Discovery of a Novel Site Regulating Glucokinase Activity following Characterization of a New Mutation Causing Hyperinsulinemic Hypoglycemia in Humans

Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study

(2010) Riccardo C. Bonadonna et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

(2010) Sameer Kassem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activating Mutations in the Human Glucokinase Gene Revealed by Genetic Selection

(2009) Priya Pal et al.   BIOCHEMISTRY

Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations

(2009) S. Sayed et al.   DIABETES

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

(2009) Kara K. Osbak et al.   HUMAN MUTATION

Opposite Clinical Phenotypes of Glucokinase Disease: Description of a Novel Activating Mutation and Contiguous Inactivating Mutations in Human Glucokinase (GCK) Gene

(2009) Fabrizio Barbetti et al.   MOLECULAR ENDOCRINOLOGY

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation.

(2008) Henrik B T Christesen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Glucokinase activators in diabetes management

(2008) Matthew Coghlan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Diagnostic Difficulties in Glucokinase Hyperinsulinism

(2008) T. Meissner et al.   HORMONE AND METABOLIC RESEARCH

Permanent Neonatal Diabetes Mellitus Caused by a Novel Homozygous (T168A) Glucokinase (GCK) Mutation: Initial Response to Oral Sulphonylurea Therapy

(2008) Doga Turkkahraman et al.   JOURNAL OF PEDIATRICS

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

(2008) Nika N Danial et al.   NATURE MEDICINE

Permanent neonatal diabetes caused by a homozygous nonsense mutation in the glucokinase gene

(2008) O Rubio-Cabezas et al.   PEDIATRIC DIABETES