Modulation of serine/threonine-protein phosphatase 1 (PP1) complexes: A promising approach in cancer treatment

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer

(2020) Andreas Marx et al.   DISEASE MARKERS

Spotlight on AKT: Current Therapeutic Challenges

(2020) Ina Landel et al.   ACS Medicinal Chemistry Letters

Turn and Face the Strange: A New View on Phosphatases

(2020) Maja Köhn   ACS Central Science

Identification of peptides interfering with the LRRK2/PP1 interaction

(2020) Chang Zhi Dong et al.   PLoS One

Protein phosphatase 1 in tumorigenesis: is it worth a closer look?

(2020) Juliana Felgueiras et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Estrogen induced apoptosis in breast cancers is phenocopied by blocking dephosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) protein.

(2019) Surojeet Sengupta et al.   MOLECULAR CANCER RESEARCH

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells

(2019) Peiying Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells

(2019) Cholpon S. Djuzenova et al.   BMC CANCER

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

(2019) Jin Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Akt in cancer: Mediator and more

(2019) Sundaramoorthy Revathidevi et al.   SEMINARS IN CANCER BIOLOGY

SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

(2019) Greg G. Jones et al.   Nature Communications

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

(2019) Kerrie-Ann McMahon et al.   Nature Communications

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

(2019) Xionghao Lin et al.   Frontiers in Microbiology

Development of a Photoactivatable Protein Phosphatase-1-Disrupting Peptide

(2019) Malgorzata Trebacz et al.   JOURNAL OF ORGANIC CHEMISTRY

Interfering peptides targeting protein–protein interactions: the next generation of drugs?

(2018) Heriberto Bruzzoni-Giovanelli et al.   DRUG DISCOVERY TODAY

Kinase-targeted cancer therapies: progress, challenges and future directions

(2018) Khushwant S. Bhullar et al.   Molecular Cancer

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

(2018) Ming Chen et al.   Nature Communications

PP1 Phosphatase Complexes: Undruggable No Longer

(2018) Paola Vagnarelli et al.   CELL

Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer

(2018) Nathaniel W. Mabe et al.   JOURNAL OF CLINICAL INVESTIGATION

α7nAChR-mediated recruitment of PP1γ promotes TRAF6/NF-κB cascade to facilitate the progression of Hepatocellular Carcinoma

(2018) Chunhua Wan et al.   MOLECULAR CARCINOGENESIS

Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer

(2018) Deeksha Pal et al.   Cell Death & Disease

RIF1 promotes tumor growth and cancer stem cell-like traits in NSCLC by protein phosphatase 1-mediated activation of Wnt/β-catenin signaling

(2018) Ying Mei et al.   Cell Death & Disease

Protease-activated receptor 2 signaling modulates susceptibility of colonic epithelium to injury through stabilization of YAP in vivo

(2018) Longmei He et al.   Cell Death & Disease

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

(2018) Dharmendra Dingar et al.   Nature Communications

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway

(2018) Debasish Paul et al.   NEOPLASIA

Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells

(2017) Huihui Li et al.   GASTROENTEROLOGY

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity

(2017) Joana Branco-Santos et al.   HUMAN MOLECULAR GENETICS

Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells

(2017) Pui-Kei Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis

(2017) W Luo et al.   ONCOGENE

OCT4 controls mitotic stability and inactivates the RB tumor suppressor pathway to enhance ovarian cancer aggressiveness

(2017) E Comisso et al.   ONCOGENE

Phosphorylation: Implications in Cancer

(2017) Vishakha Singh et al.   PROTEIN JOURNAL

Overexpression of cofilin correlates with poor survival in breast cancer: A tissue microarray analysis

(2017) Yusufu Maimaiti et al.   Oncology Letters

PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

(2017) Tao Chen et al.   Nature Communications

Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

(2017) Monika Haemmerle et al.   Nature Communications

Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer

(2017) Eva M. Verdugo-Sivianes et al.   Oncotarget

Differential regulation of the androgen receptor by protein phosphatase regulatory subunits

(2017) James Grey et al.   Oncotarget

Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells

(2017) Adrienn Sipos et al.   Scientific Reports

GADD34 Promotes Tumor Growth by Inducing Myeloid-derived Suppressor Cells

(2016) LINTAO LIU et al.   ANTICANCER RESEARCH

Is There a Future for AKT Inhibitors in the Treatment of Cancer?

