Carbohydrate-containing nanoparticles as vaccine adjuvants

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

(2021) Carlo Pifferi et al.   Nature Reviews Chemistry

Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant

(2021) Elisabeth Mahase   BMJ-British Medical Journal

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Influenza Virus Like Particles (VLPs): Opportunities for H7N9 Vaccine Development

(2020) Peter Pushko et al.   Viruses-Basel

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

(2020) Cheryl Keech et al.   NEW ENGLAND JOURNAL OF MEDICINE

Carbohydrate Immune Adjuvants in Subunit Vaccines

(2020) Sahra Bashiri et al.   Pharmaceutics

Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines

(2020) Iman M. Alfagih et al.   Pharmaceutics

Nanovaccine: A novel approach in immunization

(2019) Seyed Mohammad Gheibi Hayat et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Corn-derived alpha-D-glucan nanoparticles as adjuvant for intramuscular and intranasal immunization in pigs

(2019) Santosh Dhakal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Immunological basis for enhanced immunity of nanoparticle vaccines

(2019) Hannah G Kelly et al.   Expert Review of Vaccines

Immunomodulatory effects of Alhagi honey polysaccharides encapsulated into PLGA nanoparticles

(2019) Adelijiang Wusiman et al.   CARBOHYDRATE POLYMERS

HPMA‐Based Nanocarriers for Effective Immune System Stimulation

(2019) Stefan Kramer et al.   MACROMOLECULAR BIOSCIENCE

“Stuck on sugars – how carbohydrates regulate cell adhesion, recognition, and signaling”

(2019) Richard D. Cummings   GLYCOCONJUGATE JOURNAL

Electrostatic interactions: From immune receptor assembly to signaling

(2019) Audrey Connolly et al.   IMMUNOLOGICAL REVIEWS

RTS,S/AS01 Vaccine (Mosquirix™) : An overview

(2019) Matthew B. Laurens   Human Vaccines & Immunotherapeutics

Mucosal Immune System of Cattle

(2019) Christopher Chase et al.   VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE

An immunopotentiator, ophiopogonin D, encapsulated in a nanoemulsion as a robust adjuvant to improve vaccine efficacy

(2018) Ya-nan Tong et al.   Acta Biomaterialia

Synthesis of Beta-glucan Nanoparticles for the Delivery of Single Strand DNA

(2018) Jangsun Hwang et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Curdlan sulfate–O-linked quaternized chitosan nanoparticles: potential adjuvants to improve the immunogenicity of exogenous antigens via intranasal vaccination

(2018) Shu Zhang et al.   International Journal of Nanomedicine

A strong adjuvant based on glycol-chitosan-coated lipid-polymer hybrid nanoparticles potentiates mucosal immune responses against the recombinant Chlamydia trachomatis fusion antigen CTH522

(2018) Fabrice Rose et al.   JOURNAL OF CONTROLLED RELEASE

Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination

(2018) Yufei Xia et al.   NATURE MATERIALS

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

(2018) Giuseppe Del Giudice et al.   SEMINARS IN IMMUNOLOGY

Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants

(2018) Dante J. Marciani   TRENDS IN PHARMACOLOGICAL SCIENCES

Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles

(2018) Mei Zhang et al.   Frontiers in Immunology

Synergistic effect of dual targeting vaccine adjuvant with aminated β-glucan and CpG-oligodeoxynucleotides for both humoral and cellular immune responses

(2018) Jing Wei Jin et al.   Acta Biomaterialia

Immunomodulatory properties of chitosan polymers

(2018) Hannah B.T. Moran et al.   BIOMATERIALS

Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles

(2018) F. Lebre et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses

(2018) Samuel Paulo Cibulski et al.   Scientific Reports

Mannose impairs tumour growth and enhances chemotherapy

(2018) Pablo Sierra Gonzalez et al.   NATURE

Nanoparticle Vaccines Against Infectious Diseases

(2018) Rashmirekha Pati et al.   Frontiers in Immunology

N-Oxy lipid-based click chemistry for orthogonal coupling of mannan onto nanoliposomes prepared by microfluidic mixing: Synthesis of lipids, characterisation of mannan-coated nanoliposomes and in vitro stimulation of dendritic cells

(2018) Eliška Bartheldyová et al.   CARBOHYDRATE POLYMERS

Calcium phosphate nanoparticles as a new generation vaccine adjuvant

(2017) Yahua Lin et al.   Expert Review of Vaccines

Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant

(2017) JiHui Zhao et al.   International Journal of Nanomedicine

Adjuvant Activity of Poly-ε-caprolactone/Chitosan Nanoparticles Characterized by Mast Cell Activation and IFN-γ and IL-17 Production

(2017) Sandra Jesus et al.   MOLECULAR PHARMACEUTICS

D-mannose induces regulatory T cells and suppresses immunopathology

(2017) Dunfang Zhang et al.   NATURE MEDICINE

Safety and immunogenicity of heterologous prime-boost immunization with viral-vectored malaria vaccines adjuvanted with Matrix-M™

(2017) Navin Venkatraman et al.   VACCINE

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

(2017) Margherita Coccia et al.   npj Vaccines

Chitosan Nanoparticles Prepared by Ionotropic Gelation: An Overview of Recent Advances

(2016) Kashappa Goud Desai   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Species-dependent role of type I IFNs and IL-12 in the CTL response induced by humanized CpG complexed with β-glucan

(2016) Kouji Kobiyama et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Surface-functionalized, pH-responsive poly(lactic-co-glycolic acid)-based microparticles for intranasal vaccine delivery: Effect of surface modification with chitosan and mannan

