Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci

TopBP1 assembles nuclear condensates to switch on ATR signaling

(2021) Camilla Frattini et al.   MOLECULAR CELL

A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage

(2021) Chao Dong et al.   NUCLEIC ACIDS RESEARCH

RNA transcripts stimulate homologous recombination by forming DR-loops

(2021) Jian Ouyang et al.   NATURE

R-loops as Janus-faced modulators of DNA repair

(2021) Aline Marnef et al.   NATURE CELL BIOLOGY

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

(2020) Clémence Mooser et al.   Nature Communications

Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin

(2020) Chao Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ

(2020) Chance Meers et al.   MOLECULAR CELL

Hedgehog signaling enables repair of ribosomal DNA double-strand breaks

(2020) Tshering D Lama-Sherpa et al.   NUCLEIC ACIDS RESEARCH

Single-molecule imaging of transcription at damaged chromatin

(2019) Alexandra C. Vítor et al.   Science Advances

Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks

(2019) Kaspar Burger et al.   NUCLEIC ACIDS RESEARCH

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks

(2019) Pierre Caron et al.   GENES & DEVELOPMENT

Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?

(2019) Nadine Puget et al.   DNA REPAIR

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

(2019) Lea M Korsholm et al.   NUCLEIC ACIDS RESEARCH

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks

(2019) Judit Domingo-Prim et al.   Nature Communications

A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair

(2019) Aline Marnef et al.   GENES & DEVELOPMENT

Bon voyage: A transcriptional journey around DNA breaks

(2019) Pierre Caron et al.   DNA REPAIR

MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B

(2018) Dafni Eleftheria Pefani et al.   EMBO JOURNAL

How cells ensure correct repair of DNA double-strand breaks

(2018) Joonyoung Her et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

(2018) Sarah Cohen et al.   Nature Communications

Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

(2018) Takaaki Yasuhara et al.   CELL

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability

(2018) Cornelia Meisenberg et al.   MOLECULAR CELL

Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks

(2018) Franziska Bonath et al.   NUCLEIC ACIDS RESEARCH

BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

(2018) Giuseppina D’Alessandro et al.   Nature Communications

Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair

(2017) Fade Gong et al.   JOURNAL OF CELL BIOLOGY

Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care

(2017) Aline Marnef et al.   JOURNAL OF MOLECULAR BIOLOGY

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

(2017) Fabio Iannelli et al.   Nature Communications

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A meeting at risk: Unrepaired DSBs go for broke

(2017) Aude Guénolé et al.   Nucleus

A meeting at risk: Unrepaired DSBs go for broke

(2017) Aude Guénolé et al.   Nucleus

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(2016) Corina Ohle et al.   CELL

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

(2016) Anirban Chakraborty et al.   Nature Communications

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

(2016) Daniël O. Warmerdam et al.   Cell Reports

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

(2015) Fade Gong et al.   GENES & DEVELOPMENT

A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage

(2015) Marjolein van Sluis et al.   GENES & DEVELOPMENT

Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability

(2015) Jeongkyu Kim et al.   NUCLEIC ACIDS RESEARCH

DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination

(2015) Leizhen Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

(2015) Shane M. Harding et al.   Cell Reports

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks

(2015) Pierre Caron et al.   Cell Reports

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LEDGF (p75) promotes DNA-end resection and homologous recombination

(2012) Mads Daugaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL