Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity

(2015) Cristiano J. Macuamule et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial ATP synthase is dispensable in blood-stagePlasmodium bergheirodent malaria but essential in the mosquito phase

(2015) Angelika Sturm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle

(2015) Hangjun Ke et al.   Cell Reports

Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites

(2015) Anubhav Srivastava et al.   PLoS Pathogens

Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides

(2014) Kevin J. Saliba et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A comprehensive evaluation of rodent malaria parasite genomes and gene expression

(2014) Thomas D Otto et al.   BMC BIOLOGY

Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility

(2014) Arthur M Talman et al.   MALARIA JOURNAL

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

(2014) Abhinav Sinha et al.   NATURE

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development

(2014) J. Enrique Salcedo-Sora et al.   TRENDS IN PARASITOLOGY

Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism

(2014) Janet Storm et al.   PLoS Pathogens

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

(2014) Rebecca D. Oppenheim et al.   PLoS Pathogens

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

(2013) James I MacRae et al.   BMC BIOLOGY

Fatty Acid Labeling from Glutamine in Hypoxia Can Be Explained by Isotope Exchange without Net Reductive Isocitrate Dehydrogenase (IDH) Flux

(2013) Jing Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

(2013) Christina Spry et al.   PLoS One

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii

(2012) James I. MacRae et al.   Cell Host & Microbe

Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei

(2012) A. Hino et al.   JOURNAL OF BIOCHEMISTRY

Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2

(2012) Kathleen Zocher et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Use of a Selective Inhibitor To Define the Chemotherapeutic Potential of the Plasmodial Hexose Transporter in Different Stages of the Parasite's Life Cycle

(2011) Ksenija Slavic et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Arrested Oocyst Maturation inPlasmodiumParasites Lacking Type II NADH:Ubiquinone Dehydrogenase

(2011) Katja E. Boysen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isotopomer Profiling ofLeishmania mexicanaPromastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth

(2011) Eleanor C. Saunders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

(2011) Janet Storm et al.   MALARIA JOURNAL

Central carbon metabolism of Plasmodium parasites

(2010) Kellen L. Olszewski et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Life cycle studies of the hexose transporter ofPlasmodiumspecies and genetic validation of their essentiality

(2010) Ksenija Slavic et al.   MOLECULAR MICROBIOLOGY

The evolution, metabolism and functions of the apicoplast

(2010) L. Lim et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Human Malaria ParasitePlasmodium falciparumIs Not Dependent on Host Coenzyme A Biosynthesis

(2009) Christina Spry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redefining the role of de novo fatty acid synthesis in Plasmodium parasites

(2009) Alice S. Tarun et al.   TRENDS IN PARASITOLOGY

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

(2008) Min Yu et al.   Cell Host & Microbe

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

Apicoplast and Mitochondrion in Gametocytogenesis ofPlasmodium falciparum

(2008) Noriko Okamoto et al.   EUKARYOTIC CELL

Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast

(2008) Takuya Maeda et al.   PARASITOLOGY INTERNATIONAL