The cancer biology of whole-chromosome instability

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Haploinsufficiency ofSGO1results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis

(2012) Hiroshi Y. Yamada et al.   CELL CYCLE

Killing cells by targeting mitosis

(2012) E Manchado et al.   CELL DEATH AND DIFFERENTIATION

S-phase fraction and ploidy as predictive markers in primary disease and recurrence of papillary thyroid carcinoma

(2012) António E. Pinto et al.   CLINICAL ENDOCRINOLOGY

Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells

(2012) Lilian Kabeche et al.   CURRENT BIOLOGY

How Do Cytokines Trigger Genomic Instability?

(2012) Ioannis L. Aivaliotis et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Expression of tumour-specific antigens underlies cancer immunoediting

(2012) Michel DuPage et al.   NATURE

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

Natural outcome of trisomy 13, trisomy 18, and triploidy after prenatal diagnosis

(2011) Ioana Claudia Lakovschek et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Oncogene-Induced Mitotic Stress: p53 and pRb Get Mad Too

(2011) Marcos Malumbres   CANCER CELL

Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

(2011) Juan-Manuel Schvartzman et al.   CANCER CELL

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Tumor-Specific Antigens and Immunologic Adjuvants in Cancer Immunotherapy

(2011) Teofila Seremet et al.   CANCER JOURNAL

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

(2011) Pengfei Liu et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Two Distinct Routes to Oral Cancer Differing in Genome Instability and Risk for Cervical Node Metastasis

(2011) A. Bhattacharya et al.   CLINICAL CANCER RESEARCH

Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors

(2011) P. Lagarde et al.   CLINICAL CANCER RESEARCH

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

DNA Ploidy is Stronger Than Lymph Node Metastasis as Prognostic Factor in Cervical Carcinoma

(2011) Tommaso Susini et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

(2011) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice

(2011) Malini Mukherjee et al.   PLoS One

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

(2011) D. A. Solomon et al.   SCIENCE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Proteolytic networks in cancer

(2011) Steven D. Mason et al.   TRENDS IN CELL BIOLOGY

Getting through anaphase: splitting the sisters and beyond

(2010) Raquel A. Oliveira et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas

(2010) Hiroaki Sato et al.   BMC CANCER

Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes

(2010) Marcel Smid et al.   BREAST CANCER RESEARCH AND TREATMENT

High chromosomal instability in brain metastases of colorectal carcinoma

(2010) Angelika Gutenberg et al.   CANCER GENETICS AND CYTOGENETICS

Oncogenic B-RafV600E Induces Spindle Abnormalities, Supernumerary Centrosomes, and Aneuploidy in Human Melanocytic Cells

(2010) Y. Cui et al.   CANCER RESEARCH

BRAF Inactivation Drives Aneuploidy by Deregulating CRAF

(2010) T. Kamata et al.   CANCER RESEARCH

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy

(2010) Sarah E. McClelland et al.   CELL CYCLE

A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering

(2010) P Karna et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive

(2010) C. H. Coschi et al.   GENES & DEVELOPMENT

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

(2010) T. van Harn et al.   GENES & DEVELOPMENT

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates

(2010) Pallavi Lonkar et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

(2010) Janine H. van Ree et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

(2010) Rocio Sotillo et al.   NATURE

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Local Recurrence after Breast-Conserving Therapy in Relation to Gene Expression Patterns in a Large Series of Patients

(2009) B. Kreike et al.   CLINICAL CANCER RESEARCH

Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential

(2009) Arne Warth et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Deregulated Aurora-B induced tetraploidy promotes tumorigenesis

(2009) Hao G. Nguyen et al.   FASEB JOURNAL

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2

(2009) Nadja Bitomsky et al.   FEBS Journal

Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice

(2009) Min Li et al.   JOURNAL OF CELL BIOLOGY

Perioperative Activation of Disseminated Tumor Cells in Bone Marrow of Patients With Prostate Cancer

(2009) Dorothea Weckermann et al.   JOURNAL OF CLINICAL ONCOLOGY

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

(2009) D. T. Terrano et al.   MOLECULAR AND CELLULAR BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer

(2009) Philippe L. Bedard et al.   Nature Reviews Clinical Oncology

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal instability determines taxane response

(2009) C. Swanton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Direct Genetic Analysis of Single Disseminated Cancer Cells for Prediction of Outcome and Therapy Selection in Esophageal Cancer

(2008) Nikolas H. Stoecklein et al.   CANCER CELL

Small Molecule Targeting the Hec1/Nek2 Mitotic Pathway Suppresses Tumor Cell Growth in Culture and in Animal

(2008) G. Wu et al.   CANCER RESEARCH

Impaired Bub1 Function In vivo Compromises Tension-Dependent Checkpoint Function Leading to Aneuploidy and Tumorigenesis

(2008) M. Schliekelman et al.   CANCER RESEARCH

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Integrative Genomic Analysis of Aneuploidy in Uveal Melanoma

(2008) J. P. Ehlers et al.   CLINICAL CANCER RESEARCH

Immune surveillance: a balance between protumor and antitumor immunity

(2008) Suzanne Ostrand-Rosenberg   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

(2008) A Walther et al.   GUT

Aurora A Is Essential for Early Embryonic Development and Tumor Suppression

(2008) Lin-Yu Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aneuploidy, but not Ki-67 or EGFR expression, is associated with recurrences in basal cell carcinoma

(2008) Delphine Janisson-Dargaud et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients

(2008) Chang-Min Choi et al.   LUNG CANCER

Polo-Like Kinase 1 Is Essential for Early Embryonic Development and Tumor Suppression

(2008) L.-Y. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

(2008) Irene García-Higuera et al.   NATURE CELL BIOLOGY

Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice

(2008) D Zhang et al.   ONCOGENE

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

(2008) E. Diaz-Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY

Whole chromosome instability and cancer: a complex relationship

(2008) Robin M. Ricke et al.   TRENDS IN GENETICS