Biological Evaluation and Docking Analysis of Potent BACE1 Inhibitors from Boesenbergia rotunda

Pinostrobin exerts neuroprotective actions in neurotoxin-induced Parkinson’s disease models through Nrf2 induction

(2018) Chuwen Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

BACE1 Inhibition by Genistein: Biological Evaluation, Kinetic Analysis, and Molecular Docking Simulation

(2018) Kumju Youn et al.   JOURNAL OF MEDICINAL FOOD

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling

(2018) Gaia Botteri et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage

(2017) Shoujiao Peng et al.   Food & Function

Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression

(2017) Shirley James et al.   Scientific Reports

Identification of Indole-Based Chalcones: Discovery of a Potent, Selective, and Reversible Class of MAO-B Inhibitors

(2016) Rani Sasidharan et al.   ARCHIV DER PHARMAZIE

Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells

(2016) Yumin Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor

(2016) Kumju Youn et al.   Nutrients

Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs

(2016) Riqiang Yan   Translational Neurodegeneration

Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion

(2015) Muhammed A. Saad et al.   Pharmacological Reports

Cardamonin, a schistosomicidal chalcone from Piper aduncum L. (Piperaceae) that inhibits Schistosoma mansoni ATP diphosphohydrolase

(2015) Clarissa C.B. de Castro et al.   PHYTOMEDICINE

Pinocembrin Attenuates 6-OHDA-induced Neuronal Cell Death Through Nrf2/ARE Pathway in SH-SY5Y Cells

(2014) Xiaohua Jin et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

(2014) Saeed Sadigh-Eteghad et al.   MEDICAL PRINCIPLES AND PRACTICE

Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits

(2014) Rui Liu et al.   NEUROBIOLOGY OF AGING

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro

(2012) Tomohiro Mizutani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis

(2012) Rui Liu et al.   BMC Medicine

Protective Effects of Pinostrobin on β-Amyloid-Induced Neurotoxicity in PC12 Cells

(2012) Yan-Fang Xian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Diammonium Glycyrrhizinate Attenuates Aβ1-42-Induced Neuroinflammation and Regulates MAPK and NF-κB PathwaysIn VitroandIn Vivo

(2012) Hui Zhao et al.   CNS Neuroscience & Therapeutics

Boesenbergia rotunda: From Ethnomedicine to Drug Discovery

(2012) Tan Eng-Chong et al.   Evidence-based Complementary and Alternative Medicine

Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway

(2012) Yuh-Lit Chow et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Uptake characteristics of pinocembrin and its effect on p-glycoprotein at the blood–brain barrier inin vitrocell experiments

(2012) Zhi-Hong Yang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Developing β-secretase inhibitors for treatment of Alzheimer’s disease

(2011) Arun K. Ghosh et al.   JOURNAL OF NEUROCHEMISTRY

Pathways linking Aβ and tau pathologies: Figure 1

(2010) Frank M. LaFerla   BIOCHEMICAL SOCIETY TRANSACTIONS

REVIEW: γ-Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State

(2010) Francesco Panza et al.   CNS Neuroscience & Therapeutics

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia–reperfusion both in vivo and in vitro

(2008) Rui Liu et al.   BRAIN RESEARCH

Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

(2008) Kavon Rezai-Zadeh et al.   BRAIN RESEARCH

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA