Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo

Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis

(2016) Athina Savva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates

(2016) Thierry Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical shock strategies to reactivate latent HIV-1

(2016) Gilles Darcis et al.   Current Opinion in HIV and AIDS

Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline

(2016) Hao Chen et al.   PLoS Computational Biology

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Infection risk associated with anti-TNF-α agents: a review

(2015) Giuseppe Murdaca et al.   Expert Opinion On Drug Safety

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

(2015) Carolina Iraporda et al.   IMMUNOBIOLOGY

Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1  via a Caspase-1-Independent Mechanism

(2015) D. Stammler et al.   JOURNAL OF IMMUNOLOGY

Emerging single-cell technologies in immunology

(2015) Jacobus Herderschee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate Immune Sensing ofFusarium culmorumby Mouse Dendritic Cells

(2015) Gaëlle Vacher et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial

(2015) Craig H Moskowitz et al.   LANCET

Sepsis: a roadmap for future research

(2015) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

(2015) Stephan Meller et al.   NATURE IMMUNOLOGY

HDAC inhibitors still need a home run, despite recent approval

(2015) Malini Guha   NATURE REVIEWS DRUG DISCOVERY

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

The effect of short-chain fatty acids on human monocyte-derived dendritic cells

(2015) Claudia Nastasi et al.   Scientific Reports

From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology

(2014) Niranjana Natarajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Finding the Missing Links among Metabolites, Microbes, and the Host

(2014) Pieter C. Dorrestein et al.   IMMUNITY

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders

(2014) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Enemy attraction: bacterial agonists for leukocyte chemotaxis receptors

(2014) Dominik Alexander Bloes et al.   NATURE REVIEWS MICROBIOLOGY

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OpenCyto: An Open Source Infrastructure for Scalable, Robust, Reproducible, and Automated, End-to-End Flow Cytometry Data Analysis

(2014) Greg Finak et al.   PLoS Computational Biology

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

(2014) Richard Brad Jones et al.   PLoS Pathogens

Contributions of Colonic Short-Chain Fatty Acid Receptors in Energy Homeostasis

(2014) Atsukazu Kuwahara   Frontiers in Endocrinology

The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock

(2013) Jérôme Lugrin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Normalization of mass cytometry data with bead standards

(2013) Rachel Finck et al.   CYTOMETRY PART A

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Valproic Acid Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2013) Mu-huo Ji et al.   INFLAMMATION

G Protein-Coupled Receptor 43 Moderates Gut Inflammation Through Cytokine Regulation from Mononuclear Cells

(2013) Ryuta Masui et al.   INFLAMMATORY BOWEL DISEASES

Epigenetics in sepsis: targeting histone deacetylases

(2013) Eleonora Ciarlo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The Response of Secondary Genes to Lipopolysaccharides in Macrophages Depends on Histone Deacetylase and Phosphorylation of C/EBP 

(2013) N. Serrat et al.   JOURNAL OF IMMUNOLOGY

G protein coupled-receptor signaling and reversible lysine acetylation

(2013) Bryan D. Spiegelberg   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Innate immune recognition of the microbiota promotes host-microbial symbiosis

(2013) Hiutung Chu et al.   NATURE IMMUNOLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases

(2013) Athina Savva et al.   Frontiers in Immunology

Butyrate increases IL-23 production by stimulated dendritic cells

(2012) Bradford E. Berndt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Release of macrophage migration inhibitory factor by neuroendocrine-differentiated LNCaP cells sustains the proliferation and survival of prostate cancer cells

(2012) Thomas Tawadros et al.   ENDOCRINE-RELATED CANCER

Histone deacetylase inhibitors: a patent review (2009 – 2011)

(2012) Vincenzo Carafa et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non–Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy

(2012) Samir E. Witta et al.   JOURNAL OF CLINICAL ONCOLOGY

Macrophage Migration Inhibitory Factor Deficiency Is Associated With Impaired Killing of Gram-Negative Bacteria by Macrophages and Increased Susceptibility to Klebsiella pneumoniae Sepsis

(2012) Thierry Roger et al.   JOURNAL OF INFECTIOUS DISEASES

Modulation of Antimicrobial Host Defense Peptide Gene Expression by Free Fatty Acids

(2012) Lakshmi T. Sunkara et al.   PLoS One

Histone Deacetylase Inhibitors Impair Antibacterial Defenses of Macrophages

(2011) Matteo Mombelli et al.   JOURNAL OF INFECTIOUS DISEASES

Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial

(2011) Anas Younes et al.   LANCET ONCOLOGY

Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia hasin vitrobut limited clinical activity

(2011) Steven Lane et al.   LEUKEMIA & LYMPHOMA

Histone deacetylases as regulators of inflammation and immunity

(2011) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

(2010) T. Roger et al.   BLOOD

Histone Deacetylase Inhibitors Attenuate Acute Lung Injury During Cecal Ligation and Puncture-Induced Polymicrobial Sepsis

(2010) Li Zhang et al.   WORLD JOURNAL OF SURGERY

Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation

(2009) Jérôme Lugrin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human genetics of infectious diseases: between proof of principle and paradigm

(2009) Alexandre Alcaïs et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PROTECTIVE EFFECT OF SUBEROYLANILIDE HYDROXAMIC ACID AGAINST LPS-INDUCED SEPTIC SHOCK IN RODENTS

(2009) Yongqing Li et al.   SHOCK