Transgenerational epigenetic inheritance in mammals: how good is the evidence?

Aging and DNA methylation

(2015) Marc Jung et al.   BMC BIOLOGY

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

(2015) Walfred W.C. Tang et al.   CELL

Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats

(2015) Danielle Goodspeed et al.   FASEB JOURNAL

Environmental Epigenetics and a Unified Theory of the Molecular Aspects of Evolution: A Neo-Lamarckian Concept that Facilitates Neo-Darwinian Evolution

(2015) M. K. Skinner   Genome Biology and Evolution

DNA Methylation, Its Mediators and Genome Integrity

(2015) Huan Meng et al.   International Journal of Biological Sciences

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Integrative analysis of haplotype-resolved epigenomes across human tissues

(2015) Danny Leung et al.   NATURE

Maternal restraint stress during pregnancy in mice induces 11β-HSD1-associated metabolic changes in the livers of the offspring

(2015) H. Maeyama et al.   Journal of Developmental Origins of Health and Disease

Programming of stress-related behavior and epigenetic neural gene regulation in mice offspring through maternal exposure to predator odor

(2015) Sophie St-Cyr et al.   Frontiers in Behavioral Neuroscience

Change in paternal grandmothers´ early food supply influenced cardiovascular mortality of the female grandchildren

(2014) Lars Bygren et al.   BMC GENETICS

Programming and Inheritance of Parental DNA Methylomes in Mammals

(2014) Lu Wang et al.   CELL

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

(2014) Fan Guo et al.   Cell Stem Cell

DNA methylation abnormalities at gene promoters are extensive and variable in the elderly and phenocopy cancer cells

(2014) Hannah E. Gautrey et al.   FASEB JOURNAL

Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth

(2014) Akihiko Sakashita et al.   GENES TO CELLS

Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres

(2014) Shawn L. Chavez et al.   HUMAN MOLECULAR GENETICS

Maternal High Folic Acid Supplement Promotes Glucose Intolerance and Insulin Resistance in Male Mouse Offspring Fed a High-Fat Diet

(2014) Yifan Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dissecting neural differentiation regulatory networks through epigenetic footprinting

(2014) Michael J. Ziller et al.   NATURE

The DNA methylation landscape of human early embryos

(2014) Hongshan Guo et al.   NATURE

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

Genomic Imprinting in Mammals

(2014) D. P. Barlow et al.   Cold Spring Harbor Perspectives in Biology

Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications

(2014) Christine van de Werken et al.   Nature Communications

Genome-Wide Analysis of DNA Methylation Dynamics during Early Human Development

(2014) Hiroaki Okae et al.   PLoS Genetics

Sperm epigenomics: challenges and opportunities

(2014) Eduard Casas et al.   Frontiers in Genetics

Maternal western diet primes non-alcoholic fatty liver disease in adult mouse offspring

(2013) M. G. M. Pruis et al.   Acta Physiologica

Do age-related changes in DNA methylation play a role in the development of age-related diseases?

(2013) Sanne D. van Otterdijk et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

(2013) Nisha Padmanabhan et al.   CELL

Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline

(2013) James H. Crichton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parental smoking during pregnancy and risk of overweight and obesity in the daughter

(2013) H R Harris et al.   INTERNATIONAL JOURNAL OF OBESITY

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

Transgenerational epigenetic inheritance: how important is it?

(2013) Ueli Grossniklaus et al.   NATURE REVIEWS GENETICS

Fetal metabolic programming and epigenetic modifications: a systems biology approach

(2013) Silvia Sookoian et al.   PEDIATRIC RESEARCH

Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

(2013) Fátima Santos et al.   Epigenetics & Chromatin

Study of methylation of histone H3 lysine 9 and H3 lysine 27 during X chromosome inactivation in three types of cells

(2012) Yan Li et al.   CHROMOSOME RESEARCH

Genomic impact of cigarette smoke, with application to three smoking-related diseases

(2012) M. Talikka et al.   CRITICAL REVIEWS IN TOXICOLOGY

450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy

(2012) Bonnie R. Joubert et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

(2012) Emma L. Marczylo et al.   Epigenetics

Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence

(2012) L. Gordon et al.   GENOME RESEARCH

The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

(2012) Stefanie Seisenberger et al.   MOLECULAR CELL

A unique regulatory phase of DNA methylation in the early mammalian embryo

(2012) Zachary D. Smith et al.   NATURE

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers

(2012) S. Seisenberger et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Investigations on Transgenerational Epigenetic Response Down the Male Line in F2 Pigs

(2012) Martin Braunschweig et al.   PLoS One

Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes

(2012) Rasmus Ribel-Madsen et al.   PLoS One

Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine

(2012) J. A. Hackett et al.   SCIENCE

Genomic Imprinting and Epigenetic Control of Development

(2012) A. Fedoriw et al.   Cold Spring Harbor Perspectives in Biology

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

(2012) Jordana T. Bell et al.   PLoS Genetics

Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

(2011) Gregory A. Dunn et al.   ENDOCRINOLOGY

Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming

(2011) Lavinia Gordon et al.   Epigenetics

Zinc Finger Protein ZFP57 Requires Its Co-factor to Recruit DNA Methyltransferases and Maintains DNA Methylation Imprint in Embryonic Stem Cells via Its Transcriptional Repression Domain

(2011) Xiaopan Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hungry in the womb: What are the consequences? Lessons from the Dutch famine

(2011) Tessa J. Roseboom et al.   MATURITAS

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

(2011) Tian-Peng Gu et al.   NATURE

Non-coding RNAs as regulators of embryogenesis

(2011) Andrea Pauli et al.   NATURE REVIEWS GENETICS

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

(2011) Khursheed Iqbal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice

(2011) Cheryl C. Y. Li et al.   PLoS Genetics

Analysis of DNA Methylation in a Three-Generation Family Reveals Widespread Genetic Influence on Epigenetic Regulation

(2011) Jason Gertz et al.   PLoS Genetics

Epigenomics in Environmental Health

(2011) Brock C. Christensen et al.   Frontiers in Genetics

Tissue-specific dysregulation of DNA methylation in aging

(2010) Reid F. Thompson et al.   AGING CELL

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

(2010) Tim F. Oberlander et al.   Epigenetics

DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome

(2010) Miina Ollikainen et al.   HUMAN MOLECULAR GENETICS

Targets and dynamics of promoter DNA methylation during early mouse development

(2010) Julie Borgel et al.   NATURE GENETICS

Prenatal Exposure to apoE Deficiency and Postnatal Hypercholesterolemia Are Associated with Altered Cell-Specific Lysine Methyltransferase and Histone Methylation Patterns in the Vasculature

(2009) Fanneke E. Alkemade et al.   AMERICAN JOURNAL OF PATHOLOGY

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

(2008) Kay D. Wagner et al.   DEVELOPMENTAL CELL

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What is an epigenetic transgenerational phenotype?

(2007) Michael K. Skinner   REPRODUCTIVE TOXICOLOGY