Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation

(2013) B. W. Smith et al.   BLOOD

RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells

(2013) D. Ran et al.   BLOOD

Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cells

(2013) Igor I. Slukvin   CELL CYCLE

Defining the path to hematopoietic stem cells

(2013) Christopher M Sturgeon et al.   NATURE BIOTECHNOLOGY

The expression of Sox17 identifies and regulates haemogenic endothelium

(2013) Raedun L. Clarke et al.   NATURE CELL BIOLOGY

APELIN promotes hematopoiesis from human embryonic stem cells

(2012) Q. C. Yu et al.   BLOOD

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition

(2012) S. Rafii et al.   BLOOD

Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence

(2012) M. Yoshimoto et al.   BLOOD

Role of SOX17 in hematopoietic development from human embryonic stem cells

(2012) Y. Nakajima-Takagi et al.   BLOOD

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells

(2012) G. Amabile et al.   BLOOD

Mouse Embryonic Head as a Site for Hematopoietic Stem Cell Development

(2012) Zhuan Li et al.   Cell Stem Cell

The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny

(2012) Shannon McKinney-Freeman et al.   Cell Stem Cell

The Promise and Perils of Stem Cell Therapeutics

(2012) George Q. Daley   Cell Stem Cell

Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application

(2012) Naoya Takayama et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Progress made in the reprogramming field: new factors, new strategies and a new outlook

(2012) Samer MI Hussein et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The expanding frontier of hematopoietic cell transplantation

(2012) Thomas R. Spitzer et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Modeling human hematopoietic cell development from pluripotent stem cells

(2012) Melanie D. Kardel et al.   EXPERIMENTAL HEMATOLOGY

Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

(2012) L. Kobari et al.   HAEMATOLOGICA

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling

(2012) Jordi Guiu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of the Hemogenic Endothelial Progenitor and Its Direct Precursor in Human Pluripotent Stem Cell Differentiation Cultures

(2012) Kyung-Dal Choi et al.   Cell Reports

Human induced pluripotent stem cells are capable of B-cell lymphopoiesis

(2011) L. Carpenter et al.   BLOOD

Hematopoietic stem cell engineering at a crossroads

(2011) I. Riviere et al.   BLOOD

TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy

(2011) Chengyan Wang et al.   CELL RESEARCH

Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells

(2011) Michael J. Chen et al.   Cell Stem Cell

Disease Correction the iPSC Way: Advances in iPSC-Based Therapy

(2011) I Sancho-Martinez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

Methods for making induced pluripotent stem cells: reprogramming à la carte

(2011) Federico González et al.   NATURE REVIEWS GENETICS

A Defined, Feeder-Free, Serum-Free System to Generate In Vitro Hematopoietic Progenitors and Differentiated Blood Cells from hESCs and hiPSCs

(2011) Giorgia Salvagiotto et al.   PLoS One

A Novel Serum-Free Monolayer Culture for Orderly Hematopoietic Differentiation of Human Pluripotent Cells via Mesodermal Progenitors

(2011) Akira Niwa et al.   PLoS One

Production of Embryonic and Fetal-Like Red Blood Cells from Human Induced Pluripotent Stem Cells

(2011) Chan-Jung Chang et al.   PLoS One

Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential

(2011) M. Yoshimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemogenic endothelium: Origins, regulation, and implications for vascular biology

(2011) Joan P. Zape et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Brief Report: Efficient Generation of Hematopoietic Precursors and Progenitors from Human Pluripotent Stem Cell Lines

(2011) Niels-Bjarne Woods et al.   STEM CELLS

Inability of Human Induced Pluripotent Stem Cell-Hematopoietic Derivatives to Downregulate MicroRNAs In Vivo Reveals a Block in Xenograft Hematopoietic Regeneration

(2011) Ruth M. Risueño et al.   STEM CELLS

Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells

(2011) Jessica Dias et al.   STEM CELLS AND DEVELOPMENT

Human embryonic stem cell-derived CD34+ cells function as MSC progenitor cells

(2010) Ross A. Kopher et al.   BONE

SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells

(2010) Zhenzhi Chng et al.   Cell Stem Cell

A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells

(2010) Maxim A. Vodyanik et al.   Cell Stem Cell

Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos

(2010) T. Yokomizo et al.   DEVELOPMENT

Direct conversion of human fibroblasts to multilineage blood progenitors

(2010) Eva Szabo et al.   NATURE

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

HoxA3 is an apical regulator of haemogenic endothelium

(2010) Michelina Iacovino et al.   NATURE CELL BIOLOGY

Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells

(2009) D. S. Kaufman   BLOOD

A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis

(2009) O. Klimchenko et al.   BLOOD

Noncanonical Wnt Signaling Orchestrates Early Developmental Events toward Hematopoietic Cell Fate from Human Embryonic Stem Cells

(2009) Kausalia Vijayaragavan et al.   Cell Stem Cell

Enhanced generation of hematopoietic cells from human hepatocarcinoma cell−stimulated human embryonic and induced pluripotent stem cells

(2009) Min Lu et al.   EXPERIMENTAL HEMATOLOGY

Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell–derived lin–CD34+CD43+CD45+ progenitors

(2009) Kyung-Dal Choi et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones

(2009) F. Timmermans et al.   JOURNAL OF IMMUNOLOGY

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Continuous single-cell imaging of blood generation from haemogenic endothelium

(2009) Hanna M. Eilken et al.   NATURE

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

Early Cell Fate Decisions of Human Embryonic Stem Cells and Mouse Epiblast Stem Cells Are Controlled by the Same Signalling Pathways

(2009) Ludovic Vallier et al.   PLoS One

Bioluminescent Imaging Demonstrates That Transplanted Human Embryonic Stem Cell-Derived CD34+Cells Preferentially Develop into Endothelial Cells

(2009) Xinghui Tian et al.   STEM CELLS

Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells

(2009) Kyung-Dal Choi et al.   STEM CELLS

Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells

(2008) E. T. Zambidis et al.   BLOOD

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Efficient Hematopoietic Differentiation of Human Embryonic Stem Cells on Stromal Cells Derived from Hematopoietic Niches

(2008) Maria H. Ledran et al.   Cell Stem Cell

Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/ -catenin, Activin/Nodal and BMP signaling

(2008) T. Sumi et al.   DEVELOPMENT

Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis

(2008) Giorgia Salvagiotto et al.   EXPERIMENTAL HEMATOLOGY

Molecular profiling of candidate human hematopoietic stem cells derived from human embryonic stem cells

(2008) Farbod Shojaei et al.   EXPERIMENTAL HEMATOLOGY

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

(2008) Lei Yang et al.   NATURE