The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate

Identification of the Niche and Phenotype of the First Human Hematopoietic Stem Cells

(2014) Andrejs Ivanovs et al.   Stem Cell Reports

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells

(2013) J. B. Lee et al.   BLOOD

A short history of hemogenic endothelium

(2013) Gemma Swiers et al.   BLOOD CELLS MOLECULES AND DISEASES

Integrin  IIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta

(2013) J.-C. Boisset et al.   Biology Open

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition

(2012) S. Rafii et al.   BLOOD

The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny

(2012) Shannon McKinney-Freeman et al.   Cell Stem Cell

Hematopoietic stem cell development requires transient Wnt/β-catenin activity

(2012) Cristina Ruiz-Herguido et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling

(2012) Jordi Guiu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SCL/TAL1 Regulates Hematopoietic Specification From Human Embryonic Stem Cells

(2012) Pedro J Real et al.   MOLECULAR THERAPY

The Notch Ligand Delta-Like 4 Regulates Multiple Stages of Early Hemato-Vascular Development

(2012) Ricardo Laranjeiro et al.   PLoS One

Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition

(2012) P. G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic development of hematopoietic stem cells: implications for clinical use

(2012) Thomas Clapes et al.   Regenerative Medicine

Origin of blood cells and HSC production in the embryo

(2012) Guilherme Costa et al.   TRENDS IN IMMUNOLOGY

The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm

(2011) Melina Grigorian et al.   DEVELOPMENTAL BIOLOGY

Stepwise arteriovenous fate acquisition during mammalian vasculogenesis

(2011) Diana C. Chong et al.   DEVELOPMENTAL DYNAMICS

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region

(2011) Stanislav Rybtsov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Maintenance of Human Embryonic Stem Cells in Mesenchymal Stem Cell-Conditioned Media Augments Hematopoietic Specification

(2011) Verónica Ramos-Mejía et al.   STEM CELLS AND DEVELOPMENT

Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo

(2010) J. Y. Bertrand et al.   BLOOD

VE-cadherin expression allows identification of a new class of hematopoietic stem cells within human embryonic liver

(2010) E. Oberlin et al.   BLOOD

Portrayal of the Notch System in Embryonic Stem Cell-Derived Embryoid Bodies

(2010) Isabel Alcobia et al.   CELLS TISSUES ORGANS

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

(2010) Monica Corada et al.   DEVELOPMENTAL CELL

Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit

(2010) Vincenza Caolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

(2010) Kohei Yamamizu et al.   JOURNAL OF CELL BIOLOGY

Nodal/Activin Signaling Predicts Human Pluripotent Stem Cell Lines Prone to Differentiate Toward the Hematopoietic Lineage

(2010) Veronica Ramos-Mejia et al.   MOLECULAR THERAPY

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Use of Human Embryonic Stem Cells to Understand Hematopoiesis and Hematopoietic Stem Cell Niche

(2010) Mohammad Saiful Islam et al.   Current Stem Cell Research & Therapy

Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-II

(2009) Rosa Montes et al.   CELL RESEARCH

Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues

(2009) Juan Carlos Martinez et al.   HISTOPATHOLOGY

Continuous single-cell imaging of blood generation from haemogenic endothelium

(2009) Hanna M. Eilken et al.   NATURE

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

(2008) Rui Benedito et al.   BMC DEVELOPMENTAL BIOLOGY

Notch Signaling Activation in Human Embryonic Stem Cells Is Required for Embryonic, but Not Trophoblastic, Lineage Commitment

(2008) Xiaobing Yu et al.   Cell Stem Cell

Extensive Hematopoietic Stem Cell Generation in the AGM Region via Maturation of VE-Cadherin+CD45+ Pre-Definitive HSCs

(2008) Samir Taoudi et al.   Cell Stem Cell

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1

(2008) Àlex Robert-Moreno et al.   EMBO JOURNAL

Delta-like 4 is indispensable in thymic environment specific for T cell development

(2008) Katsuto Hozumi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxc Transcription Factors Directly Regulate Dll4 and Hey2 Expression by Interacting with the VEGF-Notch Signaling Pathways in Endothelial Cells

(2008) Hisaki Hayashi et al.   PLoS One