Antimalarial pantothenamide metabolites target acetyl–coenzyme A biosynthesis in Plasmodium falciparum

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

(2018) Erick T. Tjhin et al.   PLoS Pathogens

New developments in anti-malarial target candidate and product profiles

(2017) Jeremy N. Burrows et al.   MALARIA JOURNAL

The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation

(2017) Joy E. Chiu et al.   Scientific Reports

Genetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito

(2017) Robert J. Hart et al.   Frontiers in Cellular and Infection Microbiology

Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target

(2017) Marianne de Villiers et al.   ACS Infectious Diseases

Triazole substitution of a labile amide bond stabilizes pantothenamides and improves their antiplasmodial potency

(2016) Vanessa M. Howieson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

(2016) Erik L. Allman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A cross-metathesis approach to novel pantothenamide derivatives

(2016) Jinming Guan et al.   Beilstein Journal of Organic Chemistry

Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail

(2016) Alexander Boes et al.   MALARIA JOURNAL

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

(2016) Sabine Fletcher et al.   Parasites & Vectors

Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite

(2016) Sanketha Kenthirapalan et al.   Nature Communications

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

(2016) Michelle Yi-Xiu Lim et al.   Nature Microbiology

A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity

(2015) Cristiano J. Macuamule et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugs

(2015) J. M. Bolscher et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel pantothenate derivatives for anti-malarial chemotherapy

(2015) Helmi E Pett et al.   MALARIA JOURNAL

An improved SYBR Green-1-based fluorescence method for the routine monitoring of Plasmodium falciparum resistance to anti-malarial drugs

(2015) Victor Dery et al.   MALARIA JOURNAL

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

(2015) Margaret A. Phillips et al.   Science Translational Medicine

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities

(2015) Serena Pulcini et al.   Scientific Reports

A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes

(2015) Martijn W. Vos et al.   Scientific Reports

Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

(2014) Annabelle Hoegl et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Plasmodium yoelii Vitamin B5 Pantothenate Transporter Candidate is Essential for Parasite Transmission to the Mosquito

(2014) Robert J. Hart et al.   Scientific Reports

Combination of Pantothenamides with Vanin Inhibitors as a Novel Antibiotic Strategy against Gram-Positive Bacteria

(2013) Patrick A. M. Jansen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization

(2013) Nicholas J. White   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kinetic Flux Profiling Elucidates Two Independent Acetyl-CoA Biosynthetic Pathways inPlasmodium falciparum

(2013) Simon A. Cobbold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

(2013) Christina Spry et al.   PLoS One

Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity

(2013) Marianne de Villiers et al.   ACS Medicinal Chemistry Letters

Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

(2013) Selina E. R. Bopp et al.   PLoS Genetics

Discovery of Small Molecule Vanin Inhibitors: New Tools To Study Metabolism and Disease

(2012) Patrick A. M. Jansen et al.   ACS Chemical Biology

Metabolomic Analysis via Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to a Stand Alone Orbitrap Mass Spectrometer

(2010) Wenyun Lu et al.   ANALYTICAL CHEMISTRY

Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2R null Mice Engrafted with Human Erythrocytes

(2009) M. B. Jimenez-Diaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Human Malaria ParasitePlasmodium falciparumIs Not Dependent on Host Coenzyme A Biosynthesis

(2009) Christina Spry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Red Blood Cell Proteome and Interactome: An Update

(2009) Angelo D’Alessandro et al.   JOURNAL OF PROTEOME RESEARCH