Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα

(2020) Brandon H. Hayes et al.   JOURNAL OF CELL SCIENCE

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

(2020) Alyssa M. Flores et al.   Nature Nanotechnology

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

Biobanking: Objectives, Requirements, and Future Challenges—Experiences from the Munich Vascular Biobank

(2019) Jaroslav Pelisek et al.   Journal of Clinical Medicine

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

(2018) Ashish Misra et al.   Nature Communications

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma

(2018) Ranjana Advani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

(2018) Lina Dobnikar et al.   Nature Communications

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

(2018) Vivek Nanda et al.   PLoS Genetics

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

(2017) Paola A. Betancur et al.   Nature Communications

Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4Novelty and Significance

(2016) Mark W. Majesky et al.   CIRCULATION RESEARCH

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

The versatile functions of complement C3-derived ligands

(2016) Anna Erdei et al.   IMMUNOLOGICAL REVIEWS

Complement in removal of the dead - balancing inflammation

(2016) Myriam Martin et al.   IMMUNOLOGICAL REVIEWS

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases

(2016) O. Franzen et al.   SCIENCE

CDKN2B Regulates TGF β Signaling and Smooth Muscle Cell Investment of Hypoxic NeovesselsNovelty and Significance

(2015) Vivek Nanda et al.   CIRCULATION RESEARCH

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

(2014) Susanne Feil et al.   CIRCULATION RESEARCH

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

(2014) Yoko Kojima et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct associations of complement C3a and its precursor C3 with atherosclerosis and cardiovascular disease

(2014) Marleen M. van Greevenbroek et al.   THROMBOSIS AND HAEMOSTASIS

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Detection of histone modifications at specific gene loci in single cells in histological sections

(2013) Delphine Gomez et al.   NATURE METHODS

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE