Carbohydrate-based vaccine adjuvants – discovery and development

Local tolerance and systemic toxicity of single and repeated intramuscular administrations of two different formulations of the RTS,S malaria candidate vaccine in rabbits

(2015) Lawrence Segal et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Nonclinical reproductive and developmental safety evaluation of the MAGE-A3 Cancer Immunotherapeutic, a therapeutic vaccine for cancer treatment

(2015) E. Destexhe et al.   REPRODUCTIVE TOXICOLOGY

A gold glyco-nanoparticle carrying a listeriolysin O peptide and formulated with Advax™ delta inulin adjuvant induces robust T-cell protection against listeria infection

(2015) Estela Rodriguez-Del Rio et al.   VACCINE

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS-21 induce strong humoral and cellular immune responses against hepatitis B surface antigen which persist for at least 4 years after vaccination

(2015) Geert Leroux-Roels et al.   VACCINE

Advax-Adjuvanted Recombinant Protective Antigen Provides Protection against Inhalational Anthrax That Is Further Enhanced by Addition of Murabutide Adjuvant

(2014) Brandon Feinen et al.   Clinical and Vaccine Immunology

Non-clinical safety evaluation of single and repeated intramuscular administrations of MAGE-A3 Cancer Immunotherapeutic in rabbits and cynomolgus monkeys

(2014) Eric Destexhe et al.   JOURNAL OF APPLIED TOXICOLOGY

Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells

(2014) Arnaud M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Development of a minimal saponin vaccine adjuvant based on QS-21

(2014) Alberto Fernández-Tejada et al.   Nature Chemistry

Immunogenicity and safety of Advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: A randomized controlled Phase 1 study

(2014) David Gordon et al.   VACCINE

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

(2014) Jaap T. van Dissel et al.   VACCINE

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

(2013) Olga Vera-Lastra et al.   Expert Review of Clinical Immunology

The polysaccharide inulin is characterized by an extensive series of periodic isoforms with varying biological actions

(2013) P. D. Cooper et al.   GLYCOBIOLOGY

Control of Chronic Mycobacterium tuberculosis Infection by CD4 KLRG1- IL-2-Secreting Central Memory Cells

(2013) T. Lindenstrom et al.   JOURNAL OF IMMUNOLOGY

An Inactivated Cell Culture Japanese Encephalitis Vaccine (JE-ADVAX) Formulated with Delta Inulin Adjuvant Provides Robust Heterologous Protection against West Nile Encephalitis via Cross-Protective Memory B Cells and Neutralizing Antibody

(2013) N. Petrovsky et al.   JOURNAL OF VIROLOGY

Development of Soluble Inulin Microparticles as a Potent and Safe Vaccine Adjuvant and Delivery System

(2013) Sunny Kumar et al.   MOLECULAR PHARMACEUTICS

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer

(2013) Y.-L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel hepatitis B vaccine containing Advax™, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing

(2013) Fadi Saade et al.   VACCINE

The mycobacterial cord factor adjuvant analogue trehalose-6,6′-dibehenate (TDB) activates the Nlrp3 inflammasome

(2012) Katrin Schweneker et al.   IMMUNOBIOLOGY

Vaccine-Induced Th17 Cells Are Maintained Long-Term Postvaccination as a Distinct and Phenotypically Stable Memory Subset

(2012) Thomas Lindenstrøm et al.   INFECTION AND IMMUNITY

Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes

(2012) Eric K. Chea et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New pathways of protective and pathological host defense to mycobacteria

(2012) Tom H.M. Ottenhoff   TRENDS IN MICROBIOLOGY

Randomized clinical trial of immunogenicity and safety of a recombinant H1N1/2009 pandemic influenza vaccine containing Advax™ polysaccharide adjuvant

(2012) David L. Gordon et al.   VACCINE

Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses

(2012) Yoshikazu Honda-Okubo et al.   VACCINE

Carbohydrate-based immune adjuvants

(2011) Nikolai Petrovsky et al.   Expert Review of Vaccines

Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

(2011) Govind Ragupathi et al.   Expert Review of Vaccines

Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems

(2011) Nathalie Garçon et al.   Expert Review of Vaccines

A multistage tuberculosis vaccine that confers efficient protection before and after exposure

(2011) Claus Aagaard et al.   NATURE MEDICINE

Development of a dried influenza whole inactivated virus vaccine for pulmonary immunization

(2011) Sandrine A.L. Audouy et al.   VACCINE

Delta inulin: a novel, immunologically active, stable packing structure comprising  -D-[2 -> 1] poly(fructo-furanosyl)  -D-glucose polymers

(2010) P. D. Cooper et al.   GLYCOBIOLOGY

An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses

(2010) M. Lobigs et al.   JOURNAL OF GENERAL VIROLOGY

Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations

(2010) A. D. Cristillo et al.   JOURNAL OF GENERAL VIROLOGY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Design and Synthesis of PotentQuillajaSaponin Vaccine Adjuvants

(2010) Michelle M. Adams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of the intramuscular administration of Cervarix™ vaccine on fertility, pre- and post-natal development in rats

(2010) Lawrence Segal et al.   REPRODUCTIVE TOXICOLOGY

Pollinex Quattro Tree: allergy vaccine

(2009) Sandra M Gawchik et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

(2009) Caglar Cekic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation

(2009) Kerstin Werninghaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Advances in saponin-based adjuvants

(2009) Hong-Xiang Sun et al.   VACCINE

Synthesis of QS-21-Xylose: Establishment of the Immunopotentiating Activity of Synthetic QS-21 Adjuvant with a Melanoma Vaccine

(2008) Kai Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs

(2008) D QUENELLE et al.   ANTIVIRAL RESEARCH