Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

(2020) Russell P. Swift et al.   PLoS Pathogens

Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum

(2020) Krithika Rajaram et al.   mSphere

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

(2020) Russell P Swift et al.   eLife

Development of a conditional localization approach to control apicoplast protein trafficking in malaria parasites

(2019) Aleah D. Roberts et al.   TRAFFIC

Antimalarial pantothenamide metabolites target acetyl–coenzyme A biosynthesis in Plasmodium falciparum

(2019) Joost Schalkwijk et al.   Science Translational Medicine

Host biotin is required for liver stage development in malaria parasites

(2018) Teegan A. Dellibovi-Ragheb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncovering the essential genes of the human malaria parasitePlasmodium falciparumby saturation mutagenesis

(2018) Min Zhang et al.   SCIENCE

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

(2018) Erick T. Tjhin et al.   PLoS Pathogens

The Plasmodium falciparum male gametocyte protein P230p, a paralog of P230, is vital for ookinete formation and mosquito transmission

(2018) Catherin Marin-Mogollon et al.   Scientific Reports

PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum

(2017) Anat Florentin et al.   Cell Reports

Genetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito

(2017) Robert J. Hart et al.   Frontiers in Cellular and Infection Microbiology

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

(2016) Sabine Fletcher et al.   Parasites & Vectors

Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite

(2016) Sanketha Kenthirapalan et al.   Nature Communications

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

(2016) Anubhav Srivastava et al.   PLoS Pathogens

A Putative Small Solute Transporter Is Responsible for the Secretion of G377 and TRAP-Containing Secretory Vesicles during Plasmodium Gamete Egress and Sporozoite Motility

(2016) Jessica Kehrer et al.   PLoS Pathogens

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

(2016) Charisse Flerida A. Pasaje et al.   Scientific Reports

Genetic Characterization of Plasmodium Putative Pantothenate Kinase Genes Reveals Their Essential Role in Malaria Parasite Transmission to the Mosquito

(2016) Robert J. Hart et al.   Scientific Reports

A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity

(2015) Cristiano J. Macuamule et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts

(2015) Melanie J. Shears et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites

(2015) Frank Schwach et al.   NUCLEIC ACIDS RESEARCH

Isoprenoid Biosynthesis in Plasmodium falciparum

(2014) Ann M. Guggisberg et al.   EUKARYOTIC CELL

A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

(2014) Sabine Fletcher et al.   MALARIA JOURNAL

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Versatile control of Plasmodium falciparum gene expression with an inducible protein–RNA interaction

(2014) Stephen J. Goldfless et al.   Nature Communications

Plasmodium yoelii Vitamin B5 Pantothenate Transporter Candidate is Essential for Parasite Transmission to the Mosquito

(2014) Robert J. Hart et al.   Scientific Reports

Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

(2013) Jessica D. Bowman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Type II Fatty Acid Biosynthesis Is Essential for Plasmodium falciparum Sporozoite Development in the Midgut of Anopheles Mosquitoes

(2013) Ben C. L. van Schaijk et al.   EUKARYOTIC CELL

Identification and Functional Analysis of the Primary Pantothenate Transporter, PfPAT, of the Human Malaria ParasitePlasmodium falciparum

(2013) Yoann Augagneur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

(2013) Christina Spry et al.   PLoS One

The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites

(2013) Jolyn E. Gisselberg et al.   PLoS Pathogens

Plasmodium falciparum Apicoplast Transit Peptides are Unstructured in vitro and During Apicoplast Import

(2011) John R. Gallagher et al.   TRAFFIC

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY

Phosphatidylinositol 3-Monophosphate Is Involved in Toxoplasma Apicoplast Biogenesis

(2011) Lina Tawk et al.   PLoS Pathogens

Validation of a modified method for Bxb1 mycobacteriophage integrase-mediated recombination in Plasmodium falciparum by localization of the H-protein of the glycine cleavage complex to the mitochondrion

(2010) Maroya D. Spalding et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Plasmodiumpyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection

(2010) Ying Pei et al.   MOLECULAR MICROBIOLOGY

The Human Malaria ParasitePlasmodium falciparumIs Not Dependent on Host Coenzyme A Biosynthesis

(2009) Christina Spry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmodium falciparumacyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth

(2009) John R. Gallagher et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Malaria Pulls a FASt One

(2008) Maroya D. Spalding et al.   Cell Host & Microbe

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

(2008) Min Yu et al.   Cell Host & Microbe

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

A regulatable transgene expression system for cultured Plasmodium falciparum parasites

(2008) Christian Epp et al.   MALARIA JOURNAL