The ubiquitin–proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells

GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation

(2012) Maria Negahdar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea

(2012) B. Zelent et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin–proteasome system in pancreatic beta cell dysfunction

(2012) Marco Bugliani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Association with Nitric Oxide Synthase on Insulin Secretory Granules Regulates Glucokinase Protein Levels

(2012) Michele L. Markwardt et al.   MOLECULAR ENDOCRINOLOGY

A Critical Re-Evaluation of CD24-Positivity of Human Embryonic Stem Cells Differentiated into Pancreatic Progenitors

(2012) Ortwin Naujok et al.   Stem Cell Reviews and Reports

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic  -Cells

(2011) K. S. Cullen et al.   DIABETES

Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels

(2011) H. Schmitt et al.   DIABETOLOGIA

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: A possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition

(2010) Marianne S. Poruchynsky et al.   CELL CYCLE

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

 -Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency

(2010) S. Costes et al.   DIABETES

Endogenous Activation of Glucokinase by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Is Glucose Dependent

(2010) Sara Langer et al.   MOLECULAR ENDOCRINOLOGY

Binding Kinetics of Glucose and Allosteric Activators to Human Glucokinase Reveal Multiple Conformational States

(2009) Mathias Antoine et al.   BIOCHEMISTRY

Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic β-cells

(2008) Taila Hartley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Global Protein Stability Profiling in Mammalian Cells

(2008) H.-C. S. Yen et al.   SCIENCE