Adenovirus vector-attributed hepatotoxicity blocks clinical application in gene therapy

The Inflammatory and Fibrotic Patterns of Hepatic Stellate Cells Following Coagulation Factors (VII or X)-Shielded Adenovirus Infection

(2021) Alireza Shiri et al.   CURRENT MICROBIOLOGY

Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46

(2021) B. David Persson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of γδT cells in liver diseases and its relationship with intestinal microbiota

(2020) Qi-Hui Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

(2020) Noe B. Mercado et al.   NATURE

Detection of Adenovirus Hepatitis and Acute Liver Failure in Allogeneic Hematopoietic Stem Cell Transplant Patients

(2020) Yoshiyuki Onda et al.   Transplant Infectious Disease

Systemic cancer therapy with engineered adenovirus that evades innate immunity

(2020) Svetlana Atasheva et al.   Science Translational Medicine

Human adenovirus binding to host cell receptors: a structural view

(2019) Aleksandra Cecylia Stasiak et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Oncorine, the World First Oncolytic Virus Medicine and its Update in China

(2018) Min Liang   CURRENT CANCER DRUG TARGETS

Polysialic acid is a cellular receptor for human adenovirus 52

(2018) Annasara Lenman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kupffer cell-derived TNF-α promotes hepatocytes to produce CXCL1 and mobilize neutrophils in response to necrotic cells

(2018) Li Su et al.   Cell Death & Disease

Natural Killer Cells: Development, Maturation, and Clinical Utilization

(2018) Alex M. Abel et al.   Frontiers in Immunology

Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

(2017) Jack van Horssen et al.   NEUROSCIENCE LETTERS

Oncolytic Viruses—Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer

(2017) Anwen Howells et al.   Frontiers in Oncology

Adenovirus sensing by the immune system

(2016) Svetlana Atasheva et al.   Current Opinion in Virology

Beyond RGD: virus interactions with integrins

(2015) Hosni A. M. Hussein et al.   ARCHIVES OF VIROLOGY

Concurrent Acute Necrotizing Adenovirus Hepatitis and Enterocolitis in an Adult Patient After Double Cord Blood Stem Cell Transplant for Refractory Crohn’s Disease

(2015) Amy A. Lo et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Manipulating Adenovirus Hexon Hypervariable Loops Dictates Immune Neutralisation and Coagulation Factor X-dependent Cell Interaction In Vitro and In Vivo

(2015) Jiangtao Ma et al.   PLoS Pathogens

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

(2014) T. Lion   CLINICAL MICROBIOLOGY REVIEWS

Biomarkers of liver cell death

(2014) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

Adenovirus Vector-Induced Innate Inflammatory Mediators, MAPK Signaling, As Well As Adaptive Immune Responses Are Dependent upon Both TLR2 and TLR9 In Vivo

(2014) D. M. Appledorn et al.   JOURNAL OF IMMUNOLOGY

Molecular Characterization of a Lizard Adenovirus Reveals the First Atadenovirus with Two Fiber Genes and the First Adenovirus with Either One Short or Three Long Fibers per Penton

(2014) J. J. Penzes et al.   JOURNAL OF VIROLOGY

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Transgene Expression up to 7 Years in Nonhuman Primates Following Hepatic Transduction with Helper-Dependent Adenoviral Vectors

(2013) Nicola Brunetti-Pierri et al.   HUMAN GENE THERAPY

Fulminant hepatitis due to human adenovirus

(2013) B. A. Ronan et al.   INFECTION

Coagulation Factor Binding Orientation and Dimerization May Influence Infectivity of Adenovirus-Coagulation Factor Complexes

(2013) E. E. Irons et al.   JOURNAL OF VIROLOGY

Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement

(2013) Zhili Xu et al.   NATURE MEDICINE

Co-transduction of ribosomal protein L23 enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in human gastric cancer

(2013) YA-FEI ZHANG et al.   ONCOLOGY REPORTS

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

(2013) A. Horowitz et al.   Science Translational Medicine

Human adenovirus type 41 possesses different amount of short and long fibers in the virion

(2012) Jing-Dong Song et al.   VIROLOGY

Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus)

(2011) R Alba et al.   GENE THERAPY

Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells

(2011) Gleb Turchinovich et al.   IMMUNITY

Generation of a Kupffer Cell-evading Adenovirus for Systemic and Liver-directed Gene Transfer

(2011) Reeti Khare et al.   MOLECULAR THERAPY

Adenovirus

(2011) Joseph Lynch et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

(2010) R. Alba et al.   BLOOD

A phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: Armed oncolytic adenovirus for the treatment of head and neck cancers

(2010) Jianhua Chang et al.   CANCER BIOLOGY & THERAPY

Activating and inhibitory receptors of natural killer cells

(2010) Hollie J Pegram et al.   IMMUNOLOGY AND CELL BIOLOGY

Substitution of Adenovirus Serotype 3 Hexon onto a Serotype 5 Oncolytic Adenovirus Reduces Factor X Binding, Decreases Liver Tropism, and Improves Antitumor Efficacy

(2010) J. J. Short et al.   MOLECULAR CANCER THERAPEUTICS

Modifications of Adenovirus Hexon Allow for Either Hepatocyte Detargeting or Targeting With Potential Evasion From Kupffer Cells

(2010) Jan-Michael Prill et al.   MOLECULAR THERAPY

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

(2010) Hongjie Wang et al.   NATURE MEDICINE

The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis

(2010) Emma C Nilsson et al.   NATURE MEDICINE

Adenoviral Producer Cells

(2010) Imre Kovesdi et al.   Viruses-Basel

An Update on Canine Adenovirus Type 2 and Its Vectors

(2010) Thierry Bru et al.   Viruses-Basel

Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X

(2010) Angela C. Bradshaw et al.   PLoS Pathogens

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

(2009) R. Alba et al.   BLOOD

Scavenger Receptor A: A New Route for Adenovirus 5

(2009) Hidde J. Haisma et al.   MOLECULAR PHARMACEUTICS

CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

(2009) Julie C Ribot et al.   NATURE IMMUNOLOGY

From the first to the third generation adenoviral vector: What parameters are governing the production yield?

(2008) E. Dormond et al.   BIOTECHNOLOGY ADVANCES

Neutrophil mobilization and clearance in the bone marrow

(2008) Rebecca C. Furze et al.   IMMUNOLOGY

  T Cells Initiate Acute Inflammation and Injury in Adenovirus-Infected Liver via Cytokine-Chemokine Cross Talk

(2008) M. N. Ajuebor et al.   JOURNAL OF VIROLOGY

Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement

(2008) Z. Xu et al.   JOURNAL OF VIROLOGY

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

(2008) O. Kalyuzhniy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability of the seven hexon hypervariable region sequences of adenovirus types 1–6 isolated in Yamagata, Japan between 1988 and 2007

(2008) Katsumi Mizuta et al.   VIRUS RESEARCH

Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia

(2007) Isabelle Steiner et al.   PEDIATRIC BLOOD & CANCER