The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes

Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes

(2021) Sharona Tornovsky-Babeay et al.   DIABETOLOGIA

Clinical and Enzymatic Phenotypes in Congenital Hyperinsulinemic Hypoglycemia due to Glucokinase‐activating Mutations: a report of two cases and a brief overview of literature

(2019) Fan Ping et al.   Journal of Diabetes Investigation

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms

(2019) Sara Langer et al.   BIOCHEMICAL PHARMACOLOGY

α-cell glucokinase suppresses glucose-regulated glucagon secretion

(2018) Davide Basco et al.   Nature Communications

Characterization of two MODY2 mutations with different susceptibility to activation

(2015) Sara Langer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage

(2015) Arianna Maiorana et al.   Orphanet Journal of Rare Diseases

The ubiquitin–proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells

(2013) Anke Hofmeister-Brix et al.   BIOCHEMICAL JOURNAL

Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein

(2013) Tobias Beck et al.   BIOCHEMISTRY

Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes

(2013) D J Baker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260

(2012) Simone Baltrusch et al.   BIOCHEMICAL PHARMACOLOGY

Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation

(2012) Sara Langer et al.   FEBS LETTERS

Insights into Mechanism of Glucokinase Activation

(2012) Shenping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The active conformation of human glucokinase is not altered by allosteric activators

(2011) Pierre Petit et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mutational analysis of allosteric activation and inhibition of glucokinase

(2011) Bogumil Zelent et al.   BIOCHEMICAL JOURNAL

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk

(2011) M. G. Rees et al.   DIABETOLOGIA

Discovery of a Novel Site Regulating Glucokinase Activity following Characterization of a New Mutation Causing Hyperinsulinemic Hypoglycemia in Humans

(2011) Nicola L. Beer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

(2010) Sameer Kassem et al.   NEW ENGLAND JOURNAL OF MEDICINE

23-Residue C-Terminal α-Helix Governs Kinetic Cooperativity in Monomeric Human Glucokinase

(2009) Mioara Larion et al.   BIOCHEMISTRY

Activating Mutations in the Human Glucokinase Gene Revealed by Genetic Selection

(2009) Priya Pal et al.   BIOCHEMISTRY

Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations

(2009) S. Sayed et al.   DIABETES

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

The genetic basis of congenital hyperinsulinism

(2009) C James et al.   JOURNAL OF MEDICAL GENETICS

Glucokinase (GCK) and other susceptibility genes for β-cell dysfunction: the candidate approach

(2008) Anna L. Gloyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Prevalence of GCK mutations in individuals screened for fasting hyperglycaemia

(2008) A. L. Gloyn et al.   DIABETOLOGIA

Diagnostic Difficulties in Glucokinase Hyperinsulinism

(2008) T. Meissner et al.   HORMONE AND METABOLIC RESEARCH

The glucostatic theory of appetite control and the risk of obesity and diabetes

(2008) J-P Chaput et al.   INTERNATIONAL JOURNAL OF OBESITY