(2016) Ze Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Enhancing dendritic cell activation and HIV vaccine effectiveness through nanoparticle vaccination

(2016) Joshua J. Glass et al.   Expert Review of Vaccines

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

(2016) Elizabeth. C. Carroll et al.   IMMUNITY

Improving adjuvanticity of quaternized chitosan–based microgels for H5N1 split vaccine by tailoring the particle properties to achieve antigen dose sparing effect

(2016) Yue-Qi Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Antibacterial Nanoparticles in Endodontics: A Review

(2016) Annie Shrestha et al.   JOURNAL OF ENDODONTICS

Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 Glucan

(2016) Nida S. Khan et al.   JOURNAL OF IMMUNOLOGY

Saponin Interactions with Model Membrane Systems – Langmuir Monolayer Studies, Hemolysis and Formation of ISCOMs

(2016) Carolin de Groot et al.   PLANTA MEDICA

Novel ISCOMs from Quillaja brasiliensis saponins induce mucosal and systemic antibody production, T-cell responses and improved antigen uptake

(2016) Samuel Paulo Cibulski et al.   VACCINE

Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation

(2016) Rina F. Villar et al.   Scientific Reports

A heterogén glikoproteinszerkezetek biológiai szerepe

(2016) Lajos Jakab   ORVOSI HETILAP

Nanoengineering of vaccines using natural polysaccharides

(2015) Ana Sara Cordeiro et al.   BIOTECHNOLOGY ADVANCES

Low-dose cyclophosphamide enhances antigen-specific CD4+ T cell responses to NY-ESO-1/ISCOMATRIX™ vaccine in patients with advanced melanoma

(2015) Oliver Klein et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Carbohydrate-based vaccine adjuvants – discovery and development

(2015) Jing Hu et al.   Expert Opinion on Drug Discovery

Shape and size-dependent immune response to antigen-carrying nanoparticles

(2015) Sunny Kumar et al.   JOURNAL OF CONTROLLED RELEASE

Mucoadhesive glycol chitosan nanoparticles for intranasal delivery of hepatitis B vaccine: enhancement of mucosal and systemic immune response

(2014) Dilip Pawar et al.   DRUG DELIVERY

Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope

(2014) Katie J. Doores et al.   JOURNAL OF VIROLOGY

The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells

(2014) Joseph H. Lorent et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

(2014) Michelle Tate et al.   Viruses-Basel

Single low-dose un-adjuvanted HBsAg nanoparticle vaccine elicits robust, durable immunity

(2013) Amit A. Lugade et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticle vaccines

(2013) Liang Zhao et al.   VACCINE

Vaccines against mucosal infections

(2012) Jan Holmgren et al.   CURRENT OPINION IN IMMUNOLOGY

T-Helper 1 Cells Elicited by H5N1 Vaccination Predict Seroprotection

(2012) Gabriel K. Pedersen et al.   JOURNAL OF INFECTIOUS DISEASES

Synthesis of a novel kind of carbon nanoparticle with large mesopores and macropores and its application as an oral vaccine adjuvant

(2011) Tianyi Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Carbohydrate-based immune adjuvants

(2011) Nikolai Petrovsky et al.   Expert Review of Vaccines

ISCOM technology-based Matrix M™ adjuvant: success in future vaccines relies on formulation

(2011) Karin Lövgren Bengtsson et al.   Expert Review of Vaccines

Chitosan but Not Chitin Activates the Inflammasome by a Mechanism Dependent upon Phagocytosis

(2011) Chelsea L. Bueter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gold Nanoparticles Coated with Oligomannosides of HIV-1 Glycoprotein gp120 Mimic the Carbohydrate Epitope of Antibody 2G12

(2011) Marco Marradi et al.   JOURNAL OF MOLECULAR BIOLOGY

Enhanced Immune Response Against Pertussis Toxoid by IgA-Loaded Chitosan–Dextran Sulfate Nanoparticles

(2011) Sameer Sharma et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Kinetics of coacervation transition versus nanoparticle formation in chitosan–sodium tripolyphosphate solutions

(2010) Mandeep Kaloti et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Carbohydrate-based vaccines: challenges and opportunities

(2010) Yen-Lin Huang et al.   Expert Review of Vaccines

Liposomes modified by carbohydrate ligands can target B cells for the treatment of B-cell lymphomas

(2010) Geert-Jan Boons   Expert Review of Vaccines

β-Glucans and Dectin-1

(2009) S. Vicky Tsoni et al.   Annals of the New York Academy of Sciences

Proteoglycan signaling co-receptors: Roles in cell adhesion, migration and invasion

(2009) Karthikeyan Mythreye et al.   CELLULAR SIGNALLING

Mannose-binding lectin and innate immunity

(2009) W. K. Eddie Ip et al.   IMMUNOLOGICAL REVIEWS

The potential of glycol chitosan nanoparticles as carrier for low water soluble drugs

(2009) Adriana Trapani et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Trimethyl chitosan and its applications in drug delivery

(2009) V. K. Mourya et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Amplified immune response by ginsenoside-based nanoparticles (ginsomes)

(2009) Xiaoming Song et al.   VACCINE

ISCOMs and ISCOMATRIX™

(2009) Hong-Xiang Sun et al.   VACCINE

Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: In vitro and in vivo evaluation

(2008) Amandeep Kaur et al.   ACTA PHARMACEUTICA

New Bioactive Biomaterials Based on Quaternized Chitosan

(2008) Rachid Belalia et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY