p57Kip2 is an unrecognized DNA damage response effector molecule that functions in tumor suppression and chemoresistance

CDK inhibitor p57Kip2is downregulated by Akt during HER2-mediated tumorigenicity

(2013) Ruiying Zhao et al.   CELL CYCLE

p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis

(2013) Shohei Furutachi et al.   EMBO JOURNAL

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

(2013) Georgia Velimezi et al.   NATURE CELL BIOLOGY

Identification of 5-Iodotubercidin as a Genotoxic Drug with Anti-Cancer Potential

(2013) Xin Zhang et al.   PLoS One

CDKN1C/P57 Is Regulated by the Notch Target Gene Hes1 and Induces Senescence in Human Hepatocellular Carcinoma

(2012) Catia Giovannini et al.   AMERICAN JOURNAL OF PATHOLOGY

The roles of ATF2 (activating transcription factor 2) in tumorigenesis

(2012) Malgorzata Gozdecka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

p57KIP2 regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex

(2012) G. Mairet-Coello et al.   DEVELOPMENT

The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress

(2012) Manel Joaquin et al.   EMBO JOURNAL

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation

(2012) Aurelia Barascu et al.   EMBO JOURNAL

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

(2012) Katja Höpker et al.   EMBO JOURNAL

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair

(2012) Qi-En Wang et al.   NUCLEIC ACIDS RESEARCH

p57KIP2 control of actin cytoskeleton dynamics is responsible for its mitochondrial pro-apoptotic effect

(2012) E Kavanagh et al.   Cell Death & Disease

A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response

(2012) Jenny Fung Ling Chau et al.   Nature Communications

Functional similarities and uniqueness of p27 and p57: Insight from a knock-in mouse model

(2011) Etsuo Susaki et al.   CELL CYCLE

p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells

(2011) Akinobu Matsumoto et al.   Cell Stem Cell

A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF- B and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage

(2011) Y. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

p57Kip2 and Cancer: Time for a Critical Appraisal

(2011) A. Borriello et al.   MOLECULAR CANCER RESEARCH

Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors

(2011) Natalia G. Starostina et al.   TRENDS IN CELL BIOLOGY

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

(2010) Keng Po Lai et al.   EMBO JOURNAL

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

(2010) H. Christian Reinhardt et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response

(2010) Ornella Cazzalini et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

(2010) I. G. Cannell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p21WAF1/CIP1and cancer: A shifting paradigm?

(2009) Andrei L. Gartel   BIOFACTORS

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

p57KIP2: "Kip"ing the Cell under Control

(2009) I. S. Pateras et al.   MOLECULAR CANCER RESEARCH

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells

(2009) Xiaojing Yang et al.   PLoS One

Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model

(2009) E. Susaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origins and Evolution of the p53 Family of Genes

(2009) V. A. Belyi et al.   Cold Spring Harbor Perspectives in Biology

CDK Inhibitors: Cell Cycle Regulators and Beyond

(2008) Arnaud Besson et al.   DEVELOPMENTAL CELL

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

(2008) Z. Ullah et al.   GENES & DEVELOPMENT

Regulation of TIP60 by ATF2 Modulates ATM Activation

(2008) Anindita Bhoumik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY