Generating human hematopoietic stem cellsin vitro-exploring endothelial to hematopoietic transition as a portal for stemness acquisition

Pluripotent stem cell based gene therapy for hematological diseases

(2016) Stijn Vanhee et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver

(2016) Stanislav Rybtsov et al.   DEVELOPMENT

Complex regulation of HSC emergence by the Notch signaling pathway

(2016) Emerald Butko et al.   DEVELOPMENTAL BIOLOGY

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Medial HOXA genes demarcate haematopoietic stem cell fate during human development

(2016) Diana R. Dou et al.   NATURE CELL BIOLOGY

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

(2016) Céline Souilhol et al.   Nature Communications

De novo generation of HSCs from somatic and pluripotent stem cell sources

(2015) L. T. Vo et al.   BLOOD

GPI-80 Defines Self-Renewal Ability in Hematopoietic Stem Cells during Human Development

(2015) Sacha Leandra Prashad et al.   Cell Stem Cell

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros–derived hematopoietic stem cells

(2015) Brandon K. Hadland et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells

(2015) Jennifer L. Gori et al.   JOURNAL OF CLINICAL INVESTIGATION

The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate

(2015) V Ayllón et al.   LEUKEMIA

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

(2015) Andrea Ditadi et al.   NATURE CELL BIOLOGY

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

(2015) Roshana Thambyrajah et al.   NATURE CELL BIOLOGY

Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells

(2015) Kran Suknuntha et al.   Stem Cell Research

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity

(2015) Jenna M. Frame et al.   STEM CELLS

Human Induced Pluripotent Stem Cell-Derived B Lymphocytes Express sIgM and Can Be Generated via a Hemogenic Endothelium Intermediate

(2015) Anna French et al.   STEM CELLS AND DEVELOPMENT

Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition

(2015) Carlos O. Lizama et al.   Nature Communications

CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus

(2015) HyunJun Kang et al.   Molecular Therapy-Nucleic Acids

In Vivo Repopulating Activity Emerges at the Onset of Hematopoietic Specification during Embryonic Stem Cell Differentiation

(2015) Stella Pearson et al.   Stem Cell Reports

Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts

(2015) Sara E. Howden et al.   Stem Cell Reports

Retinoic Acid Regulates Hematopoietic Development from Human Pluripotent Stem Cells

(2015) Roger E. Rönn et al.   Stem Cell Reports

HOXA9 promotes hematopoietic commitment of human embryonic stem cells

(2014) V. Ramos-Mejia et al.   BLOOD

Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates

(2014) Q. He et al.   BLOOD

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

(2014) Raquel Espín-Palazón et al.   CELL

Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors

(2014) Jonah Riddell et al.   CELL

Cell interactions and cell signaling during hematopoietic development

(2014) C. Drevon et al.   EXPERIMENTAL CELL RESEARCH

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

(2014) Yan Li et al.   GENES & DEVELOPMENT

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

(2014) S. Vanhee et al.   HAEMATOLOGICA

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction

(2014) Vladislav M. Sandler et al.   NATURE

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1

(2014) Phong Dang Nguyen et al.   NATURE

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells

(2014) Christopher M Sturgeon et al.   NATURE BIOTECHNOLOGY

Lymphoid Progenitor Emergence in the Murine Embryo and Yolk Sac Precedes Stem Cell Detection

(2014) Yang Lin et al.   STEM CELLS AND DEVELOPMENT

Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators

(2014) Irina Elcheva et al.   Nature Communications

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells

(2014) Luhan Yang et al.   Nature Communications

FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway

(2014) Claire Pouget et al.   Nature Communications

Direct Reprogramming of Murine Fibroblasts to Hematopoietic Progenitor Cells

(2014) Kiran Batta et al.   Cell Reports

Tracing the Origin of the HSC Hierarchy Reveals an SCF-Dependent, IL-3-Independent CD43− Embryonic Precursor

(2014) Stanislav Rybtsov et al.   Stem Cell Reports

Tenascin C Promotes Hematoendothelial Development and T Lymphoid Commitment from Human Pluripotent Stem Cells in Chemically Defined Conditions

(2014) Gene Uenishi et al.   Stem Cell Reports

Identification of the Niche and Phenotype of the First Human Hematopoietic Stem Cells

