Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis

Integrative Identification of Deregulated MiRNA/TF-Mediated Gene Regulatory Loops and Networks in Prostate Cancer

(2014) Ali Sobhi Afshar et al.   PLoS One

Pharmaco-miR: linking microRNAs and drug effects

(2013) J. L. Rukov et al.   BRIEFINGS IN BIOINFORMATICS

Diabetes in Cystic Fibrosis

(2013) Nicola Bridges   Paediatric Respiratory Reviews

Exploration of miRNA families for hypotheses generation

(2013) Timothy K. K. Kamanu et al.   Scientific Reports

SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression

(2012) X. Liu et al.   BIOINFORMATICS

The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma

(2012) Tanja Heimberger et al.   BRITISH JOURNAL OF HAEMATOLOGY

Glucocorticoids reduce inflammation in cystic fibrosis bronchial epithelial cells

(2012) Carine Rebeyrol et al.   CELLULAR SIGNALLING

In silico drug repositioning – what we need to know

(2012) Zhichao Liu et al.   DRUG DISCOVERY TODAY

Integration of MicroRNA Databases to Study MicroRNAs Associated with Multiple Sclerosis

(2012) Charlotte Angerstein et al.   MOLECULAR NEUROBIOLOGY

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data

(2012) Jian-Hua Yang et al.   NUCLEIC ACIDS RESEARCH

MiR-101 and miR-144 Regulate the Expression of the CFTR Chloride Channel in the Lung

(2012) Fatemat Hassan et al.   PLoS One

A microRNA network regulates expression and biosynthesis of wild-type and  F508 mutant cystic fibrosis transmembrane conductance regulator

(2012) S. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncovering MicroRNA and Transcription Factor Mediated Regulatory Networks in Glioblastoma

(2012) Jingchun Sun et al.   PLoS Computational Biology

Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis

(2011) S. M. Innis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

microRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene

(2011) Austin E. Gillen et al.   BIOCHEMICAL JOURNAL

Drug repositioning for orphan diseases

(2011) D. Sardana et al.   BRIEFINGS IN BIOINFORMATICS

MicroRNAs and cystic fibrosis – an epigenetic perspective

(2011) Wenming Xu et al.   CELL BIOLOGY INTERNATIONAL

In silico repositioning of approved drugs for rare and neglected diseases

(2011) Sean Ekins et al.   DRUG DISCOVERY TODAY

Elevated miR-155 Promotes Inflammation in Cystic Fibrosis by Driving Hyperexpression of Interleukin-8

(2011) Sharmistha Bhattacharyya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes

(2011) Harsh Dweep et al.   JOURNAL OF BIOMEDICAL INFORMATICS

A cis-regulatory map of the Drosophila genome

(2011) Nicolas Nègre et al.   NATURE

Developing the Sentinel System — A National Resource for Evidence Development

(2011) Rachel E. Behrman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disease Ontology: a backbone for disease semantic integration

(2011) L. M. Schriml et al.   NUCLEIC ACIDS RESEARCH

Synergistic Post-Transcriptional Regulation of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) by miR-101 and miR-494 Specific Binding

(2011) Francesca Megiorni et al.   PLoS One

Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease

(2011) T. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target

(2011) Adam Collison et al.   BMC Pulmonary Medicine

Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress

(2011) Ronald C. Taylor et al.   PLoS Computational Biology

A Novel microRNA and transcription factor mediated regulatory network in schizophrenia

(2010) An-Yuan Guo et al.   BMC Systems Biology

Glucocorticoids Modulate MicroRNA Expression and Processing during Lymphocyte Apoptosis

(2010) Lindsay K. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression

(2010) Irene K. Oglesby et al.   JOURNAL OF IMMUNOLOGY

Pharmacological correction of a defect in PPAR-γ signaling ameliorates disease severity in Cftr-deficient mice

(2010) Gregory S Harmon et al.   NATURE MEDICINE

Type I interferons: crucial participants in disease amplification in autoimmunity

(2010) John C. Hall et al.   Nature Reviews Rheumatology

NCBI GEO: archive for functional genomics data sets--10 years on

(2010) T. Barrett et al.   NUCLEIC ACIDS RESEARCH

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project

(2010) M. B. Gerstein et al.   SCIENCE

MicroRNA-21 in Cardiovascular Disease

(2010) Yunhui Cheng et al.   Journal of Cardiovascular Translational Research

CHANGES IN microRNA (miR) PROFILE AND EFFECTS OF miR-320 IN INSULIN-RESISTANT 3T3-L1 ADIPOCYTES

(2009) Hong-Yan Ling et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Emerging Treatments in Cystic Fibrosis

(2009) Andrew M. Jones et al.   DRUGS

National Health Spending In 2007: Slower Drug Spending Contributes To Lowest Rate Of Overall Growth Since 1998

(2009) Micah Hartman et al.   HEALTH AFFAIRS

A census of human transcription factors: function, expression and evolution

(2009) Juan M. Vaquerizas et al.   NATURE REVIEWS GENETICS

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Dropping acid to help cystic fibrosis

(2008) Gerald B Pier   NATURE MEDICINE

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Novel agents in cystic fibrosis

(2008) Shane Storey et al.   NATURE REVIEWS DRUG DISCOVERY

Small non-coding RNAs in animal development

(2008) Giovanni Stefani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene Regulation by Transcription Factors and MicroRNAs

(2008) O. Hobert   SCIENCE