Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs)

Molecular Signatures of Amyotrophic Lateral Sclerosis Disease Progression in Hind and Forelimb Muscles of an SOD1G93A Mouse Model

(2012) Daniele Capitanio et al.   ANTIOXIDANTS & REDOX SIGNALING

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

(2012) Melissa Bowerman et al.   BMC Medicine

High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels

(2012) Taiga Ichinomiya et al.   Cardiovascular Diabetology

The Emerging Paradigm of Network Medicine in the Study of Human Disease

(2012) Stephen Y. Chan et al.   CIRCULATION RESEARCH

Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats

(2012) Sheng-jiang Guan et al.   FOOD AND CHEMICAL TOXICOLOGY

Network medicine: linking disorders

(2012) Rosario M. Piro   HUMAN GENETICS

Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases

(2012) Peter M. Clark et al.   INFLAMMATORY BOWEL DISEASES

Lipid mediators in plasma of autism spectrum disorders

(2012) Afaf El-Ansary et al.   Lipids in Health and Disease

Perspectives on the Development of Antioxidant Antiepileptogenic Agents

(2012) J. Rowles et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder

(2012) Andrew G. Foley et al.   NEUROPHARMACOLOGY

Drug repositioning for orphan diseases

(2011) D. Sardana et al.   BRIEFINGS IN BIOINFORMATICS

Role of neurosteroids in the anticonvulsant activity of midazolam

(2011) Ashish Dhir et al.   BRITISH JOURNAL OF PHARMACOLOGY

In silico repositioning of approved drugs for rare and neglected diseases

(2011) Sean Ekins et al.   DRUG DISCOVERY TODAY

An atlas of tissue-specific conserved coexpression for functional annotation and disease gene prediction

(2011) Rosario Michael Piro et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Preventive effects of fasudil on adriamycin-induced cardiomyopathy: Possible involvement of inhibition of RhoA/ROCK pathway

(2011) Na Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Drug repositioning: Re-investigating existing drugs for new therapeutic indications

(2011) BM Padhy et al.   Journal of Postgraduate Medicine

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

(2011) Daniel P. Reay et al.   NEUROBIOLOGY OF DISEASE

DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical–protein interactome

(2011) Heng Luo et al.   NUCLEIC ACIDS RESEARCH

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Identification of small molecules enhancing autophagic function from drug network analysis

(2010) Francesco Iorio et al.   Autophagy

Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development

(2010) F. Peter Guengerich   Drug Metabolism and Pharmacokinetics

Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

(2010) Y Tang et al.   GENE THERAPY

A comparative study of European rare disease and orphan drug markets

(2010) Alain Denis et al.   HEALTH POLICY

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

(2010) Jianjian Shi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Deciphering the Arabidopsis Floral Transition Process by Integrating a Protein-Protein Interaction Network and Gene Expression Data

(2010) F. He et al.   PLANT PHYSIOLOGY

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved co-expression for candidate disease gene prioritization

(2008) Martin Oti et al.   BMC BIOINFORMATICS

Gene module level analysis: identification to networks and dynamics

(2008) Xuewei Wang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Functional Annotation and Identification of Candidate Disease Genes by Computational Analysis of Normal Tissue Gene Expression Data

(2008) Laura Miozzi et al.   PLoS One

Prediction of Human Disease Genes by Human-Mouse Conserved Coexpression Analysis

(2008) Ugo Ala et al.   PLoS Computational Biology