The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes
Authors
Keywords
-
Journal
DIABETOLOGIA
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-09-17
DOI
10.1007/s00125-021-05553-w
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes
- (2021) Sharona Tornovsky-Babeay et al. DIABETOLOGIA
- Clinical and Enzymatic Phenotypes in Congenital Hyperinsulinemic Hypoglycemia due to Glucokinase‐activating Mutations: a report of two cases and a brief overview of literature
- (2019) Fan Ping et al. Journal of Diabetes Investigation
- 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms
- (2019) Sara Langer et al. BIOCHEMICAL PHARMACOLOGY
- α-cell glucokinase suppresses glucose-regulated glucagon secretion
- (2018) Davide Basco et al. Nature Communications
- Characterization of two MODY2 mutations with different susceptibility to activation
- (2015) Sara Langer et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage
- (2015) Arianna Maiorana et al. Orphanet Journal of Rare Diseases
- The ubiquitin–proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells
- (2013) Anke Hofmeister-Brix et al. BIOCHEMICAL JOURNAL
- Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein
- (2013) Tobias Beck et al. BIOCHEMISTRY
- Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes
- (2013) D J Baker et al. BRITISH JOURNAL OF PHARMACOLOGY
- Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells
- (2013) Sharona Tornovsky-Babeay et al. Cell Metabolism
- Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260
- (2012) Simone Baltrusch et al. BIOCHEMICAL PHARMACOLOGY
- Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation
- (2012) Sara Langer et al. FEBS LETTERS
- Insights into Mechanism of Glucokinase Activation
- (2012) Shenping Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The active conformation of human glucokinase is not altered by allosteric activators
- (2011) Pierre Petit et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Mutational analysis of allosteric activation and inhibition of glucokinase
- (2011) Bogumil Zelent et al. BIOCHEMICAL JOURNAL
- Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk
- (2011) M. G. Rees et al. DIABETOLOGIA
- Discovery of a Novel Site Regulating Glucokinase Activity following Characterization of a New Mutation Causing Hyperinsulinemic Hypoglycemia in Humans
- (2011) Nicola L. Beer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation
- (2010) Sameer Kassem et al. NEW ENGLAND JOURNAL OF MEDICINE
- 23-Residue C-Terminal α-Helix Governs Kinetic Cooperativity in Monomeric Human Glucokinase
- (2009) Mioara Larion et al. BIOCHEMISTRY
- Activating Mutations in the Human Glucokinase Gene Revealed by Genetic Selection
- (2009) Priya Pal et al. BIOCHEMISTRY
- Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations
- (2009) S. Sayed et al. DIABETES
- The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
- (2009) Nicola L. Beer et al. HUMAN MOLECULAR GENETICS
- The genetic basis of congenital hyperinsulinism
- (2009) C James et al. JOURNAL OF MEDICAL GENETICS
- Glucokinase (GCK) and other susceptibility genes for β-cell dysfunction: the candidate approach
- (2008) Anna L. Gloyn et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Prevalence of GCK mutations in individuals screened for fasting hyperglycaemia
- (2008) A. L. Gloyn et al. DIABETOLOGIA
- Diagnostic Difficulties in Glucokinase Hyperinsulinism
- (2008) T. Meissner et al. HORMONE AND METABOLIC RESEARCH
- The glucostatic theory of appetite control and the risk of obesity and diabetes
- (2008) J-P Chaput et al. INTERNATIONAL JOURNAL OF OBESITY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started