A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

(2019) Lea M Korsholm et al.   NUCLEIC ACIDS RESEARCH

The response to DNA damage in heterochromatin domains

(2018) Anna Fortuny et al.   CHROMOSOMA

Dynamic regulation of nucleolar architecture

(2018) Attila Németh et al.   CURRENT OPINION IN CELL BIOLOGY

MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B

(2018) Dafni Eleftheria Pefani et al.   EMBO JOURNAL

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

(2018) Luisa Robbez-Masson et al.   GENOME RESEARCH

Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks

(2018) Eva K. Brinkman et al.   MOLECULAR CELL

CRISPR–Cas9 genome editing in human cells occurs via the Fanconi anemia pathway

(2018) Chris D. Richardson et al.   NATURE GENETICS

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis

(2018) Mikael S. Lindström et al.   ONCOGENE

Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

(2018) Roxanne Oshidari et al.   Nature Communications

Impaired cohesion and homologous recombination during replicative aging in budding yeast

(2018) Sangita Pal et al.   Science Advances

Keep moving and stay in a good shape to find your homologous recombination partner

(2018) Hélène Bordelet et al.   CURRENT GENETICS

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

(2018) Thomas Clouaire et al.   MOLECULAR CELL

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability

(2018) Cornelia Meisenberg et al.   MOLECULAR CELL

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins

(2018) Philippe E. Mangeot et al.   Nature Communications

Joint Reconstruction Strategy for Structured Illumination Microscopy With Unknown Illuminations

(2017) Simon Labouesse et al.   IEEE TRANSACTIONS ON IMAGE PROCESSING

UNC-45a promotes myosin folding and stress fiber assembly

(2017) Jaakko I. Lehtimäki et al.   JOURNAL OF CELL BIOLOGY

Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care

(2017) Aline Marnef et al.   JOURNAL OF MOLECULAR BIOLOGY

Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage

(2017) Josh Lawrimore et al.   MOLECULAR BIOLOGY OF THE CELL

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

(2017) Nian Liu et al.   NATURE

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription

(2017) Chelsea Herdman et al.   PLoS Genetics

A meeting at risk: Unrepaired DSBs go for broke

(2017) Aude Guénolé et al.   Nucleus

A meeting at risk: Unrepaired DSBs go for broke

(2017) Aude Guénolé et al.   Nucleus

Nucleation by rRNA Dictates the Precision of Nucleolus Assembly

(2016) Hanieh Falahati et al.   CURRENT BIOLOGY

Nucleolar organizer regions: genomic ‘dark matter’ requiring illumination

(2016) Brian McStay   GENES & DEVELOPMENT

Evidence for a dual role of actin in regulating chromosome organization and dynamics in yeast

(2016) Maya Spichal et al.   JOURNAL OF CELL SCIENCE

Deep nuclear invaginations are linked to cytoskeletal filaments – integrated bioimaging of epithelial cells in 3D culture

(2016) Danielle M. Jorgens et al.   JOURNAL OF CELL SCIENCE

Nucleolar Reorganization Upon Site-Specific Double-Strand Break Induction

(2016) Michal Franek et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Improving the axial and lateral resolution of three-dimensional fluorescence microscopy using random speckle illuminations

(2016) Awoke Negash et al.   JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION

The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends

(2016) Camille Gelot et al.   MOLECULAR CELL

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation

(2016) Emil Mladenov et al.   SEMINARS IN CANCER BIOLOGY

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

(2016) Daniël O. Warmerdam et al.   Cell Reports

The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: Consequences on genome stability maintenance

(2016) Camille Gelot et al.   Nucleus

Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli

(2016) Ayaka Matsumoto et al.   Nucleus

The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: Consequences on genome stability maintenance

(2016) Camille Gelot et al.   Nucleus

Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli

(2016) Ayaka Matsumoto et al.   Nucleus

53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair

(2015) Francisca Lottersberger et al.   CELL

A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage

(2015) Marjolein van Sluis et al.   GENES & DEVELOPMENT

Transcriptional Elongation Factor ENL Phosphorylated by ATM Recruits Polycomb and Switches Off Transcription for DSB Repair

(2015) Ayako Ui et al.   MOLECULAR CELL

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells

(2015) Meryem Alagoz et al.   NUCLEIC ACIDS RESEARCH

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

(2015) Shane M. Harding et al.   Cell Reports

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks

(2015) Pierre Caron et al.   Cell Reports

DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

(2015) Brittany J Belin et al.   eLife

DNA double strand break repair pathway choice: a chromatin based decision?

(2015) T Clouaire et al.   Nucleus

DNA double strand break repair pathway choice: a chromatin based decision?

(2015) T Clouaire et al.   Nucleus

Inefficient Double-Strand Break Repair in Murine Rod Photoreceptors with Inverted Heterochromatin Organization

(2014) Antonia Frohns et al.   CURRENT BIOLOGY

A role for nuclear envelope–bridging complexes in homology-directed repair

(2014) Rebecca K. Swartz et al.   MOLECULAR BIOLOGY OF THE CELL

SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice

(2014) Chihiro Horigome et al.   MOLECULAR CELL

Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin

(2014) Andreas Kakarougkas et al.   MOLECULAR CELL

The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage

(2014) Dorthe H. Larsen et al.   NATURE CELL BIOLOGY

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The shared genomic architecture of human nucleolar organizer regions

(2013) I. Floutsakou et al.   GENOME RESEARCH

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

(2013) Nicola Crosetto et al.   NATURE METHODS

The Ancient and Evolving Roles of Cohesin in Gene Expression and DNA Repair

(2012) Dale Dorsett et al.   CURRENT BIOLOGY

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

(2012) Pierre Caron et al.   PLoS Genetics

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

(2011) Burkhard Jakob et al.   NUCLEIC ACIDS RESEARCH

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

The nucleolus: structure/function relationship in RNA metabolism

(2010) Danièle Hernandez-Verdun et al.   Wiley Interdisciplinary Reviews-RNA

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT