2020) Carty K Y Chan et al.   Advances in Nutrition

Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

(2020) Valentin Sencio et al.   Cell Reports

Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza

(2020) Silan Gu et al.   CLINICAL INFECTIOUS DISEASES

Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge

(2020) Tao Zuo et al.   GASTROENTEROLOGY

Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

(2020) Tanvi Shinde et al.   Microorganisms

Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice

(2019) Xiaoli Tian et al.   Frontiers in Microbiology

Evaluation of encapsulated sodium butyrate with varying releasing times on growth performance and necrotic enteritis mitigation in broilers

(2019) J D Liu et al.   POULTRY SCIENCE

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Sodium butyrate inhibits planktonic cells and biofilms of Trichosporon spp.

(2019) Rossana de Aguiar Cordeiro et al.   MICROBIAL PATHOGENESIS

Microbes, metabolites, and the gut–lung axis

(2019) Anh Thu Dang et al.   Mucosal Immunology

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

(2019) José Luís Fachi et al.   Cell Reports

Beyond Gut Instinct: Metabolic Short-Chain Fatty Acids Moderate the Pathogenesis of Alphaherpesviruses

(2019) Katrien C. K. Poelaert et al.   Frontiers in Microbiology

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

(2019) Krist Helen Antunes et al.   Nature Communications

Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans

(2019) Jack Guinan et al.   Scientific Reports

Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

(2019) Konrad C. Bradley et al.   Cell Reports

Propionate Ameliorates Staphylococcus aureus Skin Infection by Attenuating Bacterial Growth

(2019) Soyoung Jeong et al.   Frontiers in Microbiology

Pathogenic Fungal Infection in the Lung

(2019) Zhi Li et al.   Frontiers in Immunology

Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation

(2019) Gavin Lewis et al.   Frontiers in Immunology

Propionate, together with triple antibiotics, inhibits the growth of Enterococci

(2019) Soyoung Jeong et al.   JOURNAL OF MICROBIOLOGY

Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate

(2019) Natalie A. Prow et al.   Frontiers in Immunology

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2

(2019) José Luís Fachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D3 as host directed therapy

(2018) Rokeya Sultana Rekha et al.   BMC INFECTIOUS DISEASES

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing

(2018) Zhiwei Ang et al.   FASEB JOURNAL

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Short-Chain Fatty Acids (SCFAs) alter metabolic and virulence attributes of Borrelia burgdorferi

(2018) Ying-Han Lin et al.   INFECTION AND IMMUNITY

Daily adjunctive therapy with vitamin D3 and phenylbutyrate supports clinical recovery from pulmonary tuberculosis: a randomized controlled trial in Ethiopia

(2018) A. Bekele et al.   JOURNAL OF INTERNAL MEDICINE

The effects of prebiotic supplementation on weight gain, diarrhoea, constipation, fever and respiratory tract infections in the first year of life

(2018) Iraj Shahramian et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung

(2018) Izabela Galvão et al.   Frontiers in Immunology

Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis

(2018) Soner Yildiz et al.   Microbiome

A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection

(2018) Amanda Jacobson et al.   Cell Host & Microbe

Early Dietary Intervention with a Mixture of Prebiotic Oligosaccharides Reduces the Incidence of Allergic Manifestations and Infections during the First Two Years of Life

(2018) Sertac Arslanoglu et al.   JOURNAL OF NUTRITION

The influence of orally administered short chain fatty acids on intestinal histopathological changes and intensity of Trichinella spiralis infection in mice

(2018) D. Mista et al.   VETERINARNI MEDICINA

Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome

(2018) Ravinder Nagpal et al.   Scientific Reports

Sodium acetate inhibits Staphylococcus aureus internalization into bovine mammary epithelial cells by inhibiting NF-κB activation

(2017) Zhengkai Wei et al.   MICROBIAL PATHOGENESIS

Effect of organic acids on biofilm formation and quorum signaling of pathogens from fresh fruits and vegetables

(2017) Balagopal Amrutha et al.   MICROBIAL PATHOGENESIS

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids

(2017) A Cait et al.   Mucosal Immunology

Microbiota-Derived Short-Chain Fatty Acids Modulate Expression of Campylobacter jejuni Determinants Required for Commensalism and Virulence

(2017) Paul M. Luethy et al.   mBio

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

(2017) Donjete Statovci et al.   Frontiers in Immunology

Butyrate Supplementation at High Concentrations Alters Enteric Bacterial Communities and Reduces Intestinal Inflammation in Mice Infected with Citrobacter rodentium

(2017) Janelle A. Jiminez et al.   mSphere

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome

(2016) Jeremy P. McAleer et al.   JOURNAL OF IMMUNOLOGY

Oral intake of Lactobacillus rhamnosus M21 enhances the survival rate of mice lethally infected with influenza virus

(2016) Jeong Ah Song et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Probiotics for prevention and treatment of respiratory tract infections in children

(2016) Yizhong Wang et al.   MEDICINE

Control of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 5 1A

(2016) Angélica T. Vieira et al.   MICROBES AND INFECTION

Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications

(2016) Suellen Ferro et al.   Oncotarget

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

(2016) Elisa Deriu et al.   PLoS Pathogens

Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.