(2014) Andrejs Ivanovs et al.   Stem Cell Reports

Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells

(2013) I. I. Slukvin   BLOOD

Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs

(2013) S. Gordon-Keylock et al.   BLOOD

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells

(2013) J. B. Lee et al.   BLOOD

Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells

(2013) Ryo Yamamoto et al.   CELL

Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development

(2013) Bhaskar Chanda et al.   CELL

Induction of a Hemogenic Program in Mouse Fibroblasts

(2013) Carlos-Filipe Pereira et al.   Cell Stem Cell

Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors

(2013) Sergei Doulatov et al.   Cell Stem Cell

Endothelio-Mesenchymal Interaction Controls runx1 Expression and Modulates the notch Pathway to Initiate Aortic Hematopoiesis

(2013) Charlotte Richard et al.   DEVELOPMENTAL CELL

Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control

(2013) Kathrina L. Marcelo et al.   DEVELOPMENTAL CELL

Gata2is required for HSC generation and survival

(2013) Emma de Pater et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation of Engraftable Hematopoietic Stem Cells From Induced Pluripotent Stem Cells by Way of Teratoma Formation

(2013) Nao Suzuki et al.   MOLECULAR THERAPY

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

The expression of Sox17 identifies and regulates haemogenic endothelium

(2013) Raedun L. Clarke et al.   NATURE CELL BIOLOGY

Sox17 is indispensable for acquisition and maintenance of arterial identity

(2013) Monica Corada et al.   Nature Communications

Haemogenic endocardium contributes to transient definitive haematopoiesis

(2013) Haruko Nakano et al.   Nature Communications

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

(2013) Gemma Swiers et al.   Nature Communications

APELIN promotes hematopoiesis from human embryonic stem cells

(2012) Q. C. Yu et al.   BLOOD

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition

(2012) S. Rafii et al.   BLOOD

Role of SOX17 in hematopoietic development from human embryonic stem cells

(2012) Y. Nakajima-Takagi et al.   BLOOD

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells

(2012) G. Amabile et al.   BLOOD

Mouse Embryonic Head as a Site for Hematopoietic Stem Cell Development

(2012) Zhuan Li et al.   Cell Stem Cell

The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny

(2012) Shannon McKinney-Freeman et al.   Cell Stem Cell

Modeling human hematopoietic cell development from pluripotent stem cells

(2012) Melanie D. Kardel et al.   EXPERIMENTAL HEMATOLOGY

Hematopoietic stem cell development requires transient Wnt/β-catenin activity

(2012) Cristina Ruiz-Herguido et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Identification of the Hemogenic Endothelial Progenitor and Its Direct Precursor in Human Pluripotent Stem Cell Differentiation Cultures

(2012) Kyung-Dal Choi et al.   Cell Reports

T Lymphocyte Potential Marks the Emergence of Definitive Hematopoietic Progenitors in Human Pluripotent Stem Cell Differentiation Cultures

(2012) Marion Kennedy et al.   Cell Reports

Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells

(2011) Michael J. Chen et al.   Cell Stem Cell

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

(2011) Andrejs Ivanovs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region

(2011) Stanislav Rybtsov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Investigating monogenic and complex diseases with pluripotent stem cells

(2011) Hao Zhu et al.   NATURE REVIEWS GENETICS

Human embryonic stem cell-derived CD34+ cells function as MSC progenitor cells

(2010) Ross A. Kopher et al.   BONE

A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells

(2010) Maxim A. Vodyanik et al.   Cell Stem Cell

Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos

(2010) T. Yokomizo et al.   DEVELOPMENT

Direct conversion of human fibroblasts to multilineage blood progenitors

(2010) Eva Szabo et al.   NATURE

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

HoxA3 is an apical regulator of haemogenic endothelium

(2010) Michelina Iacovino et al.   NATURE CELL BIOLOGY

Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells

(2009) D. S. Kaufman   BLOOD

Hedgehog and Bmp Polarize Hematopoietic Stem Cell Emergence in the Zebrafish Dorsal Aorta

(2009) Robert N. Wilkinson et al.   DEVELOPMENTAL CELL

Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell–derived lin–CD34+CD43+CD45+ progenitors

(2009) Kyung-Dal Choi et al.   JOURNAL OF CLINICAL INVESTIGATION

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Continuous single-cell imaging of blood generation from haemogenic endothelium

(2009) Hanna M. Eilken et al.   NATURE

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

WNT and BMP signaling are both required for hematopoietic cell development from human ES cells

(2009) Yi Wang et al.   Stem Cell Research

Hematopoietic and endothelial differentiation of human induced pluripotent stem cells

(2009) Kyung-Dal Choi et al.   STEM CELLS

Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis

(2008) L. C. Goldie et al.   BLOOD

Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming

(2008) Rudolf Jaenisch et al.   CELL

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis

(2008) Giorgia Salvagiotto et al.   EXPERIMENTAL HEMATOLOGY

Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene

(2008) M. Seandel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA