Computational drug repositioning through heterogeneous network clustering

Computational Drug Repositioning: From Data to Therapeutics

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DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data

(2012) Clare Pacini et al.   BIOINFORMATICS

Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug

(2012) Hee Lee et al.   BMC Systems Biology

Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome

(2012) Jean Y. Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recycling side-effects into clinical markers for drug repositioning

(2012) Miquel Duran-Frigola et al.   Genome Medicine

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

(2012) Feixiong Cheng et al.   PLoS Computational Biology

A SURVEY OF COMPUTATIONAL METHODS FOR PROTEIN COMPLEX PREDICTION FROM PROTEIN INTERACTION NETWORKS

(2012) SRIGANESH SRIHARI et al.   Journal of Bioinformatics and Computational Biology

The Orphan Disease Networks

(2011) Minlu Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Drug repositioning for orphan diseases

(2011) D. Sardana et al.   BRIEFINGS IN BIOINFORMATICS

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

Systematic Drug Repositioning Based on Clinical Side-Effects

(2011) Lun Yang et al.   PLoS One

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase and Human Disease

(2010) R. J. Kelleher et al.   SCIENCE

 -Secretase Gene Mutations in Familial Acne Inversa

(2010) B. Wang et al.   SCIENCE

Unveiling the role of network and systems biology in drug discovery

(2010) Albert Pujol et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

A γ-secretase inhibitor decreases amyloid-β production in the central nervous system

(2009) Randall J. Bateman et al.   ANNALS OF NEUROLOGY

Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses

(2009) A P Chiang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE