Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer
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Title
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer
Authors
Keywords
Cyclin-dependent kinase inhibitors, DNA damage response, Cell cycle
Journal
DNA REPAIR
Volume 102, Issue -, Pages 103103
Publisher
Elsevier BV
Online
2021-03-27
DOI
10.1016/j.dnarep.2021.103103
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Note: Only part of the references are listed.- WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation
- (2020) Byung-Kwon Choi et al. CELL CYCLE
- The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27
- (2020) Carmen Rodriguez-Cupello et al. Frontiers in Cell and Developmental Biology
- PIK3R3 inhibits cell senescence through p53/p21 signaling
- (2020) Qianzhi Chen et al. Cell Death & Disease
- Regulation of p27Kip1 and p57Kip2 Functions by Natural Polyphenols
- (2020) Gian Luigi Russo et al. Biomolecules
- YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21Waf1/Cip1
- (2019) Yi Sui et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- p19INK4d: As a cyclin-dependent kinase inhibitor and more
- (2019) Xu Han et al. CURRENT DRUG TARGETS
- p21 in Cancer Research
- (2019) Shamloo et al. Cancers
- The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics
- (2019) Al Bitar et al. Cancers
- P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib
- (2019) Paiyun Li et al. PLoS One
- DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging
- (2019) Matthew M Crane et al. eLife
- Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway
- (2018) Jing Yang et al. BIOMEDICINE & PHARMACOTHERAPY
- Integrating the DNA damage and protein stress responses during cancer development and treatment
- (2018) Vassilis G Gorgoulis et al. JOURNAL OF PATHOLOGY
- PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy
- (2018) Nahal Haddadi et al. Molecular Cancer
- PTEN: Tumor Suppressor and Metabolic Regulator
- (2018) Chien-Yu Chen et al. Frontiers in Endocrinology
- DNA methyltransferases and gastric cancer: insight into targeted therapy
- (2018) Sadegh Fattahi et al. Epigenomics
- ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
- (2017) Andrew N. Blackford et al. MOLECULAR CELL
- Role of CDKN2A/p16 expression in the prognostication of oral squamous cell carcinoma
- (2017) Swati Shree Padhi et al. ORAL ONCOLOGY
- STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo
- (2017) Hisham Bazzi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex
- (2017) Yonggang Zheng et al. Cell Reports
- Dual Role of p21 in the Progression of Cancer and Its Treatment
- (2016) Amna Parveen et al. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
- Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
- (2016) Ansar Karimian et al. DNA REPAIR
- Wip1 phosphatase: between p53 and MAPK kinases pathways
- (2016) Anastasia R. Goloudina et al. Oncotarget
- Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
- (2016) Mohammad A. Jafri et al. Genome Medicine
- p27Kip1 Is Required to Mediate a G1 Cell Cycle Arrest Downstream of ATM following Genotoxic Stress
- (2016) Erica K. Cassimere et al. PLoS One
- p21 Exploits Residue Tyr151 as a Tether for High-Affinity PCNA Binding
- (2015) Alice J. Kroker et al. BIOCHEMISTRY
- ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels
- (2015) S Rondeau et al. BRITISH JOURNAL OF CANCER
- Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis
- (2015) Daniel J. Anderson et al. CANCER CELL
- DNA Damage in Cancer Therapeutics: A Boon or a Curse?
- (2015) Anchit Khanna CANCER RESEARCH
- ATM and ATR signaling at a glance
- (2015) P. Awasthi et al. JOURNAL OF CELL SCIENCE
- The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle
- (2015) I. A. Shaltiel et al. JOURNAL OF CELL SCIENCE
- The Activity and Stability of the Intrinsically Disordered Cip/Kip Protein Family AreRegulated by Non-Receptor TyrosineKinases
- (2015) Yongqi Huang et al. JOURNAL OF MOLECULAR BIOLOGY
- Cellular Response upon Stress: p57 Contribution to the Final Outcome
- (2015) Marianna Nicoletta Rossi et al. MEDIATORS OF INFLAMMATION
- The history and future of targeting cyclin-dependent kinases in cancer therapy
- (2015) Uzma Asghar et al. NATURE REVIEWS DRUG DISCOVERY
- CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation
- (2015) Noelle E. Huskey et al. Stem Cell Reports
- Dux4 induces cell cycle arrest at G1 phase through upregulation of p21 expression
- (2014) Hongliang Xu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mutant TP53 Posttranslational Modifications: Challenges and Opportunities
- (2014) Thuy-Ai Nguyen et al. HUMAN MUTATION
- p19Ink4d Is a Tumor Suppressor and Controls Pituitary Anterior Lobe Cell Proliferation
- (2014) F. Bai et al. MOLECULAR AND CELLULAR BIOLOGY
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- STRIPAK components determine mode of cancer cell migration and metastasis
- (2014) Chris D. Madsen et al. NATURE CELL BIOLOGY
- p57Kip2 is an unrecognized DNA damage response effector molecule that functions in tumor suppression and chemoresistance
- (2014) H Jia et al. ONCOGENE
- Mitogen-Activated Protein Kinase (MAPK) Pathway Regulates Branching by Remodeling Epithelial Cell Adhesion
- (2014) Anneliis Ihermann-Hella et al. PLoS Genetics
- Cyclin-dependent kinases
- (2014) Marcos Malumbres GENOME BIOLOGY
- CDK inhibitor p57Kip2is downregulated by Akt during HER2-mediated tumorigenicity
- (2013) Ruiying Zhao et al. CELL CYCLE
- Derailed Estrogen Signaling and Breast Cancer: An Authentic Couple
- (2013) Bramanandam Manavathi et al. ENDOCRINE REVIEWS
- PI3K Stimulates DNA Synthesis and Cell-Cycle Progression via Its p55PIK Regulatory Subunit Interaction with PCNA
- (2013) G. Wang et al. MOLECULAR CANCER THERAPEUTICS
- Non-Steroidal Anti-inflammatory Drugs Decrease E2F1 Expression and Inhibit Cell Growth in Ovarian Cancer Cells
- (2013) Blanca L. Valle et al. PLoS One
- Chromatin Relaxation-Mediated Induction of p19INK4d Increases the Ability of Cells to Repair Damaged DNA
- (2013) María F. Ogara et al. PLoS One
- DNA Damage Sensing by the ATM and ATR Kinases
- (2013) A. Marechal et al. Cold Spring Harbor Perspectives in Biology
- Cyclin dependent kinases in cancer
- (2012) Miriam Canavese et al. CANCER BIOLOGY & THERAPY
- The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress
- (2012) Manel Joaquin et al. EMBO JOURNAL
- E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation
- (2012) Abel L. Carcagno et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production
- (2012) Da-yong Zhang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
- (2012) Stéphane Larochelle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- CDK2 and PKA Mediated-Sequential Phosphorylation Is Critical for p19INK4d Function in the DNA Damage Response
- (2012) Mariela C. Marazita et al. PLoS One
- Therapeutic targeting of cancer cell cycle using proteasome inhibitors
- (2012) Namrata Rastogi et al. Cell Division
- Regulatory Mechanisms of Tumor Suppressor P16INK4Aand Their Relevance to Cancer
- (2011) Junan Li et al. BIOCHEMISTRY
- The hallmarks of CDKN1C (p57, KIP2) in cancer
- (2011) Edel Kavanagh et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- p53 methylation—the Arg-ument is clear
- (2011) Stephen T. Durant et al. CELL CYCLE
- p21Cip1/WAF1mediates cyclin B1 degradation in response to DNA damage
- (2011) Laura D. Gillis et al. CELL CYCLE
- Functional similarities and uniqueness of p27 and p57: Insight from a knock-in mouse model
- (2011) Etsuo Susaki et al. CELL CYCLE
- Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer
- (2011) Gottfried E. Konecny et al. CLINICAL CANCER RESEARCH
- Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation
- (2011) Y.-H. Lee et al. GENES & DEVELOPMENT
- Incomplete Folding upon Binding Mediates Cdk4/Cyclin D Complex Activation by Tyrosine Phosphorylation of Inhibitor p27 Protein
- (2011) Li Ou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ADAM17 regulates prostate cancer cell proliferation through mediating cell cycle progression by EGFR/PI3K/AKT pathway
- (2011) Ping Lin et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Human NDR Kinases Control G1/S Cell Cycle Transition by Directly Regulating p21 Stability
- (2011) H. Cornils et al. MOLECULAR AND CELLULAR BIOLOGY
- p57Kip2 and Cancer: Time for a Critical Appraisal
- (2011) A. Borriello et al. MOLECULAR CANCER RESEARCH
- Wnt/β-Catenin Signaling Induces the Aging of Mesenchymal Stem Cells through the DNA Damage Response and the p53/p21 Pathway
- (2011) Da-yong Zhang et al. PLoS One
- Switching cyclin D-Cdk4 kinase activity on and off
- (2010) Stacy Blain CELL CYCLE
- DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions
- (2010) Olivier Sordet et al. CELL CYCLE
- The roles of p27Kip1 and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint
- (2010) Michalis Liontos et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas
- (2010) W L See et al. ONCOGENE
- Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure
- (2010) J L Dean et al. ONCOGENE
- Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells
- (2009) Jun Chen et al. ASIAN JOURNAL OF ANDROLOGY
- p27Kip1 Stabilization Is Essential for the Maintenance of Cell Cycle Arrest in Response to DNA Damage
- (2009) M. Cuadrado et al. CANCER RESEARCH
- Cyclin A Is Redundant in Fibroblasts but Essential in Hematopoietic and Embryonic Stem Cells
- (2009) Ilona Kalaszczynska et al. CELL
- Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins
- (2009) Anna W. Maniccia et al. JOURNAL OF CELLULAR PHYSIOLOGY
- TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II
- (2009) K. Glover-Cutter et al. MOLECULAR AND CELLULAR BIOLOGY
- PRMT5 is required for cell-cycle progression and p53 tumor suppressor function
- (2009) A. Scoumanne et al. NUCLEIC ACIDS RESEARCH
- MicroRNA 92b Controls the G1/S Checkpoint Gene p57 in Human Embryonic Stem Cells
- (2009) Srikumar Sengupta et al. STEM CELLS
- CDK Inhibitors: Cell Cycle Regulators and Beyond
- (2008) Arnaud Besson et al. DEVELOPMENTAL CELL
- P18is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development
- (2008) Wendy van Veelen et al. INTERNATIONAL JOURNAL OF CANCER
- Dual Regulation of Cdc25A by Chk1 and p53-ATF3 in DNA Replication Checkpoint Control
- (2008) Anastasia R. Demidova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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