Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes

Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes

(2020) Gordon C Weir et al.   Lancet Diabetes & Endocrinology

Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability

(2020) Aref G. Ebrahimi et al.   Molecular Metabolism

β-cell secretory dysfunction: a key cause of type 2 diabetes – Authors' reply

(2020) Gordon C Weir et al.   Lancet Diabetes & Endocrinology

β-cell secretory dysfunction: a key cause of type 2 diabetes

(2020) Rury R Holman et al.   Lancet Diabetes & Endocrinology

Single cell transcriptomics of human islet ontogeny defines the molecular basis of β cell dedifferentiation in T2D

(2020) Dana Avrahami et al.   Molecular Metabolism

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

(2019) Peter J. Thompson et al.   Cell Metabolism

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

(2017) Giovanni Lenguito et al.   LAB ON A CHIP

Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancers

(2017) Daniel Neiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the role of neuronal glucokinase

(2016) Ivan De Backer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Mathematical Model of the Pathogenesis, Prevention, and Reversal of Type 2 Diabetes

(2016) Joon Ha et al.   ENDOCRINOLOGY

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Dose-ranging study with the glucokinase activator AZD1656 in patients with type 2 diabetes mellitus on metformin

(2013) J. P. H. Wilding et al.   DIABETES OBESITY & METABOLISM

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

(2011) Shay Porat et al.   Cell Metabolism

Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes

(2011) G. E. Meininger et al.   DIABETES CARE

Endoplasmic reticulum stress and pancreatic β-cell death

(2011) Sonya G. Fonseca et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Brain expression of Cre recombinase driven by pancreas-specific promoters

(2010) Junghun Song et al.   GENESIS

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

(2010) Sameer Kassem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations

(2009) S. Sayed et al.   DIABETES

Advanced Glycation End Products Inhibit Glucose-Stimulated Insulin Secretion through Nitric Oxide-Dependent Inhibition of CytochromecOxidase and Adenosine Triphosphate Synthesis

(2009) Zhengshan Zhao et al.   ENDOCRINOLOGY

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Long-Term Follow-Up of Oral Glucose Tolerance Test-Derived Glucose Tolerance and Insulin Secretion and Insulin Sensitivity Indexes in Subjects With Glucokinase Mutations (MODY2)

(2008) D. Martin et al.   DIABETES CARE

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION