Histone Deacetylases

Elucidating the Mechanism of Regulation of Transforming Growth Factor β Type II Receptor Expression in Human Lung Cancer Cell Lines

(2015) Sunil K. Halder et al.   NEOPLASIA

HDAC6 Deacetylates Ku70 and Regulates Ku70-Bax Binding in Neuroblastoma

(2015) Chitra Subramanian et al.   NEOPLASIA

Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma

(2013) N Nohata et al.   BRITISH JOURNAL OF CANCER

HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity

(2013) Gang Ding et al.   FEBS LETTERS

Epigenetic silencing of Bcl-2, CEBPA and p14ARF by the AML1-ETO oncoprotein contributing to growth arrest and differentiation block in the U937 cell line

(2013) WEN-YUE ZHUANG et al.   ONCOLOGY REPORTS

SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity

(2012) Yoshiaki Mizuguchi et al.   BMC MOLECULAR BIOLOGY

Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically

(2012) Michal Zapotocky et al.   CANCER LETTERS

Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing Family Tumors

(2012) Yan Li et al.   CANCER LETTERS

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

(2012) E Kerr et al.   CELL DEATH AND DIFFERENTIATION

HDAC5 is required for maintenance of pericentric heterochromatin and controls cell-cycle progression and survival of human cancer cells

(2012) P Peixoto et al.   CELL DEATH AND DIFFERENTIATION

Acetylation modulates the STAT signaling code

(2012) Martin Wieczorek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins

(2012) Kwang Hwa Jung et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells

(2012) F-C Lin et al.   ONCOGENE

HDAC1 Inactivation Induces Mitotic Defect and Caspase-Independent Autophagic Cell Death in Liver Cancer

(2012) Hong Jian Xie et al.   PLoS One

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL

(2011) Vitaliy O. Kaminskyy et al.   CARCINOGENESIS

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

(2011) Ali Aghdassi et al.   GUT

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

(2011) L. Dan et al.   HAEMATOLOGICA

HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia

(2011) Hao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer

(2011) Hyo Sung Jeon et al.   LUNG CANCER

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

(2011) A. Menssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

(2011) Praveen Rajendran et al.   Clinical Epigenetics

Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion

(2010) Nam Hyun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

Anticancer Therapy SMRT-ens Up: Targeting the BCL6-SMRT Interaction in B Cell Lymphoma

(2010) Leigh A. Compton et al.   CANCER CELL

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

A Novel Epigenetic Phenotype Associated With the Most Aggressive Pathway of Bladder Tumor Progression

(2010) Céline Vallot et al.   JNCI-Journal of the National Cancer Institute

Combined proteasome and histone deacetylase inhibition attenuates epithelial–mesenchymal transition through E-cadherin in esophageal cancer cells

(2010) Matthew D. Taylor et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells

(2010) Susanne Schuler et al.   Molecular Cancer

MS-275 Sensitizes TRAIL-Resistant Breast Cancer Cells, Inhibits Angiogenesis and Metastasis, and Reverses Epithelial-Mesenchymal Transition In vivo

(2010) R. K. Srivastava et al.   MOLECULAR CANCER THERAPEUTICS

Acetylation modulates prolactin receptor dimerization

(2010) L. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular marks for epigenetic identification of developmental and cancer stem cells

(2010) Samir Kumar Patra et al.   Clinical Epigenetics

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

(2009) Nanda Burger-van Paassen et al.   BIOCHEMICAL JOURNAL

The expression and significance of HIF-1α and GLUT-3 in glioma

(2009) Yang Liu et al.   BRAIN RESEARCH

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

(2009) Johannes von Burstin et al.   GASTROENTEROLOGY

Claudin-1 Has Tumor Suppressive Activity and Is a Direct Target of RUNX3 in Gastric Epithelial Cells

(2009) Ti Ling Chang et al.   GASTROENTEROLOGY

HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA

(2009) P Fritsche et al.   GUT

Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL

(2009) Dolly G. Aguilera et al.   JOURNAL OF NEURO-ONCOLOGY

The Cyclin-Dependent Kinase Inhibitor p21 Is a Crucial Target for Histone Deacetylase 1 as a Regulator of Cellular Proliferation

(2009) G. Zupkovitz et al.   MOLECULAR AND CELLULAR BIOLOGY

Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice

(2009) S. Shankar et al.   MOLECULAR CANCER THERAPEUTICS

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

(2009) E J Noonan et al.   ONCOGENE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Chemical mechanisms of histone lysine and arginine modifications

(2008) Brian C. Smith et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells

(2008) R. Rao et al.   BLOOD

Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

(2008) W Weichert et al.   BRITISH JOURNAL OF CANCER

RUNX3 Attenuates β-Catenin/T Cell Factors in Intestinal Tumorigenesis

(2008) Kosei Ito et al.   CANCER CELL

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Repression of 15-Hydroxyprostaglandin Dehydrogenase Involves Histone Deacetylase 2 and Snail in Colorectal Cancer

(2008) M. G. Backlund et al.   CANCER RESEARCH

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

(2008) I. Oehme et al.   CLINICAL CANCER RESEARCH

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

Competitive or noncompetitive, that's the question: research toward histone deacetylase inhibitors

(2008) H. Su et al.   MOLECULAR CANCER THERAPEUTICS

Epigenetic interplay between histone modifications and DNA methylation in gene silencing

(2008) T VAISSIERE et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

(2008) D Mottet et al.   ONCOGENE

HDAC3 overexpression and colon cancer cell proliferation and differentiation

(2007) Colleen C. Spurling et al.   MOLECULAR CARCINOGENESIS