(2016) V. M. Jansen et al.   CLINICAL CANCER RESEARCH

Current Challenges in Cancer Treatment

(2016) Jon Zugazagoitia et al.   CLINICAL THERAPEUTICS

Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome

(2016) David Y. Chiang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response

(2016) David W. Reid et al.   MOLECULAR AND CELLULAR BIOLOGY

Androgen ablation elicits PP1-dependence for AR stabilization and transactivation in prostate cancer

(2016) Xiaming Liu et al.   PROSTATE

Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target

(2016) André Steven et al.   Oncotarget

Liposomal C6 Ceramide Activates Protein Phosphatase 1 to Inhibit Melanoma Cells

(2016) Fangzhen Jiang et al.   PLoS One

Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells

(2015) Wanyeon Kim et al.   APOPTOSIS

Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice

(2015) Yuriko Tanaka et al.   BRITISH JOURNAL OF CANCER

Phase I trial of valproic acid and lenalidomide in patients with advanced cancer

(2015) Mehmet Asim Bilen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

An oncologist׳s friend: How Xenopus contributes to cancer research

(2015) Laura J.A. Hardwick et al.   DEVELOPMENTAL BIOLOGY

Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma

(2015) Paul G Richardson et al.   Expert Review of Anticancer Therapy

Alterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation Patients

(2015) David Y. Chiang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors

(2015) I Ferrer et al.   ONCOGENE

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α

(2015) Margarito Rojas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC

(2015) Zi Wang et al.   Oncotarget

Progesterone and Src Family Inhibitor PP1 Synergistically Inhibit Cell Migration and Invasion of Human Basal Phenotype Breast Cancer Cells

(2015) Mingxuan Xie et al.   Biomed Research International

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Phase I First-in-Human Study of CUDC-101, a Multitargeted Inhibitor of HDACs, EGFR, and HER2 in Patients with Advanced Solid Tumors

(2014) T. Shimizu et al.   CLINICAL CANCER RESEARCH

Protein Phosphatase 1 and Its Complexes in Carcinogenesis

(2014) Joao Figueiredo et al.   CURRENT CANCER DRUG TARGETS

HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis

(2014) Manjola Balliu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells

(2013) Masumi Eto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Does phosphorylation of cofilin affect the progression of human bladder cancer?

(2013) Hong Chung et al.   BMC CANCER

OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2

(2013) N Winston West et al.   BMC CANCER

JNK signalling in cancer: in need of new, smarter therapeutic targets

(2013) Concetta Bubici et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway

(2013) Guo-bing Li et al.   Cell Communication and Signaling

Spinophilin Loss Correlates with Poor Patient Prognosis in Advanced Stages of Colon Carcinoma

(2013) P. Estevez-Garcia et al.   CLINICAL CANCER RESEARCH

A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors

(2013) B. Venugopal et al.   CLINICAL CANCER RESEARCH

Histone Deacetylases

(2013) Sabnam Parbin et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Overexpression of CDCA2 in Human Squamous Cell Carcinoma: Correlation with Prevention of G1 Phase Arrest and Apoptosis

(2013) Fumihiko Uchida et al.   PLoS One

The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation

(2013) Mei-Jen Chuang et al.   PLoS One

STOP gene Phactr4 is a tumor suppressor

(2013) N. L. Solimini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of STAT3 in Cancer Metastasis and Translational Advances

(2013) Mohammad Zahid Kamran et al.   Biomed Research International

Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Zoledronic acid in combination with serine/threonine phosphatase inhibitors induces enhanced cytotoxicity and apoptosis in hormone-refractory prostate cancer cell lines by decreasing the activities of PP1 and PP2A

(2012) Yalcin Cirak et al.   BJU INTERNATIONAL

PNUTS Functions as a Proto-Oncogene by Sequestering PTEN

(2012) S. Kavela et al.   CANCER RESEARCH

An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction

(2012) Anja Richter et al.   CHEMISTRY-A EUROPEAN JOURNAL

SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator

(2012) Gang Ma et al.   International Journal of Biological Sciences

Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas

(2012) Soo Kee Min et al.   Korean Journal of Pathology

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

(2012) Jerina Boelens et al.   LEUKEMIA RESEARCH

Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro

(2012) Chen Yao et al.   Molecular Oncology

Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK

(2012) Yu-yi Lin et al.   NATURE

Protein Phosphatase 1α Interacting Proteins in the Human Brain

(2012) Sara L.C. Esteves et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Heart Failure-Inducible Gene Therapy Targeting Protein Phosphatase 1 Prevents Progressive Left Ventricular Remodeling

(2012) Yosuke Miyazaki et al.   PLoS One

Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1

(2012) Tatiana Ammosova et al.   PLoS One

A Role for PP1/NIPP1 in Steering Migration of Human Cancer Cells

(2012) Cristina Martin-Granados et al.   PLoS One

Phthalates Stimulate the Epithelial to Mesenchymal TransitionThrough an HDAC6-Dependent Mechanism in Human BreastEpithelial Stem Cells

(2012) Tsung-Hua Hsieh et al.   TOXICOLOGICAL SCIENCES

Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels

(2012) Miao Zhang et al.   Nature Communications

IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor growth and progression of cervical carcinoma cells by inducing G2/M arrest

(2012) Qiyan Zeng et al.   Cancer Genetics

Identification of the human testis protein phosphatase 1 interactome

(2011) Margarida Fardilha et al.   BIOCHEMICAL PHARMACOLOGY

Disruption of the PP1/GADD34 complex induces calreticulin exposure

(2011) Oliver Kepp et al.   CELL CYCLE

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions

(2011) Kyoung Min Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells

(2011) Faisal Thayyullathil et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Unfolded protein response in cancer: the Physician's perspective

(2011) Xuemei Li et al.   Journal of Hematology & Oncology

Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility

(2011) M. Fardilha et al.   MOLECULAR HUMAN REPRODUCTION

Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling

(2011) Y Jiang et al.   ONCOGENE

PP1A-Mediated Dephosphorylation Positively Regulates YAP2 Activity

(2011) Pei Wang et al.   PLoS One

Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC

(2011) Karl Quint et al.   VIRCHOWS ARCHIV

C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo

(2011) Q-y Zhu et al.   Cell Death & Disease

Identification and Structure of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions

(2010) Rolf Rose et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation

(2010) L Xiao et al.   CELL DEATH AND DIFFERENTIATION

Repo-Man Controls a Protein Phosphatase 1-Dependent Threshold for DNA Damage Checkpoint Activation

(2010) Aimin Peng et al.   CURRENT BIOLOGY

Targeting Protein Tyrosine Phosphatases for Anticancer Drug Discovery

(2010) Latanya M. Scott et al.   CURRENT PHARMACEUTICAL DESIGN

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

(2010) Roel H Wilting et al.   EMBO JOURNAL

Nonhistone protein acetylation as cancer therapy targets

(2010) Brahma N Singh et al.   Expert Review of Anticancer Therapy

Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin

(2010) Akiko Hayashi et al.   INTERNATIONAL JOURNAL OF CANCER

PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1α

(2010) Iris Eke et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive Analysis of Phosphorylation Sites in Tensin1 Reveals Regulation by p38MAPK

(2010) Emily H. Hall et al.   MOLECULAR & CELLULAR PROTEOMICS

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2

(2010) W-W Lei et al.   Cell Death & Disease

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

(2009) M. Gupta et al.   BLOOD

Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells

(2009) Maiko Suzuki et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

(2009) Giovanni Di Maira et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1

(2009) Annick Hendrickx et al.   CHEMISTRY & BIOLOGY

Tensin1 Requires Protein Phosphatase-1α in Addition to RhoGAP DLC-1 to Control Cell Polarization, Migration, and Invasion

(2009) Emily H. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen Receptor Phosphorylation and Activity Are Regulated by an Association with Protein Phosphatase 1

(2009) Shaoyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner

(2009) Christian Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anticancer activity of targeted proapoptotic peptides and chemotherapy is highly improved by targeted cell surface calreticulin-inducer peptides

(2009) M. Obeid   MOLECULAR CANCER THERAPEUTICS

Targeting Protein Serine/Threonine Phosphatases for Drug Development

(2009) J. L. McConnell et al.   MOLECULAR PHARMACOLOGY

Inhibition of histone deacetylase1 induces autophagy

(2008) Meeyeon Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDAC expression and clinical prognosis in human malignancies

(2008) Wilko Weichert   CANCER LETTERS

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Expression of Aurora kinase A and B in normal and malignant cervical tissue: High Aurora A kinase expression in squamous cervical cancer

(2008) Nae-Fang Twu et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Unlocking Repression of the Human Luteinizing Hormone Receptor Gene by Trichostatin A-induced Cell-specific Phosphatase Release

(2008) Ying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors

(2008) Matthew S. Kelker et al.   JOURNAL OF MOLECULAR BIOLOGY

Essential Phosphatases and a Phospho-Degron Are Critical for Regulation of SRC-3/AIB1 Coactivator Function and Turnover

(2008) Chao Li et al.   MOLECULAR CELL

Caveolin-1-Mediated Expression and Secretion of Kallikrein 6 in Colon Cancer Cells

(2008) Rebecca S. Henkhaus et al.   NEOPLASIA