(2016) Allison Agus et al.   Scientific Reports

Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition

(2016) Haitao Xiong et al.   Scientific Reports

Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo

(2016) Eleonora Ciarlo et al.   Scientific Reports

The Role of Short-Chain Fatty Acids, Produced by Anaerobic Bacteria, in the Cystic Fibrosis Airway

(2015) Bojana Mirković et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth

(2015) Peyman Ghorbani et al.   EUROPEAN RESPIRATORY JOURNAL

Efficacy of 1% acetic acid in the treatment of chronic wounds infected withPseudomonas aeruginosa: prospective randomised controlled clinical trial

(2015) VL Madhusudhan   International Wound Journal

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Influence of H7N9 virus infection and associated treatment on human gut microbiota

(2015) Nan Qin et al.   Scientific Reports

Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D₃

(2015) Anna K. Coussens et al.   PLoS Pathogens

Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial

(2015) Akhirunnesa Mily et al.   PLoS One

Pectin- Derived Acidic Oligosaccharides Improve the Outcome of Pseudomonas aeruginosa Lung Infection in C57BL/6 Mice

(2015) Henry Bernard et al.   PLoS One

Probiotics in respiratory virus infections

(2014) L. Lehtoranta et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

(2014) Jian Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Increase in dietary fiber dampens allergic responses in the lung

(2014) Gary B Huffnagle   NATURE MEDICINE

Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial

(2013) Raakel Luoto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral intake of phenylbutyrate with or without vitamin D3upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis

(2013) Akhirunnesa Mily et al.   BMC Pulmonary Medicine

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

(2012) Noura Kechaou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial

(2012) Rubhana Raqib et al.   BMC INFECTIOUS DISEASES

Fatty Acids Regulate Stress Resistance and Virulence Factor Production for Listeria monocytogenes

(2012) Y. Sun et al.   JOURNAL OF BACTERIOLOGY

Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)

(2012) Ivano Moschen et al.   NEUROCHEMICAL RESEARCH

Modulation of Antimicrobial Host Defense Peptide Gene Expression by Free Fatty Acids

(2012) Lakshmi T. Sunkara et al.   PLoS One

Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms

(2011) Chifu B. Huang et al.   ARCHIVES OF ORAL BIOLOGY

Sodium butyrate inhibits pathogenic yeast growth and enhances the functions of macrophages

(2011) L. N. Nguyen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Transient TLR Activation Restores Inflammatory Response and Ability To Control Pulmonary Bacterial Infection in Germfree Mice

(2011) C. T. Fagundes et al.   JOURNAL OF IMMUNOLOGY

Butyrate Enhances Disease Resistance of Chickens by Inducing Antimicrobial Host Defense Peptide Gene Expression

(2011) Lakshmi T. Sunkara et al.   PLoS One

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Motility by Sensing Short-Chain Fatty Acids via Two Steps in a Flagellar Gene Regulatory Cascade in EnterohemorrhagicEscherichia coli

(2010) Toru Tobe et al.   INFECTION AND IMMUNITY

Effect of intranasal administration of Lactobacillus pentosus S-PT84 on influenza virus infection in mice

(2010) Takayuki Izumo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses

(2010) G. Harata et al.   LETTERS IN APPLIED MICROBIOLOGY

Phenylbutyrate Induces Antimicrobial Peptide Expression

(2009) J. Steinmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sodium butyrate inhibits Staphylococcus aureus internalization in bovine mammary epithelial cells and induces the expression of antimicrobial peptide genes

(2009) Alejandra Ochoa-Zarzosa et al.   MICROBIAL PATHOGENESIS

Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli

(2009) N. Nakanishi et al.   MICROBIOLOGY-SGM

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Short-chain fatty acids andl-lactate as feed additives to controlCampylobacter jejuniinfections in broilers

(2008) Kim Van Deun et al.   AVIAN PATHOLOGY

Butyrate protects Caco-2 cells from Campylobacter jejuni invasion and translocation

(2008) Kim Van Deun et al.   BRITISH JOURNAL OF NUTRITION

Effects of short chain fatty acids on effector mechanisms of neutrophils

(2008) Marco A. R. Vinolo et al.   CELL BIOCHEMISTRY AND FUNCTION

Coated fatty acids alter virulence properties of Salmonella Typhimurium and decrease intestinal colonization of pigs

(2008) F. Boyen et al.   VETERINARY MICROBIOLOGY