Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease

Effect of CD47 Blockade on Vascular Inflammation

(2021) Kai-Uwe Jarr et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

(2020) Arif Yurdagul et al.   Cell Metabolism

Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα

(2020) Brandon H. Hayes et al.   JOURNAL OF CELL SCIENCE

Molecular mechanism of SHP2 activation by PD-1 stimulation

(2020) M. Marasco et al.   Science Advances

Metabolites released from apoptotic cells act as tissue messengers

(2020) Christopher B. Medina et al.   NATURE

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

(2020) Antoine Roquilly et al.   NATURE IMMUNOLOGY

CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis

(2020) Meghan A. Morrissey et al.   IMMUNITY

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

(2020) Ying Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition

(2020) Michal Caspi Tal et al.   mBio

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

(2020) Lu Cui et al.   Nature Communications

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

(2020) Darienne R. Myers et al.   Frontiers in Immunology

Revisiting the PD-1 pathway

(2020) Nikolaos Patsoukis et al.   Science Advances

LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation

(2019) Zi-ming Ye et al.   Cell Death & Disease

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

Signaling Regulatory Protein (SIRP)α-CD47 Blockade Joins the Ranks of Immune Checkpoint Inhibition

(2019) André Veillette et al.   JOURNAL OF CLINICAL ONCOLOGY

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Resolvin D1 promotes the targeting and clearance of necroptotic cells

(2019) Brennan D. Gerlach et al.   CELL DEATH AND DIFFERENTIATION

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Increased lymphocyte activation and atherosclerosis in CD47-deficient mice

(2019) Daniel Engelbertsen et al.   Scientific Reports

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

(2019) Claudia M. Rival et al.   Nature Communications

SHP-2 in Lymphocytes' Cytokine and Inhibitory Receptor Signaling

(2019) Charlène Niogret et al.   Frontiers in Immunology

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway

(2019) Justin S. A. Perry et al.   NATURE CELL BIOLOGY

Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages

(2018) Carolina P. Gomez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement

(2018) Spencer A. Freeman et al.   CELL

Origin and specialization of splenic macrophages

(2018) Noelia A-Gonzalez et al.   CELLULAR IMMUNOLOGY

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo

(2018) Giorgia Rota et al.   Cell Reports

Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis

(2018) Scott P. Davies et al.   Frontiers in Immunology

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma

(2018) Ranjana Advani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

(2017) Filipa B. Lopes et al.   JOURNAL OF CELL BIOLOGY

Shp1 function in myeloid cells

(2017) Clare L. Abram et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Unifying mechanism for different fibrotic diseases

(2017) Gerlinde Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

(2017) Paola A. Betancur et al.   Nature Communications

BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma

(2017) Fen Liu et al.   Oncotarget

Context-dependent compensation among phosphatidylserine-recognition receptors

(2017) Kristen K. Penberthy et al.   Scientific Reports

Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

(2016) L Tian et al.   CELL DEATH AND DIFFERENTIATION

The Dynamics of Apoptotic Cell Clearance

(2016) Michael R. Elliott et al.   DEVELOPMENTAL CELL

‘This way please’: Apoptotic cells regulate phagocyte migration before and after engulfment

(2016) Amiram Ariel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity

(2016) Clive S. Zent et al.   FEBS Journal

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo

(2016) Chang Sup Lee et al.   IMMUNITY

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

(2016) Michio Nakaya et al.   JOURNAL OF CLINICAL INVESTIGATION

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

(2016) Kipp Weiskopf et al.   JOURNAL OF CLINICAL INVESTIGATION

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation

(2016) Yuanyuan Ding et al.   NATURE IMMUNOLOGY

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Attenuation of the programmed cell death-1 pathway increases the M1 polarization of macrophages induced by zymosan

(2016) W Chen et al.   Cell Death & Disease

PD-1/PD-L pathway inhibits M.tb-specific CD4+ T-cell functions and phagocytosis of macrophages in active tuberculosis

(2016) Lei Shen et al.   Scientific Reports

PD-1 Blunts the Function of Ovarian Tumor–Infiltrating Dendritic Cells by Inactivating NF-κB

(2015) Lavakumar Karyampudi et al.   CANCER RESEARCH

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling

(2015) Andrew Getahun et al.   IMMUNOLOGICAL REVIEWS

Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages

(2015) Zhiyuan Lv et al.   JOURNAL OF IMMUNOLOGY

NF-κB Regulates PD-1 Expression in Macrophages

(2015) Alexander P. R. Bally et al.   JOURNAL OF IMMUNOLOGY

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

(2015) Huimin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System

(2015) Martin Guilliams et al.   Frontiers in Immunology

Polymorphism in the Innate Immune Receptor SIRPα Controls CD47 Binding and Autoimmunity in the Nonobese Diabetic Mouse

(2014) Andrea Sut Ling Wong et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis

(2014) Bo Tao et al.   JOURNAL OF IMMUNOLOGY

p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

(2014) Linjie Tian et al.   Nature Communications

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

The CD300 molecules: an emerging family of regulators of the immune system

(2013) F. Borrego   BLOOD

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction

(2013) Elaine Wan et al.   CIRCULATION RESEARCH

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

(2012) V. R. Simhadri et al.   BLOOD

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis

(2012) T. Kuriyama et al.   BLOOD

CD47 functions as a molecular switch for erythrocyte phagocytosis

(2012) P. Burger et al.   BLOOD

Regulation of the Inflammatory Response in Cardiac Repair

(2012) Nikolaos G. Frangogiannis   CIRCULATION RESEARCH

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor

(2012) Chigusa Nakahashi-Oda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Susceptibility to Salmonella Infection in Signal Regulatory Protein  -Deficient Mice

(2012) L.-X. Li et al.   JOURNAL OF IMMUNOLOGY

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor

(2011) Chigusa Nakahashi-Oda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The CD47 pathway is deregulated in human immune thrombocytopenia

(2011) Lucia Catani et al.   EXPERIMENTAL HEMATOLOGY

CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines

(2011) Eun-Ju Kim et al.   IMMUNOLOGY

An essential role for the association of CD47 to SHPS-1 in skeletal remodeling

(2011) Laura A Maile et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cutting Edge: Mouse CD300f (CMRF-35-Like Molecule-1) Recognizes Outer Membrane-Exposed Phosphatidylserine and Can Promote Phagocytosis

(2011) S.-C. Choi et al.   JOURNAL OF IMMUNOLOGY

Signal Regulatory Protein   Regulates the Homeostasis of T Lymphocytes in the Spleen

(2011) M. Sato-Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

(2011) Nicolas Legrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation by SIRP  of dendritic cell homeostasis in lymphoid tissues

(2010) Y. Saito et al.   BLOOD

CD47 promotes both phosphatidylserine-independent and phosphatidylserine-dependent phagocytosis of apoptotic murine thymocytes by non-activated macrophages

(2009) Anna Nilsson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

Functions and molecular mechanisms of the CD47–SIRPα signalling pathway

(2009) Takashi Matozaki et al.   TRENDS IN CELL BIOLOGY

Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα

(2008) William J. Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future

(2008) Marc Daëron et al.   IMMUNOLOGICAL REVIEWS

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

(2008) Richard K. Tsai et al.   JOURNAL OF CELL BIOLOGY

Refinement of the retinogeniculate pathway

(2008) William Guido   JOURNAL OF PHYSIOLOGY-LONDON

The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcγRIIa) mediated signaling

(2007) Yelina Alvarez et al.   MOLECULAR IMMUNOLOGY